The Pulsed Nd:YAG Laser Therapy Enhanced Nerve Regeneration via Apoptosis Inhibition in a Rat Crushed Sciatic Nerve Model
Neurochem Res. 2023 Dec 29. doi: 10.1007/s11064-023-04068-7. Online ahead of print.ABSTRACTThe study was aimed to validate the efficacy of the pulsed Nd:YAG laser on nerve regeneration in a rat sciatic nerve crushed model. 54 Wistar rats were randomly assigned into three groups: shame control, crush control, and laser treated group. For the laser treated group, the pulsed Nd:YAG laser (10 Hz) with 350 mJ per pulse in energy density and 50 J/cm2 in fluence was applied extracorporeally at the lesion site for 12 min to daily deliver 500 J immediately and consecutive 9 days following the crush injury. At week 1, the apoptosis-...
Source: Neurochemical Research - December 29, 2023 Category: Neuroscience Authors: Po-Yen Ko Che-Chia Hsu Shih-Yao Chen Chia-Lung Li I-Ming Jou Po-Ting Wu Source Type: research
Differential Effects of Neonatal Ventral Hippocampus Lesion on Behavior and Corticolimbic Plasticity in Wistar-Kyoto and Spontaneously Hypertensive Rats
Neurochem Res. 2023 Dec 29. doi: 10.1007/s11064-023-04074-9. Online ahead of print.ABSTRACTDysfunction of the corticolimbic system, particularly at the dendritic spine level, is a recognized core mechanism in neurodevelopmental disorders such as schizophrenia. Neonatal ventral hippocampus lesion (NVHL) in Sprague-Dawley rats induces both a schizophrenia-related behavioral phenotype and dendritic spine pathology (reduced total number and mature spines) in corticolimbic areas, which is mitigated by antipsychotics. However, there is limited information on the impact of rat strain on NVHL outcomes and antipsychotic effects. We...
Source: Neurochemical Research - December 29, 2023 Category: Neuroscience Authors: Hiram Tendilla-Beltr án Linda Garc és-Ramírez Edwin Mart ínez-Vásquez Andrea Nakakawa Ma de Jes ús Gómez-Villalobos Gonzalo Flores Source Type: research
Correction to: NL ‑1 Promotes PINK1‑Parkin‑Mediated Mitophagy through MitoNEET Inhibition in Subarachnoid Hemorrhage
Neurochem Res. 2023 Dec 29. doi: 10.1007/s11064-023-04091-8. Online ahead of print.NO ABSTRACTPMID:38155320 | DOI:10.1007/s11064-023-04091-8 (Source: Neurochemical Research)
Source: Neurochemical Research - December 28, 2023 Category: Neuroscience Authors: Tongyu Zhang Minghai Zhang Source Type: research
Correction to: NL ‑1 Promotes PINK1‑Parkin‑Mediated Mitophagy through MitoNEET Inhibition in Subarachnoid Hemorrhage
Neurochem Res. 2023 Dec 29. doi: 10.1007/s11064-023-04091-8. Online ahead of print.NO ABSTRACTPMID:38155320 | DOI:10.1007/s11064-023-04091-8 (Source: Neurochemical Research)
Source: Neurochemical Research - December 28, 2023 Category: Neuroscience Authors: Tongyu Zhang Minghai Zhang Source Type: research
Correction to: NL ‑1 Promotes PINK1‑Parkin‑Mediated Mitophagy through MitoNEET Inhibition in Subarachnoid Hemorrhage
Neurochem Res. 2023 Dec 29. doi: 10.1007/s11064-023-04091-8. Online ahead of print.NO ABSTRACTPMID:38155320 | DOI:10.1007/s11064-023-04091-8 (Source: Neurochemical Research)
Source: Neurochemical Research - December 28, 2023 Category: Neuroscience Authors: Tongyu Zhang Minghai Zhang Source Type: research
Correction to: NL ‑1 Promotes PINK1‑Parkin‑Mediated Mitophagy through MitoNEET Inhibition in Subarachnoid Hemorrhage
Neurochem Res. 2023 Dec 29. doi: 10.1007/s11064-023-04091-8. Online ahead of print.NO ABSTRACTPMID:38155320 | DOI:10.1007/s11064-023-04091-8 (Source: Neurochemical Research)
Source: Neurochemical Research - December 28, 2023 Category: Neuroscience Authors: Tongyu Zhang Minghai Zhang Source Type: research
Cannabidiol and Tetrahydrocannabinol Antinociceptive Activity is Mediated by Distinct Receptors in Caenorhabditis elegans
In this study, we used Caenorhabditis elegans, an ideal model organism for the study of nociception that expresses mammal ortholog cannabinoid (NPR-19 and NPR-32) and vanilloid (OSM-9 and OCR-2) receptors. Here, we evaluated the antinociceptive activity of THC and CBD, identifying receptor targets and several metabolic pathways activated following exposure to these molecules. The thermal avoidance index was used to phenotype each tested C. elegans experimental group. The data revealed for the first time that THC and CBD decreases the nocifensive response of C. elegans to noxious heat (32-35 °C). The effect was reversed 6 ...
