Effects of the Sympathetic Nervous System on Regulatory T Cell and T Helper 1 Chemokine Expression in Patients with Acute Coronary Syndrome

Objective: To observe the effects of sympathetic overactivity on the immune system involved in the imbalance of T helper (Th) lymphocytes, we investigated the correlation between autonomic dysregulation and the generation of regulatory T (Treg) and Th1 chemokines in patients with acute coronary syndrome (ACS).Methods: Blood samples obtained from patients with coronary artery disease and controls were analyzed for levels of Th1 and Treg cells and their associated cytokines by flow cytometry. In addition, the activity of the cyclic adenosine monophosphate (cAMP), the levels of norepinephrine (NE), epinephrine (EPI) and serum cytokines, and the activity of protein kinase A (PKA) were analyzed by Western blot, radioimmunoassay, high-performance liquid chromatography and enzyme-linked immunoassay, respectively. All subjects were evaluated for heart rate variability (HRV).Results: Levels of Th1 cells and T-bet (a T-box transcription factor), NE, EPI, cAMP and PKA significantly increased (all p
Source: Neuroimmunomodulation - Category: Allergy & Immunology Source Type: research