Exercise, Spinal Microglia and Neuropathic Pain: Potential Molecular Mechanisms
Neurochem Res. 2023 Sep 19. doi: 10.1007/s11064-023-04025-4. Online ahead of print.ABSTRACTAs one of the most common neuropathic disorders, neuropathic pain often has a negative impact on patients with persistent pain, mood disorders and sleep disturbances. Currently, neuropathic pain is not treated with any specific drug, instead, drugs for other diseases are used as replacements in clinics, but most have adverse effects. In recent years, the role of spinal cord microglia in the pathogenesis of neuropathic pain has been widely recognized, and they are being explored as potential therapeutic targets. Spinal microglia are k...
Source: Neurochemical Research - September 19, 2023 Category: Neuroscience Authors: Min-Jia Wang Xin-Yu Jing Yao-Zheng Wang Bi-Ru Yang Qu Lu Hao Hu Liang Kang Source Type: research
Silencing of LINC00707 Alleviates Brain Injury by Targeting miR-30a-5p to Regulate Microglia Inflammation and Apoptosis
Neurochem Res. 2023 Sep 16. doi: 10.1007/s11064-023-04029-0. Online ahead of print.ABSTRACTThe role of microglia in traumatic brain injury (TBI) has gained considerable attention. The present study aims to elucidate the potential mechanisms of Long intergenic non-protein coding RNA 707 (LINC00707) in TBI-induced microglia activation and inflammatory factor release. An in vivo model of rat TBI and in vitro microglia model was established using Controlled cortex injury (CCI) and lipopolysaccharide (LPS) stimulation. RT-qPCR to detect LINC00707 levels in rat cerebral cortex or cells. Modified Neurological Impairment Score (mN...
Source: Neurochemical Research - September 16, 2023 Category: Neuroscience Authors: Wei Hu Jiang Zhou Yiqing Jiang Zeyu Bao Xiaoming Hu Source Type: research
Research Progress on the Antidepressant Effects of Baicalin and Its Aglycone Baicalein: A Systematic Review of the Biological Mechanisms
Neurochem Res. 2023 Sep 16. doi: 10.1007/s11064-023-04026-3. Online ahead of print.ABSTRACTDepression is the most prevalent mental disorder, affecting more than 300 million adults worldwide each year, which can lead to serious economic and social problems. Antidepressants are usually the first-line treatment for depression, however, traditional antidepressants on the market have the disadvantage of low remission rates and may cause side effects to patients, therefore, the current focus in the field of depression is to develop novel therapeutic agents with high remission rates and few side effects. In this context, the anti...
Source: Neurochemical Research - September 16, 2023 Category: Neuroscience Authors: Chen Wang Ming-Qi Gao Source Type: research
Silencing of LINC00707 Alleviates Brain Injury by Targeting miR-30a-5p to Regulate Microglia Inflammation and Apoptosis
Neurochem Res. 2023 Sep 16. doi: 10.1007/s11064-023-04029-0. Online ahead of print.ABSTRACTThe role of microglia in traumatic brain injury (TBI) has gained considerable attention. The present study aims to elucidate the potential mechanisms of Long intergenic non-protein coding RNA 707 (LINC00707) in TBI-induced microglia activation and inflammatory factor release. An in vivo model of rat TBI and in vitro microglia model was established using Controlled cortex injury (CCI) and lipopolysaccharide (LPS) stimulation. RT-qPCR to detect LINC00707 levels in rat cerebral cortex or cells. Modified Neurological Impairment Score (mN...
Source: Neurochemical Research - September 16, 2023 Category: Neuroscience Authors: Wei Hu Jiang Zhou Yiqing Jiang Zeyu Bao Xiaoming Hu Source Type: research
Research Progress on the Antidepressant Effects of Baicalin and Its Aglycone Baicalein: A Systematic Review of the Biological Mechanisms
Neurochem Res. 2023 Sep 16. doi: 10.1007/s11064-023-04026-3. Online ahead of print.ABSTRACTDepression is the most prevalent mental disorder, affecting more than 300 million adults worldwide each year, which can lead to serious economic and social problems. Antidepressants are usually the first-line treatment for depression, however, traditional antidepressants on the market have the disadvantage of low remission rates and may cause side effects to patients, therefore, the current focus in the field of depression is to develop novel therapeutic agents with high remission rates and few side effects. In this context, the anti...
Source: Neurochemical Research - September 16, 2023 Category: Neuroscience Authors: Chen Wang Ming-Qi Gao Source Type: research
