Contrasting Iron Metabolism in Undifferentiated Versus Differentiated MO3.13 Oligodendrocytes via IL-1 β-Induced Iron Regulatory Protein 1
This study investigated the influence of interleukin-1β (IL-1β), an elevated proinflammatory cytokine in PD, on iron-related proteins in MO3.13 oligodendrocytes. We found that IL-1β treatment in undifferentiated MO3.13 oligodendrocytes increased iron regulatory protein 1 and transferrin receptor 1 (TfR1) expression while decreasing ferroportin 1 (FPN1) expression. Consequently, iron uptake was enhanced, and iron release was reduced, leading to intracellular iron accumulation. Conversely, IL-1β treatment in differentiated MO3.13 oligodendrocytes exhibited the opposite effect, with decreased TfR1 expression, increased FP...
Source: Neurochemical Research - November 2, 2023 Category: Neuroscience Authors: Jiahua Yang Chenchen Du Yinghui Li Rong Liu Cuiting Jing Junxia Xie Jun Wang Source Type: research

The Mechanism of α2 adrenoreceptor-dependent Modulation of Neurotransmitter Release at the Neuromuscular Junctions
Neurochem Res. 2023 Oct 28. doi: 10.1007/s11064-023-04052-1. Online ahead of print.ABSTRACTα2-Adrenoreceptors (ARs) are main Gi-protein coupled autoreceptors in sympathetic nerve terminals and targets for dexmedetomidine (DEX), a widely used sedative. We hypothesize that α2-ARs are also potent regulators of neuromuscular transmission via G protein-gated inwardly rectifying potassium (GIRK) channels. Using extracellular microelectrode recording of postsynaptic potentials, we found DEX-induced inhibition of spontaneous and evoked neurotransmitter release as well as desynchronization of evoked exocytotic events in the mouse...
Source: Neurochemical Research - October 28, 2023 Category: Neuroscience Authors: Andrei N Tsentsevitsky Venera F Khuzakhmetova Ellya A Bukharaeva Alexey M Petrov Source Type: research

The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity
Neurochem Res. 2023 Oct 28. doi: 10.1007/s11064-023-04045-0. Online ahead of print.ABSTRACTAluminum is a known neurotoxin and a major environmental contributor to neurodegenerative diseases such as Alzheimer's disease (AD). We uesd a subchronic aluminum chloride exposure model in offspring rats by continuously treating them with AlCl3 solution from the date of birth until day 90 in this research. Then evaluated the neurobehavioral changes in rats, observed the ultrastructural changes of hippocampal synapses and neurons, and examined the level of hippocampal acetylated histone H3 (H3ac), the activity and protein expression ...
Source: Neurochemical Research - October 28, 2023 Category: Neuroscience Authors: Jie Gao Wei Liu Jiaqi Liu Niping Hao Jing Pei Lifeng Zhang Source Type: research

The Mechanism of α2 adrenoreceptor-dependent Modulation of Neurotransmitter Release at the Neuromuscular Junctions
Neurochem Res. 2023 Oct 28. doi: 10.1007/s11064-023-04052-1. Online ahead of print.ABSTRACTα2-Adrenoreceptors (ARs) are main Gi-protein coupled autoreceptors in sympathetic nerve terminals and targets for dexmedetomidine (DEX), a widely used sedative. We hypothesize that α2-ARs are also potent regulators of neuromuscular transmission via G protein-gated inwardly rectifying potassium (GIRK) channels. Using extracellular microelectrode recording of postsynaptic potentials, we found DEX-induced inhibition of spontaneous and evoked neurotransmitter release as well as desynchronization of evoked exocytotic events in the mouse...
Source: Neurochemical Research - October 28, 2023 Category: Neuroscience Authors: Andrei N Tsentsevitsky Venera F Khuzakhmetova Ellya A Bukharaeva Alexey M Petrov Source Type: research

The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity
Neurochem Res. 2023 Oct 28. doi: 10.1007/s11064-023-04045-0. Online ahead of print.ABSTRACTAluminum is a known neurotoxin and a major environmental contributor to neurodegenerative diseases such as Alzheimer's disease (AD). We uesd a subchronic aluminum chloride exposure model in offspring rats by continuously treating them with AlCl3 solution from the date of birth until day 90 in this research. Then evaluated the neurobehavioral changes in rats, observed the ultrastructural changes of hippocampal synapses and neurons, and examined the level of hippocampal acetylated histone H3 (H3ac), the activity and protein expression ...
Source: Neurochemical Research - October 28, 2023 Category: Neuroscience Authors: Jie Gao Wei Liu Jiaqi Liu Niping Hao Jing Pei Lifeng Zhang Source Type: research

