Anti-insomnia Effect of a Polyherbal Formulation on P-chlorophenyalanine Induced Experimental Animal Model
Neurochem Res. 2023 Sep 28. doi: 10.1007/s11064-023-04035-2. Online ahead of print.ABSTRACTSleep is a dynamic and controlled set of physiological and behavioural practices during which the stabilisation and restoration processes of the body take place properly. Therefore, sleep disorders, especially chronic insomnia, can harm an individual's physical and mental health. However, the therapeutic alternatives are limited and possess severe side effects. Thus, in this study, we aimed to investigate the anti-insomnia effect of a polyherbal formulation (Sleep) (SLP) on p-chlorophenyalanine (PCPA) induced insomnia in rats. Intrap...
Source: Neurochemical Research - September 28, 2023 Category: Neuroscience Authors: S Sheethal M Ratheesh Svenia P Jose S Sandya Sarala Samuel Jayashree Madhavan Source Type: research
A Comprehensive Review of Essential Oils and Their Pharmacological Activities in Neurological Disorders: Exploring Neuroprotective Potential
Neurochem Res. 2023 Sep 28. doi: 10.1007/s11064-023-04032-5. Online ahead of print.ABSTRACTNumerous studies have demonstrated essential oils' diverse chemical compositions and pharmacological properties encompassing antinociceptive, anxiolytic-like, and anticonvulsant activities, among other notable effects. The utilization of essential oils, whether inhaled, orally ingested, or applied topically, has commonly been employed as adjunctive therapy for individuals experiencing anxiety, insomnia, convulsions, pain, and cognitive impairment. The utilization of synthetic medications in the treatment of various disorders and symp...
Source: Neurochemical Research - September 28, 2023 Category: Neuroscience Authors: Mohammad Qneibi Sosana Bdir Celine Maayeh Mohammad Bdair Dana Sandouka Diana Basit Mira Hallak Source Type: research
RIP3 in Necroptosis: Underlying Contributions to Traumatic Brain Injury
In this report, we review different domains of RIP3, multiple analyses of necroptosis, and associations between necroptosis and TBI, RIP3, RIP1, and mixed lineage kinase domain-like. Next, we elucidate the potential involvement of RIP3 in TBI and highlight how RIP3 deficiency enhances neuronal function.PMID:37743445 | DOI:10.1007/s11064-023-04038-z (Source: Neurochemical Research)
Source: Neurochemical Research - September 24, 2023 Category: Neuroscience Authors: Lvxia Wang Yong Zhang Min Huang Yiling Yuan Xuehong Liu Source Type: research
RIP3 in Necroptosis: Underlying Contributions to Traumatic Brain Injury
In this report, we review different domains of RIP3, multiple analyses of necroptosis, and associations between necroptosis and TBI, RIP3, RIP1, and mixed lineage kinase domain-like. Next, we elucidate the potential involvement of RIP3 in TBI and highlight how RIP3 deficiency enhances neuronal function.PMID:37743445 | DOI:10.1007/s11064-023-04038-z (Source: Neurochemical Research)
Source: Neurochemical Research - September 24, 2023 Category: Neuroscience Authors: Lvxia Wang Yong Zhang Min Huang Yiling Yuan Xuehong Liu Source Type: research
RIP3 in Necroptosis: Underlying Contributions to Traumatic Brain Injury
In this report, we review different domains of RIP3, multiple analyses of necroptosis, and associations between necroptosis and TBI, RIP3, RIP1, and mixed lineage kinase domain-like. Next, we elucidate the potential involvement of RIP3 in TBI and highlight how RIP3 deficiency enhances neuronal function.PMID:37743445 | DOI:10.1007/s11064-023-04038-z (Source: Neurochemical Research)
Source: Neurochemical Research - September 24, 2023 Category: Neuroscience Authors: Lvxia Wang Yong Zhang Min Huang Yiling Yuan Xuehong Liu Source Type: research
RIP3 in Necroptosis: Underlying Contributions to Traumatic Brain Injury
In this report, we review different domains of RIP3, multiple analyses of necroptosis, and associations between necroptosis and TBI, RIP3, RIP1, and mixed lineage kinase domain-like. Next, we elucidate the potential involvement of RIP3 in TBI and highlight how RIP3 deficiency enhances neuronal function.PMID:37743445 | DOI:10.1007/s11064-023-04038-z (Source: Neurochemical Research)
Source: Neurochemical Research - September 24, 2023 Category: Neuroscience Authors: Lvxia Wang Yong Zhang Min Huang Yiling Yuan Xuehong Liu Source Type: research
Nesfatin-1: A Biomarker and Potential Therapeutic Target in Neurological Disorders
Neurochem Res. 2023 Sep 23. doi: 10.1007/s11064-023-04037-0. Online ahead of print.ABSTRACTNesfatin-1 is a novel adipocytokine consisting of 82 amino acids with anorexic and anti-hyperglycemic properties. Further studies of nesfatin-1 have shown it to be closely associated with neurological disorders. Changes in nesfatin-1 levels are closely linked to the onset, progression and severity of neurological disorders. Nesfatin-1 may affect the development of neurological disorders and can indicate disease evolution and prognosis, thus informing the choice of treatment options. In addition, regulation of the expression or level ...
