Exercise-Induced Change in Plasma IL-12p70 Is Linked to Migraine Prevention and Anxiolytic Effects in Treatment-Na ïve Women: A Randomized Controlled Trial
Conclusion: The clinical and psychological therapeutic effects of aerobic exercise in treatment-na ïve women with migraine may involve the downregulation of IL-12p70.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - March 29, 2018 Category: Allergy & Immunology Source Type: research
Vitamin B < sub > 12 < /sub > in Association with Antipsychotic Drugs Can Modulate the Expression of Pro-/Anti-Inflammatory Cytokines in Alzheimer Disease Patients
Discussion: Proinflammatory cytokines play important roles in the pathogenesis of psychosis in AD patients. Antipsychotic drugs plus vitamin B12 can reduce and induce the expression of proinflammatory and anti-inflammatory cytokines to improve psychotic symptoms in AD patients.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - March 20, 2018 Category: Allergy & Immunology Source Type: research
Immune Cell Neurotrophin Production Is Associated with Subcortical Brain Atrophy in Neuropsychiatric Systemic Lupus Erythematosus Patients
Conclusions: In NPSLE, immune cell BDNF and NGF levels are linked with subcortical atrophy. Higher BDNF levels are associated with higher midsagittal atrophy, which may reflect compensatory mechanisms, upregulating BDNF when neuroprotection is needed. These data require further confirmation.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - March 14, 2018 Category: Allergy & Immunology Source Type: research
Differential Response of Dopamine Mediated by β-Adrenergic Receptors in Human Keratinocytes and Macrophages: Potential Implication in Wound Healing
Conclusion: We suggest that the effect of dopamine via β-ARs depends on the physiological condition and the cell type involved, thus contributing to either improve or interfere with the healing process.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - March 8, 2018 Category: Allergy & Immunology Source Type: research
Cytokine Production by Mononuclear Cells from Patients with Familial Infantile Bilateral Striatal Necrosis
Prompted by findings suggesting immune instability in infantile bilateral striatal necrosis (IBSN), we evaluated levels of proinflammatory (tumor necrosis factor α, interleukin [IL]-1β, IL-6, interferon [IFN]γ) and anti-inflammatory (IL-10 and IL-1ra) cytokines produced by peripheral blood mononuclear cells (PBMC) from 6 children with IBSN and 11 age-matched controls. Compared to controls, non-stimulated PBMC from the IBSN group produced a significantly l ower level of IL-1ra (by 38%;p #x3c; 0.001) and significantly lower levels of TNF α, IL-1β, and IFNγ (by 36% [p #x3c; 0.001], 25% [p = 0.06], and 32% [p #x3c; 0.02]...
Source: Neuroimmunomodulation - March 6, 2018 Category: Allergy & Immunology Source Type: research
TNFAIP3 mRNA Level Is Associated with Psychological Anxiety in Major Depressive Disorder
Conclusion: These findings suggest a significant association between anxiety and TNFAIP3 mRNA levels in patients with MDD.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - February 27, 2018 Category: Allergy & Immunology Source Type: research
Increased Proportion of Tc17 and Th17 Cells and Their Significant Reduction after Thymectomy May Be Related to Disease Progression in Myasthenia Gravis
In this study, the frequency of Th17 and Tc17 cells was studied in 12 MG patients (pre-TE and 6 months post-TE) and in 12 healthy controls (HC).Results: The frequency of Tc17 cells in the pre-TE patients was significantly higher than in the HC (p (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - February 7, 2018 Category: Allergy & Immunology Source Type: research
Lipid Metabolism in Patients with Anti-N-Methyl- < smlcap > D < /smlcap > -Aspartate Receptor Encephalitis
Conclusion: Serum HDL-C and apoA-I levels are reduced in the initial phase of anti-NMDAR encephalitis and recover after treatment. Further studies about the role of serum lipid in anti-NMDAR encephalitis are needed.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - January 31, 2018 Category: Allergy & Immunology Source Type: research
Differential Neuroprotective Effects of Interleukin-1 Receptor Antagonist on Spinal Cord Neurons after Excitotoxic Injury
Secondary damage following spinal cord injury (SCI) induces neuronal damage through inflammatory and excitotoxic pathways. We hypothesized that the interleukin-1 receptor antagonist (IL1RA) protects neuronal populations and suppresses apoptosis and gliosis after injury. Spinal cord slice cultures (SCSCs) were subjected to excitotoxic injury with N-methyl-D-aspartate (NMDA) and treated with IL1RA. Immunohistochemistry for neuronal nuclei (NeuN), MacII, glial fibrillary acidic protein, and TdT-mediated dUTP nick end labelling stains were used to evaluate neuronal survival, glial activation, and apoptosis. Treatment with IL1R...