The Mechanism of α2 adrenoreceptor-dependent Modulation of Neurotransmitter Release at the Neuromuscular Junctions
Neurochem Res. 2023 Oct 28. doi: 10.1007/s11064-023-04052-1. Online ahead of print.ABSTRACTα2-Adrenoreceptors (ARs) are main Gi-protein coupled autoreceptors in sympathetic nerve terminals and targets for dexmedetomidine (DEX), a widely used sedative. We hypothesize that α2-ARs are also potent regulators of neuromuscular transmission via G protein-gated inwardly rectifying potassium (GIRK) channels. Using extracellular microelectrode recording of postsynaptic potentials, we found DEX-induced inhibition of spontaneous and evoked neurotransmitter release as well as desynchronization of evoked exocytotic events in the mouse...
Source: Neurochemical Research - October 28, 2023 Category: Neuroscience Authors: Andrei N Tsentsevitsky Venera F Khuzakhmetova Ellya A Bukharaeva Alexey M Petrov Source Type: research

The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity
Neurochem Res. 2023 Oct 28. doi: 10.1007/s11064-023-04045-0. Online ahead of print.ABSTRACTAluminum is a known neurotoxin and a major environmental contributor to neurodegenerative diseases such as Alzheimer's disease (AD). We uesd a subchronic aluminum chloride exposure model in offspring rats by continuously treating them with AlCl3 solution from the date of birth until day 90 in this research. Then evaluated the neurobehavioral changes in rats, observed the ultrastructural changes of hippocampal synapses and neurons, and examined the level of hippocampal acetylated histone H3 (H3ac), the activity and protein expression ...
Source: Neurochemical Research - October 28, 2023 Category: Neuroscience Authors: Jie Gao Wei Liu Jiaqi Liu Niping Hao Jing Pei Lifeng Zhang Source Type: research

The Mechanism of α2 adrenoreceptor-dependent Modulation of Neurotransmitter Release at the Neuromuscular Junctions
Neurochem Res. 2023 Oct 28. doi: 10.1007/s11064-023-04052-1. Online ahead of print.ABSTRACTα2-Adrenoreceptors (ARs) are main Gi-protein coupled autoreceptors in sympathetic nerve terminals and targets for dexmedetomidine (DEX), a widely used sedative. We hypothesize that α2-ARs are also potent regulators of neuromuscular transmission via G protein-gated inwardly rectifying potassium (GIRK) channels. Using extracellular microelectrode recording of postsynaptic potentials, we found DEX-induced inhibition of spontaneous and evoked neurotransmitter release as well as desynchronization of evoked exocytotic events in the mouse...
Source: Neurochemical Research - October 28, 2023 Category: Neuroscience Authors: Andrei N Tsentsevitsky Venera F Khuzakhmetova Ellya A Bukharaeva Alexey M Petrov Source Type: research

The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity
Neurochem Res. 2023 Oct 28. doi: 10.1007/s11064-023-04045-0. Online ahead of print.ABSTRACTAluminum is a known neurotoxin and a major environmental contributor to neurodegenerative diseases such as Alzheimer's disease (AD). We uesd a subchronic aluminum chloride exposure model in offspring rats by continuously treating them with AlCl3 solution from the date of birth until day 90 in this research. Then evaluated the neurobehavioral changes in rats, observed the ultrastructural changes of hippocampal synapses and neurons, and examined the level of hippocampal acetylated histone H3 (H3ac), the activity and protein expression ...
Source: Neurochemical Research - October 28, 2023 Category: Neuroscience Authors: Jie Gao Wei Liu Jiaqi Liu Niping Hao Jing Pei Lifeng Zhang Source Type: research