Source: Neurochemical Research - September 23, 2023 Category: Neuroscience Authors: Siyu Zhou Jianfei Nao Source Type: research
Nesfatin-1: A Biomarker and Potential Therapeutic Target in Neurological Disorders
Neurochem Res. 2023 Sep 23. doi: 10.1007/s11064-023-04037-0. Online ahead of print.ABSTRACTNesfatin-1 is a novel adipocytokine consisting of 82 amino acids with anorexic and anti-hyperglycemic properties. Further studies of nesfatin-1 have shown it to be closely associated with neurological disorders. Changes in nesfatin-1 levels are closely linked to the onset, progression and severity of neurological disorders. Nesfatin-1 may affect the development of neurological disorders and can indicate disease evolution and prognosis, thus informing the choice of treatment options. In addition, regulation of the expression or level ...
Source: Neurochemical Research - September 23, 2023 Category: Neuroscience Authors: Siyu Zhou Jianfei Nao Source Type: research
Byrsonima sericea Ethanol Extract Protected PC12 Cells from the Oxidative Stress and Apoptosis Induced by 6-Hydroxydopamine
This study aimed to evaluate the cytoprotective activity of the B. sericea ethanolic extract (BSEE) against the cytotoxicity induced by 6-hydroxydopamine (6-OHDA) in PC12 cells, an in vitro model of parkinsonism. The identification of phenolic compounds in the extract by HPLC-DAD revealed the presence of geraniin, rutin, isoquercetin, kaempferol 3-O-β-rutinoside, and quercetin. The BSEE (75-300 µg/mL) protected PC12 cells from toxicity induced by 6-OHDA (25 µg/mL), protected cell membrane integrity and showed antioxidant activity. BSEE was able to decrease nitrite levels, glutathione depletion, and protect cells from 6-...
Source: Neurochemical Research - September 19, 2023 Category: Neuroscience Authors: Albert Layo Costa de Assis Patricia de Ara újo Rodrigues Selene Maia de Morais Ana Livya Moreira Rodrigues Jessica Maria Pessoa Gomes Tyciane de Souza Nascimento Alfaete Vieira Oliveira Mayara Sandrielly Soares de Aguiar Geanne Matos de Andrade Source Type: research
Exercise, Spinal Microglia and Neuropathic Pain: Potential Molecular Mechanisms
Neurochem Res. 2023 Sep 19. doi: 10.1007/s11064-023-04025-4. Online ahead of print.ABSTRACTAs one of the most common neuropathic disorders, neuropathic pain often has a negative impact on patients with persistent pain, mood disorders and sleep disturbances. Currently, neuropathic pain is not treated with any specific drug, instead, drugs for other diseases are used as replacements in clinics, but most have adverse effects. In recent years, the role of spinal cord microglia in the pathogenesis of neuropathic pain has been widely recognized, and they are being explored as potential therapeutic targets. Spinal microglia are k...
Source: Neurochemical Research - September 19, 2023 Category: Neuroscience Authors: Min-Jia Wang Xin-Yu Jing Yao-Zheng Wang Bi-Ru Yang Qu Lu Hao Hu Liang Kang Source Type: research
Byrsonima sericea Ethanol Extract Protected PC12 Cells from the Oxidative Stress and Apoptosis Induced by 6-Hydroxydopamine
This study aimed to evaluate the cytoprotective activity of the B. sericea ethanolic extract (BSEE) against the cytotoxicity induced by 6-hydroxydopamine (6-OHDA) in PC12 cells, an in vitro model of parkinsonism. The identification of phenolic compounds in the extract by HPLC-DAD revealed the presence of geraniin, rutin, isoquercetin, kaempferol 3-O-β-rutinoside, and quercetin. The BSEE (75-300 µg/mL) protected PC12 cells from toxicity induced by 6-OHDA (25 µg/mL), protected cell membrane integrity and showed antioxidant activity. BSEE was able to decrease nitrite levels, glutathione depletion, and protect cells from 6-...