Source: Neurochemical Research - December 23, 2023 Category: Neuroscience Authors: Fatma Boujenoui Bruno Nkambeu Jennifer Ben Salem Jesus David Castano Uruena Francis Beaudry Source Type: research
Cannabidiol and Tetrahydrocannabinol Antinociceptive Activity is Mediated by Distinct Receptors in Caenorhabditis elegans
In this study, we used Caenorhabditis elegans, an ideal model organism for the study of nociception that expresses mammal ortholog cannabinoid (NPR-19 and NPR-32) and vanilloid (OSM-9 and OCR-2) receptors. Here, we evaluated the antinociceptive activity of THC and CBD, identifying receptor targets and several metabolic pathways activated following exposure to these molecules. The thermal avoidance index was used to phenotype each tested C. elegans experimental group. The data revealed for the first time that THC and CBD decreases the nocifensive response of C. elegans to noxious heat (32-35 °C). The effect was reversed 6 ...
Source: Neurochemical Research - December 23, 2023 Category: Neuroscience Authors: Fatma Boujenoui Bruno Nkambeu Jennifer Ben Salem Jesus David Castano Uruena Francis Beaudry Source Type: research
Cannabidiol and Tetrahydrocannabinol Antinociceptive Activity is Mediated by Distinct Receptors in Caenorhabditis elegans
In this study, we used Caenorhabditis elegans, an ideal model organism for the study of nociception that expresses mammal ortholog cannabinoid (NPR-19 and NPR-32) and vanilloid (OSM-9 and OCR-2) receptors. Here, we evaluated the antinociceptive activity of THC and CBD, identifying receptor targets and several metabolic pathways activated following exposure to these molecules. The thermal avoidance index was used to phenotype each tested C. elegans experimental group. The data revealed for the first time that THC and CBD decreases the nocifensive response of C. elegans to noxious heat (32-35 °C). The effect was reversed 6 ...
Source: Neurochemical Research - December 23, 2023 Category: Neuroscience Authors: Fatma Boujenoui Bruno Nkambeu Jennifer Ben Salem Jesus David Castano Uruena Francis Beaudry Source Type: research
Cannabidiol and Tetrahydrocannabinol Antinociceptive Activity is Mediated by Distinct Receptors in Caenorhabditis elegans
In this study, we used Caenorhabditis elegans, an ideal model organism for the study of nociception that expresses mammal ortholog cannabinoid (NPR-19 and NPR-32) and vanilloid (OSM-9 and OCR-2) receptors. Here, we evaluated the antinociceptive activity of THC and CBD, identifying receptor targets and several metabolic pathways activated following exposure to these molecules. The thermal avoidance index was used to phenotype each tested C. elegans experimental group. The data revealed for the first time that THC and CBD decreases the nocifensive response of C. elegans to noxious heat (32-35 °C). The effect was reversed 6 ...
Source: Neurochemical Research - December 23, 2023 Category: Neuroscience Authors: Fatma Boujenoui Bruno Nkambeu Jennifer Ben Salem Jesus David Castano Uruena Francis Beaudry Source Type: research
Cannabidiol and Tetrahydrocannabinol Antinociceptive Activity is Mediated by Distinct Receptors in Caenorhabditis elegans
In this study, we used Caenorhabditis elegans, an ideal model organism for the study of nociception that expresses mammal ortholog cannabinoid (NPR-19 and NPR-32) and vanilloid (OSM-9 and OCR-2) receptors. Here, we evaluated the antinociceptive activity of THC and CBD, identifying receptor targets and several metabolic pathways activated following exposure to these molecules. The thermal avoidance index was used to phenotype each tested C. elegans experimental group. The data revealed for the first time that THC and CBD decreases the nocifensive response of C. elegans to noxious heat (32-35 °C). The effect was reversed 6 ...
