Interleukin 3 Inhibits Glutamate-Cytotoxicity in Neuroblastoma Cell Line
In this study, we uncover the protective role of IL-3 as an inhibitor of glutamate-induced cell death, analyzing the cytokine's signaling pathways during its protective effect. Specifically, we examined the relevance of JAK/STAT, Ras/MAPK, and PI3 K signaling pathways in the molecular mechanism triggered by IL-3. Our results show that the inhibition of JAK, ERK, and PI3 K signaling pathways, using pharmacological inhibitors, effectively blocked IL-3's protective role against glutamate-induced cell death. Additionally, our findings suggest that Bcl-2 and Bax proteins may be involved in the molecular mechanism triggered by I...
Source: Neurochemical Research - March 21, 2024 Category: Neuroscience Authors: Ver ónica Matus Marcos Castro-Guarda Joaqu ín Cárcamo-Fierro Francisco J Morera Angara Zambrano Source Type: research
Ferritinophagy-Mediated Hippocampus Ferroptosis is Involved in Cognitive Impairment in Immature Rats Induced by Hypoxia Combined with Propofol
In this study, our in vivo experiments found that immature rats exposed to hypoxia combined with propofol (HCWP) could develop cognitive impairment. We performed the RNA-seq analysis of its hippocampal tissues and found that autophagy and ferroptosis may play a role in our model. Next, we verified the participation of the two modes of death by detecting the expression of autophagy-related indexes Sequestosome 1 (SQSTM1) and Beclin1, and ferroptosis-related indicators Fe2+, reactive oxygen species (ROS) and glutathione peroxidase 4 (GPX4). Meanwhile, we found that ferrostatin-1 (Fer-1), an inhibitor of ferroptosis, could im...
Source: Neurochemical Research - March 21, 2024 Category: Neuroscience Authors: Ling Liu Wen Gao Shun Yang Fei Yang Shangyingying Li Yaqiong Tian Li Yang Qianyu Deng Zhengwei Gan Shengfen Tu Source Type: research
Ashwagandha Diminishes Hippocampal Apoptosis Induced by Microwave Radiation by Acetylcholinesterase Dependent Neuro-Inflammatory Pathway in Male Coturnix coturnix Japonica
In conclusion, this study showed that MWR induces apoptosis and oxidative stress in the brain, while ASW reduces excessive ROS production, prevents neurodegeneration and promotes neuronal health.PMID:38506951 | DOI:10.1007/s11064-024-04127-7 (Source: Neurochemical Research)
Source: Neurochemical Research - March 20, 2024 Category: Neuroscience Authors: Vaibhav Gupta Rashmi Srivastava Source Type: research
6-Hydroxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline Demonstrates Neuroprotective Properties in Experimental Parkinson's Disease by Enhancing the Antioxidant System, Normalising Chaperone Activity and Suppressing Apoptosis
Neurochem Res. 2024 Mar 19. doi: 10.1007/s11064-024-04125-9. Online ahead of print.ABSTRACTParkinson's disease (PD) is a neurodegenerative disease, whereby disturbances within the antioxidant defence system, increased aggregation of proteins, and activation of neuronal apoptosis all have a crucial role in the pathogenesis. In this context, exploring the neuroprotective capabilities of compounds that sustain the effectiveness of cellular defence systems in neurodegenerative disorders is worthwhile. During this study, we assessed how 6-hydroxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline (HTHQ), which has antioxidant properti...
Source: Neurochemical Research - March 19, 2024 Category: Neuroscience Authors: Evgenii D Kryl'skii Grigorii A Razuvaev Tatyana N Popova Sergei A Oleinik Svetlana M Medvedeva Khidmet S Shikhaliev Source Type: research
6-Hydroxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline Demonstrates Neuroprotective Properties in Experimental Parkinson's Disease by Enhancing the Antioxidant System, Normalising Chaperone Activity and Suppressing Apoptosis
Neurochem Res. 2024 Mar 19. doi: 10.1007/s11064-024-04125-9. Online ahead of print.ABSTRACTParkinson's disease (PD) is a neurodegenerative disease, whereby disturbances within the antioxidant defence system, increased aggregation of proteins, and activation of neuronal apoptosis all have a crucial role in the pathogenesis. In this context, exploring the neuroprotective capabilities of compounds that sustain the effectiveness of cellular defence systems in neurodegenerative disorders is worthwhile. During this study, we assessed how 6-hydroxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline (HTHQ), which has antioxidant properti...