Source: Neurochemical Research - September 19, 2023 Category: Neuroscience Authors: Albert Layo Costa de Assis Patricia de Ara újo Rodrigues Selene Maia de Morais Ana Livya Moreira Rodrigues Jessica Maria Pessoa Gomes Tyciane de Souza Nascimento Alfaete Vieira Oliveira Mayara Sandrielly Soares de Aguiar Geanne Matos de Andrade Source Type: research
Exercise, Spinal Microglia and Neuropathic Pain: Potential Molecular Mechanisms
Neurochem Res. 2023 Sep 19. doi: 10.1007/s11064-023-04025-4. Online ahead of print.ABSTRACTAs one of the most common neuropathic disorders, neuropathic pain often has a negative impact on patients with persistent pain, mood disorders and sleep disturbances. Currently, neuropathic pain is not treated with any specific drug, instead, drugs for other diseases are used as replacements in clinics, but most have adverse effects. In recent years, the role of spinal cord microglia in the pathogenesis of neuropathic pain has been widely recognized, and they are being explored as potential therapeutic targets. Spinal microglia are k...
Source: Neurochemical Research - September 19, 2023 Category: Neuroscience Authors: Min-Jia Wang Xin-Yu Jing Yao-Zheng Wang Bi-Ru Yang Qu Lu Hao Hu Liang Kang Source Type: research
Byrsonima sericea Ethanol Extract Protected PC12 Cells from the Oxidative Stress and Apoptosis Induced by 6-Hydroxydopamine
This study aimed to evaluate the cytoprotective activity of the B. sericea ethanolic extract (BSEE) against the cytotoxicity induced by 6-hydroxydopamine (6-OHDA) in PC12 cells, an in vitro model of parkinsonism. The identification of phenolic compounds in the extract by HPLC-DAD revealed the presence of geraniin, rutin, isoquercetin, kaempferol 3-O-β-rutinoside, and quercetin. The BSEE (75-300 µg/mL) protected PC12 cells from toxicity induced by 6-OHDA (25 µg/mL), protected cell membrane integrity and showed antioxidant activity. BSEE was able to decrease nitrite levels, glutathione depletion, and protect cells from 6-...
Source: Neurochemical Research - September 19, 2023 Category: Neuroscience Authors: Albert Layo Costa de Assis Patricia de Ara újo Rodrigues Selene Maia de Morais Ana Livya Moreira Rodrigues Jessica Maria Pessoa Gomes Tyciane de Souza Nascimento Alfaete Vieira Oliveira Mayara Sandrielly Soares de Aguiar Geanne Matos de Andrade Source Type: research
Exercise, Spinal Microglia and Neuropathic Pain: Potential Molecular Mechanisms
Neurochem Res. 2023 Sep 19. doi: 10.1007/s11064-023-04025-4. Online ahead of print.ABSTRACTAs one of the most common neuropathic disorders, neuropathic pain often has a negative impact on patients with persistent pain, mood disorders and sleep disturbances. Currently, neuropathic pain is not treated with any specific drug, instead, drugs for other diseases are used as replacements in clinics, but most have adverse effects. In recent years, the role of spinal cord microglia in the pathogenesis of neuropathic pain has been widely recognized, and they are being explored as potential therapeutic targets. Spinal microglia are k...
Source: Neurochemical Research - September 19, 2023 Category: Neuroscience Authors: Min-Jia Wang Xin-Yu Jing Yao-Zheng Wang Bi-Ru Yang Qu Lu Hao Hu Liang Kang Source Type: research
Byrsonima sericea Ethanol Extract Protected PC12 Cells from the Oxidative Stress and Apoptosis Induced by 6-Hydroxydopamine
This study aimed to evaluate the cytoprotective activity of the B. sericea ethanolic extract (BSEE) against the cytotoxicity induced by 6-hydroxydopamine (6-OHDA) in PC12 cells, an in vitro model of parkinsonism. The identification of phenolic compounds in the extract by HPLC-DAD revealed the presence of geraniin, rutin, isoquercetin, kaempferol 3-O-β-rutinoside, and quercetin. The BSEE (75-300 µg/mL) protected PC12 cells from toxicity induced by 6-OHDA (25 µg/mL), protected cell membrane integrity and showed antioxidant activity. BSEE was able to decrease nitrite levels, glutathione depletion, and protect cells from 6-...
Source: Neurochemical Research - September 19, 2023 Category: Neuroscience Authors: Albert Layo Costa de Assis Patricia de Ara újo Rodrigues Selene Maia de Morais Ana Livya Moreira Rodrigues Jessica Maria Pessoa Gomes Tyciane de Souza Nascimento Alfaete Vieira Oliveira Mayara Sandrielly Soares de Aguiar Geanne Matos de Andrade Source Type: research
