A Novel Animal Model Simulating the Beginning of Combat Exposure

This study utilized a novel animal model simulating the beginning of combat exposure that aided specification of a set of biomarkers.Methods: Psychological stress was induced by both inescapable electric foot shock and noise stimuli. Physical fatigue was induced by sleep deprivation and forced exercise in a rotating cage. A new device reflecting simultaneous psychological stress and physical fatigue was constructed. The protocol simulating combat exposure was set as 3 rounds of 24-h exposure in a 2-week period, which was specified as intermittent unpredictable stress (IUS).Results: Mice exposed to IUS(IUS mice) had significantly higher serum corticosterone levels (p
Source: Neuroimmunomodulation - Category: Allergy & Immunology Source Type: research