Non-coding RNAs and Aquaporin 4: Their Role in the Pathogenesis of Neurological Disorders
Neurochem Res. 2023 Dec 19. doi: 10.1007/s11064-023-04067-8. Online ahead of print.ABSTRACTNeurological disorders are a major group of non-communicable diseases affecting quality of life. Non-Coding RNAs (ncRNAs) have an important role in the etiology of neurological disorders. In studies on the genesis of neurological diseases, aquaporin 4 (AQP4) expression and activity have both been linked to ncRNAs. The upregulation or downregulation of several ncRNAs leads to neurological disorder progression by targeting AQP4. The role of ncRNAs and AQP4 in neurological disorders is discussed in this review.PMID:38114727 | DOI:10.100...
Source: Neurochemical Research - December 19, 2023 Category: Neuroscience Authors: Zahra Yaghoobi Shahrzad Sadat Seyed Bagher Nazeri Amir Asadi Ehsan Derafsh Abdolkarim Talebi Taheri Zeinab Tamtaji Ehsan Dadgostar Fatemeh Rahmati-Dehkordi Michael Aschner Hamed Mirzaei Omid Reza Tamtaji Fatemeh Nabavizadeh Source Type: research
Transcranial Irradiation Mitigates Paradoxical Sleep Deprivation Effect in an Age-Dependent Manner: Role of BDNF and GLP-1
In conclusion, NIR PBM seems to promote cellular longevity of senile hippocampal cells by combating ROS, elevating neurotrophic factors, thus improving cognitive performance. The present findings provide NIR as a possible candidate for hippocampal neuronal insults accompanying aging and SD.PMID:38114728 | DOI:10.1007/s11064-023-04071-y (Source: Neurochemical Research)
Source: Neurochemical Research - December 19, 2023 Category: Neuroscience Authors: Radwa H Lutfy Amina E Essawy Haitham S Mohammed Marwa M Shakweer Sherine Abdel Salam Source Type: research
Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4
Neurochem Res. 2023 Dec 19. doi: 10.1007/s11064-023-04075-8. Online ahead of print.ABSTRACTTherapeutic hypothermia (TH) provides neuroprotection. However, the cellular mechanisms underlying the neuroprotective effects of TH are not fully elucidated. Regulation of microglial activation has the potential to treat a variety of nervous system diseases. Transient receptor potential vanilloid 4 (TRPV4), a nonselective cation channel, is activated by temperature stimulus at 27-35 °C. Although it is speculated that TRPV4 is associated with the neuroprotective mechanisms of TH, the role of TRPV4 in the neuroprotective effects of T...
Source: Neurochemical Research - December 19, 2023 Category: Neuroscience Authors: Naoya Fukuda Kohki Toriuchi Rina Mimoto Hiromasa Aoki Hiroki Kakita Yoshiaki Suzuki Satoru Takeshita Tetsuya Tamura Hisao Yamamura Yasumichi Inoue Hidetoshi Hayashi Yasumasa Yamada Mineyoshi Aoyama Source Type: research
Relationship of Sleep Disorder with Neurodegenerative and Psychiatric Diseases: An Updated Review
Neurochem Res. 2023 Dec 18. doi: 10.1007/s11064-023-04086-5. Online ahead of print.ABSTRACTSleep disorders affect many people worldwide and can accompany neurodegenerative and psychiatric diseases. Sleep may be altered before the clinical manifestations of some of these diseases appear. Moreover, some sleep disorders affect the physiological organization and function of the brain by influencing gene expression, accelerating the accumulation of abnormal proteins, interfering with the clearance of abnormal proteins, or altering the levels of related hormones and neurotransmitters, which can cause or may be associated with th...
Source: Neurochemical Research - December 18, 2023 Category: Neuroscience Authors: Xiao Xiao Yimin Rui Yu Jin Ming Chen Source Type: research
Relationship of Sleep Disorder with Neurodegenerative and Psychiatric Diseases: An Updated Review
Neurochem Res. 2023 Dec 18. doi: 10.1007/s11064-023-04086-5. Online ahead of print.ABSTRACTSleep disorders affect many people worldwide and can accompany neurodegenerative and psychiatric diseases. Sleep may be altered before the clinical manifestations of some of these diseases appear. Moreover, some sleep disorders affect the physiological organization and function of the brain by influencing gene expression, accelerating the accumulation of abnormal proteins, interfering with the clearance of abnormal proteins, or altering the levels of related hormones and neurotransmitters, which can cause or may be associated with th...
