Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats
Neurochem Res. 2024 Feb 18. doi: 10.1007/s11064-024-04117-9. Online ahead of print.ABSTRACTSocial isolation is a state of lack of social connections, involving the modulation of different molecular signalling cascades and associated with high risk of mental health issues. To investigate if and how gene expression is modulated by social experience at the central level, we analyzed the effects of 5 weeks of social isolation in rats focusing on endocannabinoid system genes transcription in key brain regions involved in emotional control. We observed selective reduction in mRNA levels for fatty acid amide hydrolase (Faah) and ...
Source: Neurochemical Research - February 18, 2024 Category: Neuroscience Authors: Antonio Girella Martina Di Bartolomeo Enrico Dainese Valeria Buzzelli Viviana Trezza Claudio D'Addario Source Type: research
Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats
Neurochem Res. 2024 Feb 18. doi: 10.1007/s11064-024-04117-9. Online ahead of print.ABSTRACTSocial isolation is a state of lack of social connections, involving the modulation of different molecular signalling cascades and associated with high risk of mental health issues. To investigate if and how gene expression is modulated by social experience at the central level, we analyzed the effects of 5 weeks of social isolation in rats focusing on endocannabinoid system genes transcription in key brain regions involved in emotional control. We observed selective reduction in mRNA levels for fatty acid amide hydrolase (Faah) and ...
Source: Neurochemical Research - February 18, 2024 Category: Neuroscience Authors: Antonio Girella Martina Di Bartolomeo Enrico Dainese Valeria Buzzelli Viviana Trezza Claudio D'Addario Source Type: research
Effect of CTLA-4 Inhibition on Inflammation and Apoptosis After Spinal Cord Injury
This study aimed to investigate the influence of CTLA-4 on SCI. A weight-drop technique was used to establish a rat model of SCI. To examine the safeguarding effect of CTLA-4 on the restoration of motor function in rats with SCI, the Basso-Beattie-Bresnahan (BBB) scale and inclined plane test were employed to assess locomotion. Neuronal degeneration and apoptosis were assessed using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL) and Fluoro-Jade B labeling, respectively, and the activity of microglial cells was examined by immunofluorescence. To evaluate the impact of CTLA4 on SCI, the levels...
Source: Neurochemical Research - February 17, 2024 Category: Neuroscience Authors: Wei Mao Feng Jiang Chunping Zhu Jun Liu Zhao Lu Yinwei Qian Jinchun Xiao Source Type: research
Effect of CTLA-4 Inhibition on Inflammation and Apoptosis After Spinal Cord Injury
This study aimed to investigate the influence of CTLA-4 on SCI. A weight-drop technique was used to establish a rat model of SCI. To examine the safeguarding effect of CTLA-4 on the restoration of motor function in rats with SCI, the Basso-Beattie-Bresnahan (BBB) scale and inclined plane test were employed to assess locomotion. Neuronal degeneration and apoptosis were assessed using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL) and Fluoro-Jade B labeling, respectively, and the activity of microglial cells was examined by immunofluorescence. To evaluate the impact of CTLA4 on SCI, the levels...
Source: Neurochemical Research - February 17, 2024 Category: Neuroscience Authors: Wei Mao Feng Jiang Chunping Zhu Jun Liu Zhao Lu Yinwei Qian Jinchun Xiao Source Type: research
Egg White Hydrolysate Mitigates Cadmium-induced Neurological Disorders and Oxidative Damage
Neurochem Res. 2024 Feb 14. doi: 10.1007/s11064-024-04110-2. Online ahead of print.ABSTRACTWe aimed to investigate whether the consumption of Egg White Hydrolysate (EWH) acts on nervous system disorders induced by exposure to Cadmium (Cd) in rats. Male Wistar rats were divided into (a) Control (Ct): H2O by gavage for 28 days + H2O (i.p. - 15th - 28th day); (b) Cadmium (Cd): H2O by gavage + CdCl2 - 1 mg/kg/day (i.p. - 15th - 28th day); (c) EWH 14d: EWH 1 g/kg/day by gavage for 14 days + H2O (i.p.- 15th - 28th day); (d) Cd + EWH cotreatment (Cd + EWHco): CdCl2 + EWH for 14 days; (e) EWH 28d: EWH for 28 days; (f) EWHpre + Cd:...
