Natural Phenolic Compounds with Neuroprotective Effects
Neurochem Res. 2023 Nov 8. doi: 10.1007/s11064-023-04046-z. Online ahead of print.ABSTRACTNeurodegenerative disorders are characterized by mitochondrial dysfunction and subsequently oxidative stress, inflammation, and apoptosis that contribute to neuronal cytotoxicity and degeneration. Huntington's (HD), Alzheimer's (AD), and Parkinson's (PD) diseases are three of the major neurodegenerative diseases. To date, researchers have found various natural phytochemicals that could potentially be used to treat neurodegenerative diseases. Particularly, the application of natural phenolic compounds has gained significant traction in...
Source: Neurochemical Research - November 8, 2023 Category: Neuroscience Authors: Mansoureh Tavan Parichehr Hanachi Mar ía de la Luz Cádiz-Gurrea Antonio Segura Carretero Mohammad Hossein Mirjalili Source Type: research
Natural Phenolic Compounds with Neuroprotective Effects
Neurochem Res. 2023 Nov 8. doi: 10.1007/s11064-023-04046-z. Online ahead of print.ABSTRACTNeurodegenerative disorders are characterized by mitochondrial dysfunction and subsequently oxidative stress, inflammation, and apoptosis that contribute to neuronal cytotoxicity and degeneration. Huntington's (HD), Alzheimer's (AD), and Parkinson's (PD) diseases are three of the major neurodegenerative diseases. To date, researchers have found various natural phytochemicals that could potentially be used to treat neurodegenerative diseases. Particularly, the application of natural phenolic compounds has gained significant traction in...
Source: Neurochemical Research - November 8, 2023 Category: Neuroscience Authors: Mansoureh Tavan Parichehr Hanachi Mar ía de la Luz Cádiz-Gurrea Antonio Segura Carretero Mohammad Hossein Mirjalili Source Type: research
Natural Phenolic Compounds with Neuroprotective Effects
Neurochem Res. 2023 Nov 8. doi: 10.1007/s11064-023-04046-z. Online ahead of print.ABSTRACTNeurodegenerative disorders are characterized by mitochondrial dysfunction and subsequently oxidative stress, inflammation, and apoptosis that contribute to neuronal cytotoxicity and degeneration. Huntington's (HD), Alzheimer's (AD), and Parkinson's (PD) diseases are three of the major neurodegenerative diseases. To date, researchers have found various natural phytochemicals that could potentially be used to treat neurodegenerative diseases. Particularly, the application of natural phenolic compounds has gained significant traction in...
Source: Neurochemical Research - November 8, 2023 Category: Neuroscience Authors: Mansoureh Tavan Parichehr Hanachi Mar ía de la Luz Cádiz-Gurrea Antonio Segura Carretero Mohammad Hossein Mirjalili Source Type: research
Natural Phenolic Compounds with Neuroprotective Effects
Neurochem Res. 2023 Nov 8. doi: 10.1007/s11064-023-04046-z. Online ahead of print.ABSTRACTNeurodegenerative disorders are characterized by mitochondrial dysfunction and subsequently oxidative stress, inflammation, and apoptosis that contribute to neuronal cytotoxicity and degeneration. Huntington's (HD), Alzheimer's (AD), and Parkinson's (PD) diseases are three of the major neurodegenerative diseases. To date, researchers have found various natural phytochemicals that could potentially be used to treat neurodegenerative diseases. Particularly, the application of natural phenolic compounds has gained significant traction in...