Source: Neurochemical Research - December 18, 2023 Category: Neuroscience Authors: Xiao Xiao Yimin Rui Yu Jin Ming Chen Source Type: research
Nitronyl Nitroxide Ameliorates Hypobaric Hypoxia-Induced Cognitive Impairment in Mice by Suppressing the Oxidative Stress, Inflammatory Response and Apoptosis
Neurochem Res. 2023 Dec 16. doi: 10.1007/s11064-023-04080-x. Online ahead of print.ABSTRACTAbundant investigations have shown that hypobaric hypoxia (HH) causes cognitive impairment, mostly attributed to oxidative stress, inflammation, and apoptosis. HPN (4'-hydroxyl-2-subsitiuted phenylnitronyl nitroxide) is an excellent free radical scavenger with anti-inflammatory and anti-apoptotic activities. Our previous study has found that HPN exhibited neuroprotective effect on HH induced brain injury. In the present study, we examined the protective effect and potential mechanism of HPN on HH-induced cognitive impairment. Male mi...
Source: Neurochemical Research - December 16, 2023 Category: Neuroscience Authors: Linlin Jing Qingyue Da Shuyu Zhang Jie Zhang Huiping Ma Hongbo Luo Source Type: research
Memantine Improves Memory and Neurochemical Damage in a Model of Maple Syrup Urine Disease
Neurochem Res. 2023 Dec 16. doi: 10.1007/s11064-023-04072-x. Online ahead of print.ABSTRACTMaple Syrup Urine Disease (MSUD) is a metabolic disease characterized by the accumulation of branched-chain amino acids (BCAA) in different tissues due to a deficit in the branched-chain alpha-ketoacid dehydrogenase complex. The most common symptoms are poor feeding, psychomotor delay, and neurological damage. However, dietary therapy is not effective. Studies have demonstrated that memantine improves neurological damage in neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Therefore, we hypothesize that memant...
Source: Neurochemical Research - December 16, 2023 Category: Neuroscience Authors: Isabela da Silva Lemos Carolina Antunes Torres Carolina Giassi Alano Rafaela Tezza Matiola Rejane de Figueiredo Seldenreich Alex Paulo Zeferino Padilha Ellen De Pieri Pauline Souza Effting Ricardo Andrez Machado-De- Ávila Gislaine Zilli R éus Guilhian L Source Type: research
Nitronyl Nitroxide Ameliorates Hypobaric Hypoxia-Induced Cognitive Impairment in Mice by Suppressing the Oxidative Stress, Inflammatory Response and Apoptosis
Neurochem Res. 2023 Dec 16. doi: 10.1007/s11064-023-04080-x. Online ahead of print.ABSTRACTAbundant investigations have shown that hypobaric hypoxia (HH) causes cognitive impairment, mostly attributed to oxidative stress, inflammation, and apoptosis. HPN (4'-hydroxyl-2-subsitiuted phenylnitronyl nitroxide) is an excellent free radical scavenger with anti-inflammatory and anti-apoptotic activities. Our previous study has found that HPN exhibited neuroprotective effect on HH induced brain injury. In the present study, we examined the protective effect and potential mechanism of HPN on HH-induced cognitive impairment. Male mi...
Source: Neurochemical Research - December 16, 2023 Category: Neuroscience Authors: Linlin Jing Qingyue Da Shuyu Zhang Jie Zhang Huiping Ma Hongbo Luo Source Type: research
The Impact of Dipyridamole on Disease-Associated Microglia Phenotypic Transformation in White Matter Lesions Induced by Chronic Cerebral Hypoperfusion
This study aimed to investigate whether dipyridamole could alleviate WMLs by regulating the phenotype of disease-associated microglia (DAM) through equilibrative nucleoside transporter 2 (ENT2) and adenosine A2A receptor (Adora2a) and to clarify the underlying molecular mechanisms. CCH rat models were constructed to mimic VaD. Morris water maze and Luxol Fast Blue staining were employed to assess cognitive function and quantify the severity of WMLs, respectively. Immunofluorescent staining was performed to analyze the activation of glial cells and the phenotypic transformation of DAM. Additionally, levels of ENT2, proteins...