Source: Neurochemical Research - February 14, 2024 Category: Neuroscience Authors: Jos é Eudes Gomes Pinheiro Júnior Priscila Marques Sosa Ben-Hur Souto das Neves Dalton Valentim Vassallo Franck Maciel Pe çanha Marta Miguel-Castro P âmela Billig Mello-Carpes Giulia Alessandra Wiggers Source Type: research
Epidermal Growth Factor Suppresses the Development of GABAergic Neurons Via the Modulation of Perineuronal Net Formation in the Neocortex of Developing Rodent Brains
We examined the effect of EGF on CSPG production and PNN formation as a potential molecular mechanism for the inhibition of inhibiting GABAergic neuronal development by EGF. In EGF-overexpressing transgenic (EGF-Tg) mice, the number of PNN-positive PV neurons was decreased in the cortex compared with that in wild-type mice, as in our previous report. The amount of CS and neurocan was also lower in the cortex of EGF-Tg mice, with a similar decrease observed in EGF-treated cultured cortical neurons. PD153035, an EGF receptor (ErbB1) kinase inhibitor, prevented those mentioned above excess EGF-induced reduction in PNN. We exp...
Source: Neurochemical Research - February 14, 2024 Category: Neuroscience Authors: Yuriko Iwakura Yutaro Kobayashi Hisaaki Namba Hiroyuki Nawa Nobuyuki Takei Source Type: research
Egg White Hydrolysate Mitigates Cadmium-induced Neurological Disorders and Oxidative Damage
Neurochem Res. 2024 Feb 14. doi: 10.1007/s11064-024-04110-2. Online ahead of print.ABSTRACTWe aimed to investigate whether the consumption of Egg White Hydrolysate (EWH) acts on nervous system disorders induced by exposure to Cadmium (Cd) in rats. Male Wistar rats were divided into (a) Control (Ct): H2O by gavage for 28 days + H2O (i.p. - 15th - 28th day); (b) Cadmium (Cd): H2O by gavage + CdCl2 - 1 mg/kg/day (i.p. - 15th - 28th day); (c) EWH 14d: EWH 1 g/kg/day by gavage for 14 days + H2O (i.p.- 15th - 28th day); (d) Cd + EWH cotreatment (Cd + EWHco): CdCl2 + EWH for 14 days; (e) EWH 28d: EWH for 28 days; (f) EWHpre + Cd:...
Source: Neurochemical Research - February 14, 2024 Category: Neuroscience Authors: Jos é Eudes Gomes Pinheiro Júnior Priscila Marques Sosa Ben-Hur Souto das Neves Dalton Valentim Vassallo Franck Maciel Pe çanha Marta Miguel-Castro P âmela Billig Mello-Carpes Giulia Alessandra Wiggers Source Type: research
Epidermal Growth Factor Suppresses the Development of GABAergic Neurons Via the Modulation of Perineuronal Net Formation in the Neocortex of Developing Rodent Brains
We examined the effect of EGF on CSPG production and PNN formation as a potential molecular mechanism for the inhibition of inhibiting GABAergic neuronal development by EGF. In EGF-overexpressing transgenic (EGF-Tg) mice, the number of PNN-positive PV neurons was decreased in the cortex compared with that in wild-type mice, as in our previous report. The amount of CS and neurocan was also lower in the cortex of EGF-Tg mice, with a similar decrease observed in EGF-treated cultured cortical neurons. PD153035, an EGF receptor (ErbB1) kinase inhibitor, prevented those mentioned above excess EGF-induced reduction in PNN. We exp...
Source: Neurochemical Research - February 14, 2024 Category: Neuroscience Authors: Yuriko Iwakura Yutaro Kobayashi Hisaaki Namba Hiroyuki Nawa Nobuyuki Takei Source Type: research
Exogenous Substrates Prevent the Decline in the Cellular ATP Content of Primary Rat Astrocytes During Glucose Deprivation
Neurochem Res. 2024 Feb 11. doi: 10.1007/s11064-024-04104-0. Online ahead of print.ABSTRACTBrain astrocytes are well known for their broad metabolic potential. After glucose deprivation, cultured primary astrocytes maintain a high cellular ATP content for many hours by mobilizing endogenous substrates, but within 24 h the specific cellular ATP content was lowered to around 30% of the initial ATP content. This experimental setting was used to test for the potential of various exogenous substrates to prevent a loss in cellular ATP in glucose deprived astrocytes. The presence of various extracellular monocarboxylates, purine ...
Source: Neurochemical Research - February 11, 2024 Category: Neuroscience Authors: Antonia Regina Harders Paul Spellerberg Ralf Dringen Source Type: research
Electroacupuncture Alleviates Pain by Suppressing P2Y12R-Dependent Microglial Activation in Monoarthritic Rats
Neurochem Res. 2024 Feb 10. doi: 10.1007/s11064-024-04114-y. Online ahead of print.ABSTRACTElectroacupuncture (EA) effectively improves arthritis-induced hyperalgesia and allodynia by repressing spinal microglial activation, which plays a crucial role in pain hypersensitivity following tissue inflammation. However, the mechanism by which EA suppresses spinal microglial activation in monoarthritis (MA) remains unclear. In the present study, a rat model of MA was established through unilateral ankle intra-articular injection of complete Freund's adjuvant (CFA). The relationship among P2Y12 receptor (P2Y12R) expression, spina...
