Pharmacological Activity of Pyrazole Derivatives as an Anticonvulsant for Benefit against Epilepsy
Conclusion: Our study demonstrated utility of pyrazole derivatives as anticonvulsants against epilepsy.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - March 26, 2021 Category: Allergy & Immunology Source Type: research
PKM2 Aggravates Cerebral Ischemia Reperfusion-Induced Neuroinflammation via TLR4/MyD88/TRAF6 Signaling Pathway
Conclusions: Knockdown of PKM2 attenuated cerebral I/R injury through HMGB1-mediated TLR4/MyD88/TRAF6 expression change, providing a potential target for cerebral I/R injury treatment.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - March 19, 2021 Category: Allergy & Immunology Source Type: research
Scopoletin Attenuates Intracerebral Hemorrhage-Induced Brain Injury and Improves Neurological Performance in Rats
Conclusion: Our investigations propose that the effectiveness of scopoletin in improving acute neurological function after ICH is promising, and this could be a lead molecule for the development of treatment plans in ICH treatment.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - March 19, 2021 Category: Allergy & Immunology Source Type: research
Simvastatin Prevents Neurodegeneration in the MPTP Mouse Model of Parkinson ’s Disease via Inhibition of A1 Reactive Astrocytes
Emerging evidence indicates that A1 reactive astrocytes play crucial roles in the pathogenesis of Parkinson ’s disease (PD). Thus, development of agents that could inhibit the formation of A1 reactive astrocytes could be used to treat PD. Simvastatin has been touted as a potential neuroprotective agent for neurologic disorders such as PD, but the specific underlying mechanism remains unclear. The 1-meth yl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and primary astrocytes/neurons were prepared to investigate the effects of simvastatin on PD and its underlying mechanisms in vitro and in vivo. We show that...
Source: Neuroimmunomodulation - March 18, 2021 Category: Allergy & Immunology Source Type: research
Potential Role of Trace Elements (Al, Cu, Zn, and Se) in Multiple Sclerosis Physiopathology
Multiple sclerosis (MS) is an unpredictable disease of the central nervous system. The cause of MS is not known completely, and pathology is specified by involved demyelinated areas in the white and gray matter of the brain and spinal cord. Inflammation and peripheral tolerance breakdown due to Treg cell defects and/or effector cell resistance are present at all stages of the disease. Several invading peripheral immune cells are included in the process of the disease such as macrophages, CD8+ T cells, CD4+ T cells, B cells, and plasma cells. Trace elements are known as elements found in soil, plants, and living organisms i...
Source: Neuroimmunomodulation - March 10, 2021 Category: Allergy & Immunology Source Type: research
Personalized Nutrition for Depression: Impact on the Unholy Trinity
Major depressive disorder (MDD) is a chronic affective disorder that has a strong neuroinflammatory component underpinning its etiology. Recent studies indicate that MDD is also associated with changes in the gut microbiota and that the latter is mainly modulated by diet. Microbiota-based personalized nutrition aims to provide an individual-specific diet that will yield the maximum benefit from a given diet since the gut microbiota is accounted for the variations that individuals present in response to a given food. In this review, we present and discuss 5 possible outcomes of using microbiota-based personalized nutrition....
Source: Neuroimmunomodulation - March 5, 2021 Category: Allergy & Immunology Source Type: research
Anti-Inflammatory Effect of Alpha7 Nicotinic Acetylcholine Receptor Modulators on BV2 Cells
Conclusion: We here identified the dose- and time-dependent effects of LPS in BV2 cell cultures on several inflammatory readouts and showed that α7 nAChR modulators with little or no ion channel activity inhibited this anti-inflammatory mechanism.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - March 3, 2021 Category: Allergy & Immunology Source Type: research
Vitamin D Alleviates Cognitive Dysfunction by Activating the VDR/ERK1/2 Signaling Pathway in an Alzheimer ’s Disease Mouse Model
Conclusion: This study provides new clues about the mechanism by which Vit D exerts neuroprotective effects in an AD mouse model.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - February 18, 2021 Category: Allergy & Immunology Source Type: research
Antiglaucoma Potential of β-Glucogallin Is Mediated by Modulating Mitochondrial Responses in Experimentally Induced Glaucoma
Conclusion: Thus, the results of the present study demonstrate that the use of BG on retinal cells against relieving the intraocular pressure may be a promising therapeutic for controlling the disease progression.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - February 11, 2021 Category: Allergy & Immunology Source Type: research
Expression and Significance of MicroRNA-126 and MicroRNA-21 in Peripheral Blood Mononuclear Cells in Patients with Myasthenia Gravis
Conclusion: Patients with MG have differential expression of microRNA-21 and microRNA-126 and may participate in the pathogenesis of MG by regulating pathways related to inflammatory immune response.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - February 3, 2021 Category: Allergy & Immunology Source Type: research
Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children
COVID-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) betacoronavirus, affects children in a different way than it does in adults, with milder symptoms. However, several cases of neurological symptoms with neuroinflammatory syndromes, such as the multisystem inflammatory syndrome (MIS-C), following mild cases, have been reported. As with other viral infections, such as rubella, influenza, and cytomegalovirus, SARS-CoV-2 induces a surge of proinflammatory cytokines that affect microglial function, which can be harmful to brain development. Along with the viral induction of neuroinflammat...
Source: Neuroimmunomodulation - February 2, 2021 Category: Allergy & Immunology Source Type: research
Local Regulation of Adrenal Steroidogenesis: Subtle in vitro Effects of IL-1 β on the Human Cell Line NCI-H295R Steroid Production along with Changes in MicroRNA Profile and Orphan Nuclear Receptors NR4As
Conclusions: The subtle increase in adrenal steroid production in response to IL-1 β stimulation without any modification in the transcription of the steroidogenic enzymes analyzed suggests an additional inflammatory/anti-inflammatory loop, wherein NR4As receptors may participate. Besides its physiological role, this process might be implied in pathological states accompanied by an unbalanced immune-endocrine relationship.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - January 28, 2021 Category: Allergy & Immunology Source Type: research
The Effect of Exercise and Psychological Stress on Anti- and Proinflammatory Cytokines
Conclusions: Exercise and combination of exercise and psychological stress induce similar acute response to IL-4 in chronic trained and stressed rats. Also, exercise may induce an acute synergistic effect with psychological stress on IL-4.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - January 27, 2021 Category: Allergy & Immunology Source Type: research
Association of Chemokine (C-C Motif) Receptor 5 and Ligand 5 with Recovery from Major Depressive Disorder and Related Neurocognitive Impairment
Discussion: CCR5 and CCL5 are important in the targeting of immune cells by HIV. This is the first study providing valuable hints that both CCR5 and CCL5 might also serve as markers of therapy response prediction in MDD. Regarding neurocognitive impairment in depression, CCR5 and CCL5 did not reveal characteristic changes upon MDD treatment such as executive functions, which are probably delayed. However, changes of emotional perception appear to be an earlier responding feature.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - January 27, 2021 Category: Allergy & Immunology Source Type: research
Publisher's Note
Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - January 12, 2021 Category: Allergy & Immunology Source Type: research