Source: Neuroimmunomodulation - January 25, 2018 Category: Allergy & Immunology Source Type: research
Early Life Stress Activates Glial Cells in the Hippocampus but Attenuates Cytokine Secretion in Response to an Immune Challenge in Rat Pups
Conclusion: Although MS and LPS activate neuroimmune cells, stress attenuates the hippocampal and peripheral cytokine response to LPS through an as-yet unidentified adaptive mechanism. These results provide information regarding the neurobiology of stress and inflammation.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - January 12, 2018 Category: Allergy & Immunology Source Type: research
Suprachiasmatic Nucleus and Subordinate Brain Oscillators: Clock Gene Desynchronization by Neuroinflammation
Conclusions: These results indicate that a neuroinflammatory condition leads to desynchronization of primary and subordinate brain oscillators, supporting the existence of the integration between the immune and the circadian system.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - January 4, 2018 Category: Allergy & Immunology Source Type: research
A Novel Animal Model Simulating the Beginning of Combat Exposure
This study utilized a novel animal model simulating the beginning of combat exposure that aided specification of a set of biomarkers.Methods: Psychological stress was induced by both inescapable electric foot shock and noise stimuli. Physical fatigue was induced by sleep deprivation and forced exercise in a rotating cage. A new device reflecting simultaneous psychological stress and physical fatigue was constructed. The protocol simulating combat exposure was set as 3 rounds of 24-h exposure in a 2-week period, which was specified as intermittent unpredictable stress (IUS).Results: Mice exposed to IUS(IUS mice) had signifi...
Source: Neuroimmunomodulation - November 21, 2017 Category: Allergy & Immunology Source Type: research
Immunoregulatory Role of Cannabinoids during Infectious Disease
Although the endocannabinoid system (ECS) is involved in the regulation of several physiological processes, including sleep and the immune response, its role during infections has not been fully studied. It is well known that the use of this drug increases susceptibility to infections because of the impact on the modulation of the immune system. Concerning the medicinal or recreational use of marijuana, its influence on the course of an infection, whether this has been caused by bacteria, viruses, parasites, and to a lesser degree, fungi, has been reported. Furthermore, there is evidence suggesting the involvement of the E...
Source: Neuroimmunomodulation - November 17, 2017 Category: Allergy & Immunology Source Type: research
Depressed Immune Responses and Accelerated Splenic Apoptosis due to Experience of Food Deprivation and Inequality but not Unstable Social Status in Balb/c Mice
Objective(s): We aimed to show that the immune system is sensitive to the detrimental effects of inequality and social injustice, and splenic vulnerability to apoptosis may also increase.Methods: In order of better determination of immune responses to chronic social stress, we implemented food deprivation, food intake inequality, and unstable social status (a change of cage-mate every 3 days) for a period of 14 days in 60 male Balb/c mice. At the end of this stress period, nitric oxide (NO) production by peritoneal adherent cells and the serum concentration of corticosterone were measured. Moreover, the viability of perito...
Source: Neuroimmunomodulation - November 16, 2017 Category: Allergy & Immunology Source Type: research
Rosmarinic Acid Attenuates the Activation of Murine Microglial N9 Cells through the Downregulation of Inflammatory Cytokines and Cleaved Caspase-3
Conclusions: The results suggested a protective effect of RA through downregulation of inflammatory cytokines and cleaved caspase-3.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - November 6, 2017 Category: Allergy & Immunology Source Type: research