Source: Neurochemical Research - February 10, 2024 Category: Neuroscience Authors: Jing Wang Wei Song Yujiao Zhang Jian Wang Yongqiang Wang Jiangang Song Yalan Zhou Source Type: research
A Review of Cerebrospinal Fluid Circulation and the Pathogenesis of Congenital Hydrocephalus
Neurochem Res. 2024 Feb 10. doi: 10.1007/s11064-024-04113-z. Online ahead of print.ABSTRACTThe brain's ventricles are filled with a colorless fluid known as cerebrospinal fluid (CSF). When there is an excessive accumulation of CSF in the ventricles, it can result in high intracranial pressure, ventricular enlargement, and compression of the surrounding brain tissue, leading to potential damage. This condition is referred to as hydrocephalus. Hydrocephalus is classified into two categories: congenital and acquired. Congenital hydrocephalus (CH) poses significant challenges for affected children and their families, particula...
Source: Neurochemical Research - February 10, 2024 Category: Neuroscience Authors: Mingzhao Zhang Xiangjun Hu Lifeng Wang Source Type: research
Pretreatment with Liposome-Encapsulated Shrimp Shell Extract Attenuated Neuronal Damage and Death in A β < sub > 1-42 < /sub > -Induced Memory Deficits in Rats
Neurochem Res. 2024 Feb 7. doi: 10.1007/s11064-024-04103-1. Online ahead of print.ABSTRACTThe accumulation of amyloid-beta (Aβ) peptides is a crucial factor in the neuronal degeneration of Alzheimer's disease (AD). The current study investigated the underlying neuroprotective mechanisms of shrimp shell extract (SSE) and liposome-encapsulated SSE (SSE/L) against Aβ1-42-induced neuronal damage and death in rats. Intracerebroventricular infusion of Aβ1-42 effectively induced memory decline, as observed in a reduction of the rat's discriminating ability in the novel object recognition and novel object location tasks. Oral p...
Source: Neurochemical Research - February 7, 2024 Category: Neuroscience Authors: Zulkiflee Kuedo Thunwa Binlateh Soottawat Benjakul Pilaiwanwadee Hutamekalin Source Type: research
Sulphated Fucooligosaccharide from Sargassum Horneri: Structural Analysis and Anti-Alzheimer Activity
Neurochem Res. 2024 Feb 2. doi: 10.1007/s11064-024-04107-x. Online ahead of print.ABSTRACTIn the present study, sulfated polysaccharides were obtained by digestion of Sargassum horneri and preparation with enzyme-assisted extraction using three food-grade enzymes, and their anti- Alzheimer's activities were investigated. The results demonstrated that the crude sulfated polysaccharides extracted using AMGSP, CSP and VSP dose-dependently (25-100 µg·mL- 1) raised the spontaneous alternating manner (%) in the Y maze experiment of mice and reduced the escape latency time in Morris maze test. AMGSP, CSP and VSP also exhibited ...
Source: Neurochemical Research - February 2, 2024 Category: Neuroscience Authors: Ling-Jian Zhang Hao-Zheng Zhang Ya-Wen Liu Min Tang Yong-Jun Jiang Fu-Nan Li Li-Ping Guan Qing-Hao Jin Source Type: research
7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia
Neurochem Res. 2024 Feb 1. doi: 10.1007/s11064-023-04090-9. Online ahead of print.ABSTRACTVascular dementia (VD) is a degenerative cerebrovascular disorder associated with progressive cognitive decline. Previous reports have shown that 7,8-dihydroxyflavone (7,8-DHF), a well-known TrkB agonist, effectively ameliorates cognitive deficits in several disease models. Therefore, this study investigated the protective effects of 7,8-DHF against 2-VO-induced VD. VD was established in rats using the permanent bilateral carotid arteries occlusion (two-vessel occlusion, 2-VO) model. 7,8-DHF (5, 10, and 20 mg/kg) and Donepezil (10 mg/...
Source: Neurochemical Research - February 1, 2024 Category: Neuroscience Authors: Navneet Dhaliwal Jatinder Dhaliwal Kanwaljit Chopra Source Type: research
The Progress of Poststroke Seizures
This article briefly presents the current definition, risk factors, pathogenesis, and prognosis of poststroke seizures based on reported studies and literature reviews, aiming to enrich the available knowledge of this disease.PMID:38294644 | DOI:10.1007/s11064-023-04079-4 (Source: Neurochemical Research)
Source: Neurochemical Research - January 31, 2024 Category: Neuroscience Authors: Cong Xie Wei Zhao Xu Zhang Ju Liu Jinzhi Liu Zhangyong Xia Source Type: research