Source: Neurochemical Research - November 8, 2023 Category: Neuroscience Authors: Mansoureh Tavan Parichehr Hanachi Mar ía de la Luz Cádiz-Gurrea Antonio Segura Carretero Mohammad Hossein Mirjalili Source Type: research
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes
In conclusion, crocetin exerted rapid antidepressant effects via suppressing the expression of inflammatory cytokines and the apoptosis of neuronal cells through PI3K/AKT signaling pathways. The rapid antidepressant effect of crocetin (40 mg/kg) could be maintained for at least 2 days after single treatment.PMID:37935859 | DOI:10.1007/s11064-023-04051-2 (Source: Neurochemical Research)
Source: Neurochemical Research - November 7, 2023 Category: Neuroscience Authors: Susu Lin Ziwei Chen Zhaoruncheng Wu Fei Fei Zijin Xu Yingpeng Tong Wenyu Sun Ping Wang Source Type: research
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes
In conclusion, crocetin exerted rapid antidepressant effects via suppressing the expression of inflammatory cytokines and the apoptosis of neuronal cells through PI3K/AKT signaling pathways. The rapid antidepressant effect of crocetin (40 mg/kg) could be maintained for at least 2 days after single treatment.PMID:37935859 | DOI:10.1007/s11064-023-04051-2 (Source: Neurochemical Research)
Source: Neurochemical Research - November 7, 2023 Category: Neuroscience Authors: Susu Lin Ziwei Chen Zhaoruncheng Wu Fei Fei Zijin Xu Yingpeng Tong Wenyu Sun Ping Wang Source Type: research
Contrasting Iron Metabolism in Undifferentiated Versus Differentiated MO3.13 Oligodendrocytes via IL-1 β-Induced Iron Regulatory Protein 1
This study investigated the influence of interleukin-1β (IL-1β), an elevated proinflammatory cytokine in PD, on iron-related proteins in MO3.13 oligodendrocytes. We found that IL-1β treatment in undifferentiated MO3.13 oligodendrocytes increased iron regulatory protein 1 and transferrin receptor 1 (TfR1) expression while decreasing ferroportin 1 (FPN1) expression. Consequently, iron uptake was enhanced, and iron release was reduced, leading to intracellular iron accumulation. Conversely, IL-1β treatment in differentiated MO3.13 oligodendrocytes exhibited the opposite effect, with decreased TfR1 expression, increased FP...
Source: Neurochemical Research - November 2, 2023 Category: Neuroscience Authors: Jiahua Yang Chenchen Du Yinghui Li Rong Liu Cuiting Jing Junxia Xie Jun Wang Source Type: research
Contrasting Iron Metabolism in Undifferentiated Versus Differentiated MO3.13 Oligodendrocytes via IL-1 β-Induced Iron Regulatory Protein 1
This study investigated the influence of interleukin-1β (IL-1β), an elevated proinflammatory cytokine in PD, on iron-related proteins in MO3.13 oligodendrocytes. We found that IL-1β treatment in undifferentiated MO3.13 oligodendrocytes increased iron regulatory protein 1 and transferrin receptor 1 (TfR1) expression while decreasing ferroportin 1 (FPN1) expression. Consequently, iron uptake was enhanced, and iron release was reduced, leading to intracellular iron accumulation. Conversely, IL-1β treatment in differentiated MO3.13 oligodendrocytes exhibited the opposite effect, with decreased TfR1 expression, increased FP...
Source: Neurochemical Research - November 2, 2023 Category: Neuroscience Authors: Jiahua Yang Chenchen Du Yinghui Li Rong Liu Cuiting Jing Junxia Xie Jun Wang Source Type: research
Contrasting Iron Metabolism in Undifferentiated Versus Differentiated MO3.13 Oligodendrocytes via IL-1 β-Induced Iron Regulatory Protein 1
This study investigated the influence of interleukin-1β (IL-1β), an elevated proinflammatory cytokine in PD, on iron-related proteins in MO3.13 oligodendrocytes. We found that IL-1β treatment in undifferentiated MO3.13 oligodendrocytes increased iron regulatory protein 1 and transferrin receptor 1 (TfR1) expression while decreasing ferroportin 1 (FPN1) expression. Consequently, iron uptake was enhanced, and iron release was reduced, leading to intracellular iron accumulation. Conversely, IL-1β treatment in differentiated MO3.13 oligodendrocytes exhibited the opposite effect, with decreased TfR1 expression, increased FP...
Source: Neurochemical Research - November 2, 2023 Category: Neuroscience Authors: Jiahua Yang Chenchen Du Yinghui Li Rong Liu Cuiting Jing Junxia Xie Jun Wang Source Type: research
Contrasting Iron Metabolism in Undifferentiated Versus Differentiated MO3.13 Oligodendrocytes via IL-1 β-Induced Iron Regulatory Protein 1
This study investigated the influence of interleukin-1β (IL-1β), an elevated proinflammatory cytokine in PD, on iron-related proteins in MO3.13 oligodendrocytes. We found that IL-1β treatment in undifferentiated MO3.13 oligodendrocytes increased iron regulatory protein 1 and transferrin receptor 1 (TfR1) expression while decreasing ferroportin 1 (FPN1) expression. Consequently, iron uptake was enhanced, and iron release was reduced, leading to intracellular iron accumulation. Conversely, IL-1β treatment in differentiated MO3.13 oligodendrocytes exhibited the opposite effect, with decreased TfR1 expression, increased FP...