Increased Expression of K < sub > Na < /sub > 1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Injury
Neurochem Res. 2023 Oct 25. doi: 10.1007/s11064-023-04044-1. Online ahead of print.ABSTRACTRecent studies have indicated that functional abnormalities in the KNa1.2 channel are linked to epileptic encephalopathies. However, the role of KNa1.2 channel in traumatic brain injury (TBI) remains limited. We collected brain tissue from the TBI mice and patients with post-traumatic epilepsy (PTE) to determine changes in KNa1.2 channel following TBI. We also investigated whether the MAPK pathway, which was activated by the released cytokines after injury, regulated KNa1.2 channel in in vitro. Finally, to elucidate the physiological...
Source: Neurochemical Research - October 24, 2023 Category: Neuroscience Authors: Ru Liu Lei Sun Xiaorui Shi Ci Li Xi Guo Yingting Wang Xiu Wang Kai Zhang Yongjun Wang Qun Wang Jianping Wu Source Type: research

Increased Expression of K < sub > Na < /sub > 1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Injury
Neurochem Res. 2023 Oct 25. doi: 10.1007/s11064-023-04044-1. Online ahead of print.ABSTRACTRecent studies have indicated that functional abnormalities in the KNa1.2 channel are linked to epileptic encephalopathies. However, the role of KNa1.2 channel in traumatic brain injury (TBI) remains limited. We collected brain tissue from the TBI mice and patients with post-traumatic epilepsy (PTE) to determine changes in KNa1.2 channel following TBI. We also investigated whether the MAPK pathway, which was activated by the released cytokines after injury, regulated KNa1.2 channel in in vitro. Finally, to elucidate the physiological...
Source: Neurochemical Research - October 24, 2023 Category: Neuroscience Authors: Ru Liu Lei Sun Xiaorui Shi Ci Li Xi Guo Yingting Wang Xiu Wang Kai Zhang Yongjun Wang Qun Wang Jianping Wu Source Type: research

Increased Expression of K < sub > Na < /sub > 1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Injury
Neurochem Res. 2023 Oct 25. doi: 10.1007/s11064-023-04044-1. Online ahead of print.ABSTRACTRecent studies have indicated that functional abnormalities in the KNa1.2 channel are linked to epileptic encephalopathies. However, the role of KNa1.2 channel in traumatic brain injury (TBI) remains limited. We collected brain tissue from the TBI mice and patients with post-traumatic epilepsy (PTE) to determine changes in KNa1.2 channel following TBI. We also investigated whether the MAPK pathway, which was activated by the released cytokines after injury, regulated KNa1.2 channel in in vitro. Finally, to elucidate the physiological...
Source: Neurochemical Research - October 24, 2023 Category: Neuroscience Authors: Ru Liu Lei Sun Xiaorui Shi Ci Li Xi Guo Yingting Wang Xiu Wang Kai Zhang Yongjun Wang Qun Wang Jianping Wu Source Type: research

Increased Expression of K < sub > Na < /sub > 1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Injury
Neurochem Res. 2023 Oct 25. doi: 10.1007/s11064-023-04044-1. Online ahead of print.ABSTRACTRecent studies have indicated that functional abnormalities in the KNa1.2 channel are linked to epileptic encephalopathies. However, the role of KNa1.2 channel in traumatic brain injury (TBI) remains limited. We collected brain tissue from the TBI mice and patients with post-traumatic epilepsy (PTE) to determine changes in KNa1.2 channel following TBI. We also investigated whether the MAPK pathway, which was activated by the released cytokines after injury, regulated KNa1.2 channel in in vitro. Finally, to elucidate the physiological...
Source: Neurochemical Research - October 24, 2023 Category: Neuroscience Authors: Ru Liu Lei Sun Xiaorui Shi Ci Li Xi Guo Yingting Wang Xiu Wang Kai Zhang Yongjun Wang Qun Wang Jianping Wu Source Type: research

Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation
This study provides a novel therapeutic approach to reduce the side effects of MPH.PMID:37864024 | DOI:10.1007/s11064-023-04043-2 (Source: Neurochemical Research)
Source: Neurochemical Research - October 20, 2023 Category: Neuroscience Authors: Shahrzad Molavinia Mehrad Nikravesh Marzieh Pashmforoosh Hossein Rajabi Vardanjani Mohammad Javad Khodayar Source Type: research

Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation
This study provides a novel therapeutic approach to reduce the side effects of MPH.PMID:37864024 | DOI:10.1007/s11064-023-04043-2 (Source: Neurochemical Research)
Source: Neurochemical Research - October 20, 2023 Category: Neuroscience Authors: Shahrzad Molavinia Mehrad Nikravesh Marzieh Pashmforoosh Hossein Rajabi Vardanjani Mohammad Javad Khodayar Source Type: research