Source: Neurochemical Research - March 19, 2024 Category: Neuroscience Authors: Evgenii D Kryl'skii Grigorii A Razuvaev Tatyana N Popova Sergei A Oleinik Svetlana M Medvedeva Khidmet S Shikhaliev Source Type: research
Remimazolam Attenuates LPS-Derived Cognitive Dysfunction via Subdiaphragmatic Vagus Nerve Target α7nAChR-Mediated Nrf2/HO-1 Signal Pathway
In this study, Lipopolysaccharide (5 mg/kg, LPS) severely impaired Sprague-Dawley rats spatial learning ability, memory, and cognitive function. However, remimazolam treatment showed a protective effect on LPS-induced cognitive dysfunction. Remimazolam partly reversed LPS-induced splenomegaly, decreased serum cytokine expression, suppressed hippocampal M1 microglial activation, and mitigated oxidative stress injury and neuroinflammation. Electroacupuncture (EA) or PNU282987 treatment improved LPS-induced cognitive dysfunction and also significantly inhibited neuroinflammation and systemic inflammation. However, MLA, ML385,...
Source: Neurochemical Research - March 13, 2024 Category: Neuroscience Authors: Zhan Zhou Ying Yang Yi Wei Yubo Xie Source Type: research
Negligible In Vitro Recovery of Macromolecules from Microdialysis Using 100 kDa Probes and Dextran in Perfusion Fluid
Neurochem Res. 2024 Mar 13. doi: 10.1007/s11064-024-04119-7. Online ahead of print.ABSTRACTMicrodialysis is applied in neurointensive care to monitor cerebral glucose metabolism. If recoverable, macromolecules may also serve as biomarkers in brain disease and provide clues to their passage across the blood-brain barrier. Our study aimed to investigate the in vitro recovery of human micro- and macromolecules using microdialysis catheters and perfusion fluids approved for clinical use. In vitro microdialysis of a bulk solution containing physiological or supraphysiological concentrations of glucose, lactate, pyruvate, human ...
Source: Neurochemical Research - March 13, 2024 Category: Neuroscience Authors: Spille Dorothee G S ørensen L R Olsen J F Bastlund F Sotty D Belling M H Olsen T I Mathiesen K M øller F Larsen P Birkeland Source Type: research
Remimazolam Attenuates LPS-Derived Cognitive Dysfunction via Subdiaphragmatic Vagus Nerve Target α7nAChR-Mediated Nrf2/HO-1 Signal Pathway
In this study, Lipopolysaccharide (5 mg/kg, LPS) severely impaired Sprague-Dawley rats spatial learning ability, memory, and cognitive function. However, remimazolam treatment showed a protective effect on LPS-induced cognitive dysfunction. Remimazolam partly reversed LPS-induced splenomegaly, decreased serum cytokine expression, suppressed hippocampal M1 microglial activation, and mitigated oxidative stress injury and neuroinflammation. Electroacupuncture (EA) or PNU282987 treatment improved LPS-induced cognitive dysfunction and also significantly inhibited neuroinflammation and systemic inflammation. However, MLA, ML385,...
Source: Neurochemical Research - March 13, 2024 Category: Neuroscience Authors: Zhan Zhou Ying Yang Yi Wei Yubo Xie Source Type: research
Negligible In Vitro Recovery of Macromolecules from Microdialysis Using 100 kDa Probes and Dextran in Perfusion Fluid
Neurochem Res. 2024 Mar 13. doi: 10.1007/s11064-024-04119-7. Online ahead of print.ABSTRACTMicrodialysis is applied in neurointensive care to monitor cerebral glucose metabolism. If recoverable, macromolecules may also serve as biomarkers in brain disease and provide clues to their passage across the blood-brain barrier. Our study aimed to investigate the in vitro recovery of human micro- and macromolecules using microdialysis catheters and perfusion fluids approved for clinical use. In vitro microdialysis of a bulk solution containing physiological or supraphysiological concentrations of glucose, lactate, pyruvate, human ...
Source: Neurochemical Research - March 13, 2024 Category: Neuroscience Authors: Spille Dorothee G S ørensen L R Olsen J F Bastlund F Sotty D Belling M H Olsen T I Mathiesen K M øller F Larsen P Birkeland Source Type: research
Remimazolam Attenuates LPS-Derived Cognitive Dysfunction via Subdiaphragmatic Vagus Nerve Target α7nAChR-Mediated Nrf2/HO-1 Signal Pathway
In this study, Lipopolysaccharide (5 mg/kg, LPS) severely impaired Sprague-Dawley rats spatial learning ability, memory, and cognitive function. However, remimazolam treatment showed a protective effect on LPS-induced cognitive dysfunction. Remimazolam partly reversed LPS-induced splenomegaly, decreased serum cytokine expression, suppressed hippocampal M1 microglial activation, and mitigated oxidative stress injury and neuroinflammation. Electroacupuncture (EA) or PNU282987 treatment improved LPS-induced cognitive dysfunction and also significantly inhibited neuroinflammation and systemic inflammation. However, MLA, ML385,...