Source: Neurochemical Research - November 2, 2023 Category: Neuroscience Authors: Jiahua Yang Chenchen Du Yinghui Li Rong Liu Cuiting Jing Junxia Xie Jun Wang Source Type: research
Contrasting Iron Metabolism in Undifferentiated Versus Differentiated MO3.13 Oligodendrocytes via IL-1 β-Induced Iron Regulatory Protein 1
This study investigated the influence of interleukin-1β (IL-1β), an elevated proinflammatory cytokine in PD, on iron-related proteins in MO3.13 oligodendrocytes. We found that IL-1β treatment in undifferentiated MO3.13 oligodendrocytes increased iron regulatory protein 1 and transferrin receptor 1 (TfR1) expression while decreasing ferroportin 1 (FPN1) expression. Consequently, iron uptake was enhanced, and iron release was reduced, leading to intracellular iron accumulation. Conversely, IL-1β treatment in differentiated MO3.13 oligodendrocytes exhibited the opposite effect, with decreased TfR1 expression, increased FP...
Source: Neurochemical Research - November 2, 2023 Category: Neuroscience Authors: Jiahua Yang Chenchen Du Yinghui Li Rong Liu Cuiting Jing Junxia Xie Jun Wang Source Type: research
The Mechanism of α2 adrenoreceptor-dependent Modulation of Neurotransmitter Release at the Neuromuscular Junctions
Neurochem Res. 2023 Oct 28. doi: 10.1007/s11064-023-04052-1. Online ahead of print.ABSTRACTα2-Adrenoreceptors (ARs) are main Gi-protein coupled autoreceptors in sympathetic nerve terminals and targets for dexmedetomidine (DEX), a widely used sedative. We hypothesize that α2-ARs are also potent regulators of neuromuscular transmission via G protein-gated inwardly rectifying potassium (GIRK) channels. Using extracellular microelectrode recording of postsynaptic potentials, we found DEX-induced inhibition of spontaneous and evoked neurotransmitter release as well as desynchronization of evoked exocytotic events in the mouse...
Source: Neurochemical Research - October 28, 2023 Category: Neuroscience Authors: Andrei N Tsentsevitsky Venera F Khuzakhmetova Ellya A Bukharaeva Alexey M Petrov Source Type: research
The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity
Neurochem Res. 2023 Oct 28. doi: 10.1007/s11064-023-04045-0. Online ahead of print.ABSTRACTAluminum is a known neurotoxin and a major environmental contributor to neurodegenerative diseases such as Alzheimer's disease (AD). We uesd a subchronic aluminum chloride exposure model in offspring rats by continuously treating them with AlCl3 solution from the date of birth until day 90 in this research. Then evaluated the neurobehavioral changes in rats, observed the ultrastructural changes of hippocampal synapses and neurons, and examined the level of hippocampal acetylated histone H3 (H3ac), the activity and protein expression ...
Source: Neurochemical Research - October 28, 2023 Category: Neuroscience Authors: Jie Gao Wei Liu Jiaqi Liu Niping Hao Jing Pei Lifeng Zhang Source Type: research
The Mechanism of α2 adrenoreceptor-dependent Modulation of Neurotransmitter Release at the Neuromuscular Junctions
Neurochem Res. 2023 Oct 28. doi: 10.1007/s11064-023-04052-1. Online ahead of print.ABSTRACTα2-Adrenoreceptors (ARs) are main Gi-protein coupled autoreceptors in sympathetic nerve terminals and targets for dexmedetomidine (DEX), a widely used sedative. We hypothesize that α2-ARs are also potent regulators of neuromuscular transmission via G protein-gated inwardly rectifying potassium (GIRK) channels. Using extracellular microelectrode recording of postsynaptic potentials, we found DEX-induced inhibition of spontaneous and evoked neurotransmitter release as well as desynchronization of evoked exocytotic events in the mouse...
Source: Neurochemical Research - October 28, 2023 Category: Neuroscience Authors: Andrei N Tsentsevitsky Venera F Khuzakhmetova Ellya A Bukharaeva Alexey M Petrov Source Type: research
The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity
Neurochem Res. 2023 Oct 28. doi: 10.1007/s11064-023-04045-0. Online ahead of print.ABSTRACTAluminum is a known neurotoxin and a major environmental contributor to neurodegenerative diseases such as Alzheimer's disease (AD). We uesd a subchronic aluminum chloride exposure model in offspring rats by continuously treating them with AlCl3 solution from the date of birth until day 90 in this research. Then evaluated the neurobehavioral changes in rats, observed the ultrastructural changes of hippocampal synapses and neurons, and examined the level of hippocampal acetylated histone H3 (H3ac), the activity and protein expression ...
Source: Neurochemical Research - October 28, 2023 Category: Neuroscience Authors: Jie Gao Wei Liu Jiaqi Liu Niping Hao Jing Pei Lifeng Zhang Source Type: research
