Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes

In conclusion, crocetin exerted rapid antidepressant effects via suppressing the expression of inflammatory cytokines and the apoptosis of neuronal cells through PI3K/AKT signaling pathways. The rapid antidepressant effect of crocetin (40 mg/kg) could be maintained for at least 2 days after single treatment.PMID:37935859 | DOI:10.1007/s11064-023-04051-2

Source: Neurochemical Research - November 7, 2023 Category: Neuroscience Authors: Susu Lin Ziwei Chen Zhaoruncheng Wu Fei Fei Zijin Xu Yingpeng Tong Wenyu Sun Ping Wang Source Type: research