Source: Neurochemical Research - March 13, 2024 Category: Neuroscience Authors: Zhan Zhou Ying Yang Yi Wei Yubo Xie Source Type: research
Negligible In Vitro Recovery of Macromolecules from Microdialysis Using 100 kDa Probes and Dextran in Perfusion Fluid
Neurochem Res. 2024 Mar 13. doi: 10.1007/s11064-024-04119-7. Online ahead of print.ABSTRACTMicrodialysis is applied in neurointensive care to monitor cerebral glucose metabolism. If recoverable, macromolecules may also serve as biomarkers in brain disease and provide clues to their passage across the blood-brain barrier. Our study aimed to investigate the in vitro recovery of human micro- and macromolecules using microdialysis catheters and perfusion fluids approved for clinical use. In vitro microdialysis of a bulk solution containing physiological or supraphysiological concentrations of glucose, lactate, pyruvate, human ...
Source: Neurochemical Research - March 13, 2024 Category: Neuroscience Authors: Spille Dorothee G S ørensen L R Olsen J F Bastlund F Sotty D Belling M H Olsen T I Mathiesen K M øller F Larsen P Birkeland Source Type: research
Remimazolam Attenuates LPS-Derived Cognitive Dysfunction via Subdiaphragmatic Vagus Nerve Target α7nAChR-Mediated Nrf2/HO-1 Signal Pathway
In this study, Lipopolysaccharide (5 mg/kg, LPS) severely impaired Sprague-Dawley rats spatial learning ability, memory, and cognitive function. However, remimazolam treatment showed a protective effect on LPS-induced cognitive dysfunction. Remimazolam partly reversed LPS-induced splenomegaly, decreased serum cytokine expression, suppressed hippocampal M1 microglial activation, and mitigated oxidative stress injury and neuroinflammation. Electroacupuncture (EA) or PNU282987 treatment improved LPS-induced cognitive dysfunction and also significantly inhibited neuroinflammation and systemic inflammation. However, MLA, ML385,...
Source: Neurochemical Research - March 13, 2024 Category: Neuroscience Authors: Zhan Zhou Ying Yang Yi Wei Yubo Xie Source Type: research
Negligible In Vitro Recovery of Macromolecules from Microdialysis Using 100 kDa Probes and Dextran in Perfusion Fluid
Neurochem Res. 2024 Mar 13. doi: 10.1007/s11064-024-04119-7. Online ahead of print.ABSTRACTMicrodialysis is applied in neurointensive care to monitor cerebral glucose metabolism. If recoverable, macromolecules may also serve as biomarkers in brain disease and provide clues to their passage across the blood-brain barrier. Our study aimed to investigate the in vitro recovery of human micro- and macromolecules using microdialysis catheters and perfusion fluids approved for clinical use. In vitro microdialysis of a bulk solution containing physiological or supraphysiological concentrations of glucose, lactate, pyruvate, human ...
Source: Neurochemical Research - March 13, 2024 Category: Neuroscience Authors: Spille Dorothee G S ørensen L R Olsen J F Bastlund F Sotty D Belling M H Olsen T I Mathiesen K M øller F Larsen P Birkeland Source Type: research
Remimazolam Attenuates LPS-Derived Cognitive Dysfunction via Subdiaphragmatic Vagus Nerve Target α7nAChR-Mediated Nrf2/HO-1 Signal Pathway
In this study, Lipopolysaccharide (5 mg/kg, LPS) severely impaired Sprague-Dawley rats spatial learning ability, memory, and cognitive function. However, remimazolam treatment showed a protective effect on LPS-induced cognitive dysfunction. Remimazolam partly reversed LPS-induced splenomegaly, decreased serum cytokine expression, suppressed hippocampal M1 microglial activation, and mitigated oxidative stress injury and neuroinflammation. Electroacupuncture (EA) or PNU282987 treatment improved LPS-induced cognitive dysfunction and also significantly inhibited neuroinflammation and systemic inflammation. However, MLA, ML385,...
Source: Neurochemical Research - March 13, 2024 Category: Neuroscience Authors: Zhan Zhou Ying Yang Yi Wei Yubo Xie Source Type: research
Negligible In Vitro Recovery of Macromolecules from Microdialysis Using 100 kDa Probes and Dextran in Perfusion Fluid
Neurochem Res. 2024 Mar 13. doi: 10.1007/s11064-024-04119-7. Online ahead of print.ABSTRACTMicrodialysis is applied in neurointensive care to monitor cerebral glucose metabolism. If recoverable, macromolecules may also serve as biomarkers in brain disease and provide clues to their passage across the blood-brain barrier. Our study aimed to investigate the in vitro recovery of human micro- and macromolecules using microdialysis catheters and perfusion fluids approved for clinical use. In vitro microdialysis of a bulk solution containing physiological or supraphysiological concentrations of glucose, lactate, pyruvate, human ...
Source: Neurochemical Research - March 13, 2024 Category: Neuroscience Authors: Spille Dorothee G S ørensen L R Olsen J F Bastlund F Sotty D Belling M H Olsen T I Mathiesen K M øller F Larsen P Birkeland Source Type: research