Source: Neurochemical Research - December 23, 2023 Category: Neuroscience Authors: Fatma Boujenoui Bruno Nkambeu Jennifer Ben Salem Jesus David Castano Uruena Francis Beaudry Source Type: research
Neuroprotective and Anti-inflammatory Effects of Rubiscolin-6 Analogs with Proline Surrogates in Position 2
Neurochem Res. 2023 Dec 20. doi: 10.1007/s11064-023-04070-z. Online ahead of print.ABSTRACTNaturally occurring peptides, such as rubiscolins derived from spinach leaves, have been shown to possess some interesting activities. They exerted central effects, such as antinociception, memory consolidation and anxiolytic-like activity. The fact that rubiscolins are potent even when given orally makes them very promising drug candidates. The present work tested whether rubiscolin-6 (R-6, Tyr-Pro-Leu-Asp-Leu-Phe) analogs have neuroprotective and anti-inflammatory effects. These hypotheses were tested in the 6-hydroxydopamine (6-OH...
Source: Neurochemical Research - December 20, 2023 Category: Neuroscience Authors: Renata Perlikowska Joana Silva Celso Alves Patricia Susano Ma łgorzata Zakłos-Szyda Agnieszka Skibska Anna Adamska-Bart łomiejczyk Karol Wtorek Jean-Claude do Rego Jean-Luc do Rego Alicja Kluczyk Rui Pedrosa Source Type: research
Neuroprotective and Anti-inflammatory Effects of Rubiscolin-6 Analogs with Proline Surrogates in Position 2
Neurochem Res. 2023 Dec 20. doi: 10.1007/s11064-023-04070-z. Online ahead of print.ABSTRACTNaturally occurring peptides, such as rubiscolins derived from spinach leaves, have been shown to possess some interesting activities. They exerted central effects, such as antinociception, memory consolidation and anxiolytic-like activity. The fact that rubiscolins are potent even when given orally makes them very promising drug candidates. The present work tested whether rubiscolin-6 (R-6, Tyr-Pro-Leu-Asp-Leu-Phe) analogs have neuroprotective and anti-inflammatory effects. These hypotheses were tested in the 6-hydroxydopamine (6-OH...
Source: Neurochemical Research - December 20, 2023 Category: Neuroscience Authors: Renata Perlikowska Joana Silva Celso Alves Patricia Susano Ma łgorzata Zakłos-Szyda Agnieszka Skibska Anna Adamska-Bart łomiejczyk Karol Wtorek Jean-Claude do Rego Jean-Luc do Rego Alicja Kluczyk Rui Pedrosa Source Type: research
Neuroprotective and Anti-inflammatory Effects of Rubiscolin-6 Analogs with Proline Surrogates in Position 2
Neurochem Res. 2023 Dec 20. doi: 10.1007/s11064-023-04070-z. Online ahead of print.ABSTRACTNaturally occurring peptides, such as rubiscolins derived from spinach leaves, have been shown to possess some interesting activities. They exerted central effects, such as antinociception, memory consolidation and anxiolytic-like activity. The fact that rubiscolins are potent even when given orally makes them very promising drug candidates. The present work tested whether rubiscolin-6 (R-6, Tyr-Pro-Leu-Asp-Leu-Phe) analogs have neuroprotective and anti-inflammatory effects. These hypotheses were tested in the 6-hydroxydopamine (6-OH...
Source: Neurochemical Research - December 20, 2023 Category: Neuroscience Authors: Renata Perlikowska Joana Silva Celso Alves Patricia Susano Ma łgorzata Zakłos-Szyda Agnieszka Skibska Anna Adamska-Bart łomiejczyk Karol Wtorek Jean-Claude do Rego Jean-Luc do Rego Alicja Kluczyk Rui Pedrosa Source Type: research
Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4
Neurochem Res. 2023 Dec 19. doi: 10.1007/s11064-023-04075-8. Online ahead of print.ABSTRACTTherapeutic hypothermia (TH) provides neuroprotection. However, the cellular mechanisms underlying the neuroprotective effects of TH are not fully elucidated. Regulation of microglial activation has the potential to treat a variety of nervous system diseases. Transient receptor potential vanilloid 4 (TRPV4), a nonselective cation channel, is activated by temperature stimulus at 27-35 °C. Although it is speculated that TRPV4 is associated with the neuroprotective mechanisms of TH, the role of TRPV4 in the neuroprotective effects of T...
Source: Neurochemical Research - December 19, 2023 Category: Neuroscience Authors: Naoya Fukuda Kohki Toriuchi Rina Mimoto Hiromasa Aoki Hiroki Kakita Yoshiaki Suzuki Satoru Takeshita Tetsuya Tamura Hisao Yamamura Yasumichi Inoue Hidetoshi Hayashi Yasumasa Yamada Mineyoshi Aoyama Source Type: research