Source: Neurochemical Research - December 15, 2023 Category: Neuroscience Authors: Wenchao Cheng Yuhan Wang Lan Zhang Chang Cheng Xiuying Chen Wen Huang Source Type: research
Lateral Habenula Neurons Signal Cold Aversion and Participate in Cold Aversion
In this study, we demonstrate an elevation in the population activity of LHb neurons following exposure to cold stimuli. Additionally, we establish the necessity of Vglut2-expressing neurons within the LHb for the encoding of cold aversion behaviors. Furthermore, we have elucidated a neural circuit from excitatory neurons of the dorsomedial hypothalamus (DMH) to LHb that plays a crucial role in this progress. Manipulation of the DMH-LHb circuit has a significant impact on cold aversion behavior in mice. It is worth noting that this circuit does not exhibit any noticeable effects on autonomic thermoregulation or depression-...
Source: Neurochemical Research - December 15, 2023 Category: Neuroscience Authors: Rui Liu Huan Xiang Chunyang Liu Qiuyi Jiang Yanchao Liang Guangzheng Wang Lu Wang Yi Sun Guang Yang Source Type: research
Multifaceted Neuroprotective Role of Punicalagin: A Review
Neurochem Res. 2023 Dec 12. doi: 10.1007/s11064-023-04081-w. Online ahead of print.ABSTRACTMillions of people worldwide are currently afflicted with neurologic conditions like a seizure, depression, stress, Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, the precise etiopathology of these diseases is still unknown. Substantial studies are being conducted to discover more treatments against these disorders because many patients do not experience the therapeutic benefits that would be expected from using existing pharmaceutical strategies. Herbal medicines which have been used in traditional medi...
Source: Neurochemical Research - December 12, 2023 Category: Neuroscience Authors: Nazia Siddiqui Alimuddin Saifi Anurag Chaudhary Prabhash Nath Tripathi Ankit Chaudhary Alok Sharma Source Type: research
Multifaceted Neuroprotective Role of Punicalagin: A Review
Neurochem Res. 2023 Dec 12. doi: 10.1007/s11064-023-04081-w. Online ahead of print.ABSTRACTMillions of people worldwide are currently afflicted with neurologic conditions like a seizure, depression, stress, Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, the precise etiopathology of these diseases is still unknown. Substantial studies are being conducted to discover more treatments against these disorders because many patients do not experience the therapeutic benefits that would be expected from using existing pharmaceutical strategies. Herbal medicines which have been used in traditional medi...
Source: Neurochemical Research - December 12, 2023 Category: Neuroscience Authors: Nazia Siddiqui Alimuddin Saifi Anurag Chaudhary Prabhash Nath Tripathi Ankit Chaudhary Alok Sharma Source Type: research
Multifaceted Neuroprotective Role of Punicalagin: A Review
Neurochem Res. 2023 Dec 12. doi: 10.1007/s11064-023-04081-w. Online ahead of print.ABSTRACTMillions of people worldwide are currently afflicted with neurologic conditions like a seizure, depression, stress, Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, the precise etiopathology of these diseases is still unknown. Substantial studies are being conducted to discover more treatments against these disorders because many patients do not experience the therapeutic benefits that would be expected from using existing pharmaceutical strategies. Herbal medicines which have been used in traditional medi...
Source: Neurochemical Research - December 12, 2023 Category: Neuroscience Authors: Nazia Siddiqui Alimuddin Saifi Anurag Chaudhary Prabhash Nath Tripathi Ankit Chaudhary Alok Sharma Source Type: research
Multifaceted Neuroprotective Role of Punicalagin: A Review
Neurochem Res. 2023 Dec 12. doi: 10.1007/s11064-023-04081-w. Online ahead of print.ABSTRACTMillions of people worldwide are currently afflicted with neurologic conditions like a seizure, depression, stress, Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, the precise etiopathology of these diseases is still unknown. Substantial studies are being conducted to discover more treatments against these disorders because many patients do not experience the therapeutic benefits that would be expected from using existing pharmaceutical strategies. Herbal medicines which have been used in traditional medi...
Source: Neurochemical Research - December 12, 2023 Category: Neuroscience Authors: Nazia Siddiqui Alimuddin Saifi Anurag Chaudhary Prabhash Nath Tripathi Ankit Chaudhary Alok Sharma Source Type: research
CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets
In conclusion, the significance of circRNA as a potential prognostic biomarker and a viable therapeutic target was underscored.PMID:38063946 | DOI:10.1007/s11064-023-04077-6 (Source: Neurochemical Research)
Source: Neurochemical Research - December 8, 2023 Category: Neuroscience Authors: Xiao-Ling Chen Quan-Dan Tan Ke-Jie Chen Dan-Ni Zheng Hong-Wei Deng Song He Feng-Kai Mao Jun-Li Hao Wei-Dong Le Jie Yang Source Type: research
