Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia
Neurochem Res. 2023 Nov 28. doi: 10.1007/s11064-023-04057-w. Online ahead of print.ABSTRACTWhite matter dysplasia (WMD) in preterm infants due to intrauterine inflammation is caused by excessive apoptosis of oligodendrocyte precursor cells (OPCs). In recent years, studies have found that excessive autophagy and apoptosis are highly interconnected and important in infection and inflammatory diseases in general. Therefore, in this study, we aimed to confirm whether regulation of autophagy by using the Akt phosphorylation agonist SC79 can inhibit abnormal apoptosis of OPCs and promote myelin maturation and white matter develo...
Source: Neurochemical Research - November 28, 2023 Category: Neuroscience Authors: Zhongni Li Feng Zhang Li Huang Jiehong Deng Yutong Pan Ting Xu Jingyi Liu Na Gao Rongrong Duan Chunyan Shao Chan Wu Minrong Wang Liqun Lu Source Type: research

Pathogenesis of Depression in Alzheimer's Disease
Neurochem Res. 2023 Nov 28. doi: 10.1007/s11064-023-04061-0. Online ahead of print.ABSTRACTDepression is a prevalent occurrence among Alzheimer's disease (AD) patients, yet its underlying mechanism remains unclear. Recent investigations have revealed that several pathophysiological changes associated with Alzheimer's disease can lead to mood disorders. These alterations include irregularities in monoamine neurotransmitters, disruptions in glutamatergic synaptic transmission, neuro-inflammation, dysfunction within the hypothalamic-pituitary-adrenocortical (HPA) axis, diminished levels of brain-derived neurotrophic factor (B...
Source: Neurochemical Research - November 28, 2023 Category: Neuroscience Authors: Qingyang Zhan Fanyi Kong Shuai Shao Bo Zhang Shuming Huang Source Type: research

Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy
Neurochem Res. 2023 Nov 29. doi: 10.1007/s11064-023-04058-9. Online ahead of print.ABSTRACTIn the spinal cord, attenuation of the inhibitory action of glycine is related to an increase in both inflammatory and diabetic neuropathic pain; however, the glycine receptor involvement in diabetic neuropathy has not been reported. We determined the expression of the glycine receptor subunits (α1-α3 and β) in streptozotocin-induced diabetic Long-Evans rats by qPCR and Western blot. The total mRNA and protein expression (whole spinal cord homogenate) of the α1, α3, and β subunits did not change during diabetes; however, the α...
Source: Neurochemical Research - November 28, 2023 Category: Neuroscience Authors: Miguel Ángel Velázquez-Flores Gustavo S ánchez-Chávez Sara L Morales-L ázaro Ruth Ruiz Esparza-Garrido Alejandro Canizales-Ontiveros Roc ío Salceda Source Type: research

Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia
Neurochem Res. 2023 Nov 28. doi: 10.1007/s11064-023-04057-w. Online ahead of print.ABSTRACTWhite matter dysplasia (WMD) in preterm infants due to intrauterine inflammation is caused by excessive apoptosis of oligodendrocyte precursor cells (OPCs). In recent years, studies have found that excessive autophagy and apoptosis are highly interconnected and important in infection and inflammatory diseases in general. Therefore, in this study, we aimed to confirm whether regulation of autophagy by using the Akt phosphorylation agonist SC79 can inhibit abnormal apoptosis of OPCs and promote myelin maturation and white matter develo...
Source: Neurochemical Research - November 28, 2023 Category: Neuroscience Authors: Zhongni Li Feng Zhang Li Huang Jiehong Deng Yutong Pan Ting Xu Jingyi Liu Na Gao Rongrong Duan Chunyan Shao Chan Wu Minrong Wang Liqun Lu Source Type: research

Pathogenesis of Depression in Alzheimer's Disease
Neurochem Res. 2023 Nov 28. doi: 10.1007/s11064-023-04061-0. Online ahead of print.ABSTRACTDepression is a prevalent occurrence among Alzheimer's disease (AD) patients, yet its underlying mechanism remains unclear. Recent investigations have revealed that several pathophysiological changes associated with Alzheimer's disease can lead to mood disorders. These alterations include irregularities in monoamine neurotransmitters, disruptions in glutamatergic synaptic transmission, neuro-inflammation, dysfunction within the hypothalamic-pituitary-adrenocortical (HPA) axis, diminished levels of brain-derived neurotrophic factor (B...
Source: Neurochemical Research - November 28, 2023 Category: Neuroscience Authors: Qingyang Zhan Fanyi Kong Shuai Shao Bo Zhang Shuming Huang Source Type: research

Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy
Neurochem Res. 2023 Nov 29. doi: 10.1007/s11064-023-04058-9. Online ahead of print.ABSTRACTIn the spinal cord, attenuation of the inhibitory action of glycine is related to an increase in both inflammatory and diabetic neuropathic pain; however, the glycine receptor involvement in diabetic neuropathy has not been reported. We determined the expression of the glycine receptor subunits (α1-α3 and β) in streptozotocin-induced diabetic Long-Evans rats by qPCR and Western blot. The total mRNA and protein expression (whole spinal cord homogenate) of the α1, α3, and β subunits did not change during diabetes; however, the α...
Source: Neurochemical Research - November 28, 2023 Category: Neuroscience Authors: Miguel Ángel Velázquez-Flores Gustavo S ánchez-Chávez Sara L Morales-L ázaro Ruth Ruiz Esparza-Garrido Alejandro Canizales-Ontiveros Roc ío Salceda Source Type: research

Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia
Neurochem Res. 2023 Nov 28. doi: 10.1007/s11064-023-04057-w. Online ahead of print.ABSTRACTWhite matter dysplasia (WMD) in preterm infants due to intrauterine inflammation is caused by excessive apoptosis of oligodendrocyte precursor cells (OPCs). In recent years, studies have found that excessive autophagy and apoptosis are highly interconnected and important in infection and inflammatory diseases in general. Therefore, in this study, we aimed to confirm whether regulation of autophagy by using the Akt phosphorylation agonist SC79 can inhibit abnormal apoptosis of OPCs and promote myelin maturation and white matter develo...
Source: Neurochemical Research - November 28, 2023 Category: Neuroscience Authors: Zhongni Li Feng Zhang Li Huang Jiehong Deng Yutong Pan Ting Xu Jingyi Liu Na Gao Rongrong Duan Chunyan Shao Chan Wu Minrong Wang Liqun Lu Source Type: research

Pathogenesis of Depression in Alzheimer's Disease
Neurochem Res. 2023 Nov 28. doi: 10.1007/s11064-023-04061-0. Online ahead of print.ABSTRACTDepression is a prevalent occurrence among Alzheimer's disease (AD) patients, yet its underlying mechanism remains unclear. Recent investigations have revealed that several pathophysiological changes associated with Alzheimer's disease can lead to mood disorders. These alterations include irregularities in monoamine neurotransmitters, disruptions in glutamatergic synaptic transmission, neuro-inflammation, dysfunction within the hypothalamic-pituitary-adrenocortical (HPA) axis, diminished levels of brain-derived neurotrophic factor (B...
Source: Neurochemical Research - November 28, 2023 Category: Neuroscience Authors: Qingyang Zhan Fanyi Kong Shuai Shao Bo Zhang Shuming Huang Source Type: research

Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy
Neurochem Res. 2023 Nov 29. doi: 10.1007/s11064-023-04058-9. Online ahead of print.ABSTRACTIn the spinal cord, attenuation of the inhibitory action of glycine is related to an increase in both inflammatory and diabetic neuropathic pain; however, the glycine receptor involvement in diabetic neuropathy has not been reported. We determined the expression of the glycine receptor subunits (α1-α3 and β) in streptozotocin-induced diabetic Long-Evans rats by qPCR and Western blot. The total mRNA and protein expression (whole spinal cord homogenate) of the α1, α3, and β subunits did not change during diabetes; however, the α...
Source: Neurochemical Research - November 28, 2023 Category: Neuroscience Authors: Miguel Ángel Velázquez-Flores Gustavo S ánchez-Chávez Sara L Morales-L ázaro Ruth Ruiz Esparza-Garrido Alejandro Canizales-Ontiveros Roc ío Salceda Source Type: research

Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia
Neurochem Res. 2023 Nov 28. doi: 10.1007/s11064-023-04057-w. Online ahead of print.ABSTRACTWhite matter dysplasia (WMD) in preterm infants due to intrauterine inflammation is caused by excessive apoptosis of oligodendrocyte precursor cells (OPCs). In recent years, studies have found that excessive autophagy and apoptosis are highly interconnected and important in infection and inflammatory diseases in general. Therefore, in this study, we aimed to confirm whether regulation of autophagy by using the Akt phosphorylation agonist SC79 can inhibit abnormal apoptosis of OPCs and promote myelin maturation and white matter develo...
Source: Neurochemical Research - November 28, 2023 Category: Neuroscience Authors: Zhongni Li Feng Zhang Li Huang Jiehong Deng Yutong Pan Ting Xu Jingyi Liu Na Gao Rongrong Duan Chunyan Shao Chan Wu Minrong Wang Liqun Lu Source Type: research

Pathogenesis of Depression in Alzheimer's Disease
Neurochem Res. 2023 Nov 28. doi: 10.1007/s11064-023-04061-0. Online ahead of print.ABSTRACTDepression is a prevalent occurrence among Alzheimer's disease (AD) patients, yet its underlying mechanism remains unclear. Recent investigations have revealed that several pathophysiological changes associated with Alzheimer's disease can lead to mood disorders. These alterations include irregularities in monoamine neurotransmitters, disruptions in glutamatergic synaptic transmission, neuro-inflammation, dysfunction within the hypothalamic-pituitary-adrenocortical (HPA) axis, diminished levels of brain-derived neurotrophic factor (B...
Source: Neurochemical Research - November 28, 2023 Category: Neuroscience Authors: Qingyang Zhan Fanyi Kong Shuai Shao Bo Zhang Shuming Huang Source Type: research

Hexavalent Chromium Induces Neurotoxicity by Triggering Mitochondrial Dysfunction and ROS-Mediated Signals
Neurochem Res. 2023 Nov 27. doi: 10.1007/s11064-023-04063-y. Online ahead of print.ABSTRACTHexavalent chromium (Cr (VI)), one of the most detrimental pollutants, has been ubiquitously present in the environment and causes serious toxicity to humans, such as hepatotoxicity, nephrotoxicity, pulmonary toxicity, and cardiotoxicity. However, Cr (VI)-induced neurotoxicity in primary neuron level has not been well explored yet. Herein, potassium dichromate (K2Cr2O7) was employed to examine the neurotoxicity of Cr (VI) in rat primary hippocampal neurons. MTT test was used to examine the neural viability. Mitochondrial dysfunction ...
Source: Neurochemical Research - November 27, 2023 Category: Neuroscience Authors: Tongtong Zhang Lina Feng Jie Cui Weiwei Tong Han Zhao Tingchao Wu Pu Zhang Xianjun Wang Yingjun Gao Jing Su Xiaoyan Fu Source Type: research

Nutritional Support of Crocin on Neurobehavioral Disabilities Induced by Cisplatin-Based Chemotherapy in Rats
In conclusion, since free radicals produced by cisplatin are a contributing factor to memory loss and movement disorders, crocin, owing to its antioxidant properties, improved passive avoidance learning as well as motor activity.PMID:38010604 | DOI:10.1007/s11064-023-04059-8 (Source: Neurochemical Research)
Source: Neurochemical Research - November 27, 2023 Category: Neuroscience Authors: Zohreh Ghotbeddin Mohsen Peysokhan Anahita Memar Dezfouli Mohammad Asadi Iraee Source Type: research

The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy
In conclusion, there is a strong controversy concerning the potential role of BDNF in epilepsy. Therefore, preclinical, molecular, and clinical studies are warranted in this regard.PMID:38006577 | DOI:10.1007/s11064-023-04064-x (Source: Neurochemical Research)
Source: Neurochemical Research - November 25, 2023 Category: Neuroscience Authors: Raed AlRuwaili Hayder M Al-Kuraishy Ali I Al-Gareeb Naif H Ali Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research

The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy
In conclusion, there is a strong controversy concerning the potential role of BDNF in epilepsy. Therefore, preclinical, molecular, and clinical studies are warranted in this regard.PMID:38006577 | DOI:10.1007/s11064-023-04064-x (Source: Neurochemical Research)
Source: Neurochemical Research - November 25, 2023 Category: Neuroscience Authors: Raed AlRuwaili Hayder M Al-Kuraishy Ali I Al-Gareeb Naif H Ali Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research