Kidney disease as a medical complication of eating disorders
Nature Reviews Nephrology, Published online: 02 August 2022; doi:10.1038/s41581-022-00610-yKidney disease is an underappreciated medical complication of anorexia nervosa. Further research is needed to clarify the mechanisms that drive kidney disease in patients who restrict caloric intake or engage in purging. Education and awareness are also needed, because kidney disease is often under-recognized by these patients and their clinicians. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 2, 2022 Category: Urology & Nephrology Authors: Leah Puckett Shoshana Mehler Philip Mehler Source Type: research
A pathway of osmotic stress-induced necroptosis
Nature Reviews Nephrology, Published online: 01 August 2022; doi:10.1038/s41581-022-00607-7Necroptosis is a form of regulated necrosis in which RIPK3 is activated by binding to RIP homotypic interaction motif (RHIM)-containing proteins. Now, researchers describe a non-canonical pathway of RIPK3 activation that is triggered by osmotic stress and NHE1-mediated cytosol alkalinization. This previously undescribed mechanism of osmotic stress-induced necroptosis might have implications for treating cancer and other diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 1, 2022 Category: Urology & Nephrology Authors: Alberto Ortiz Ana B. Sanz Source Type: research
Restrictive fluid therapy and high-dose vitamin C in sepsis
Nature Reviews Nephrology, Published online: 01 August 2022; doi:10.1038/s41581-022-00609-5Two recent randomized trials provide evidence to guide the management of sepsis. The CLASSIC trial reports that restrictive fluid therapy has no mortality benefit compared to a standard regimen in patients with septic shock, whereas the LOVIT trial reports that high-dose intravenous vitamin C might be harmful in patients with severe sepsis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 1, 2022 Category: Urology & Nephrology Authors: Mark Philip Plummer Rinaldo Bellomo Source Type: research
Pervasive kidney health inequities for Māori require multi-level attention
Nature Reviews Nephrology, Published online: 29 July 2022; doi:10.1038/s41581-022-00606-8Indigenous Māori experience inequitably high rates of kidney failure and lower rates of kidney transplant, pre-emptive procedures and home dialysis when compared to the New Zealand population as a whole. Prevention strategies in primary care, cultural safety training and routine clinical audit for renal practitioners alongside Indigenous people in governance, management and the clinical workforce would greatly improve Māori outcomes. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 29, 2022 Category: Urology & Nephrology Authors: David Tipene-Leach Rachael Walker Source Type: research
Activation and regulation of alloreactive T cell immunity in solid organ transplantation
Nature Reviews Nephrology, Published online: 27 July 2022; doi:10.1038/s41581-022-00600-0Alloimmune T cell responses have a crucial role in graft rejection. Here, the authors examine the factors that regulate T cell activation, differentiation and function in secondary lymphoid organs and in the graft, including the different pathways of allorecognition, innate–adaptive immunity crosstalk and the role of survival cytokines. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 27, 2022 Category: Urology & Nephrology Authors: Charlotte Duneton Pamela D. Winterberg Mandy L. Ford Source Type: research
UTX regulates accumulation of lipids via kidney serine
Nature Reviews Nephrology, Published online: 26 July 2022; doi:10.1038/s41581-022-00615-7UTX regulates accumulation of lipids via kidney serine (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 26, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Quantifying access to transplantation
Nature Reviews Nephrology, Published online: 25 July 2022; doi:10.1038/s41581-022-00612-wQuantifying access to transplantation (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 25, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Determining treatment response in lupus nephritis
Nature Reviews Nephrology, Published online: 25 July 2022; doi:10.1038/s41581-022-00611-xDetermining treatment response in lupus nephritis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 25, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Stem cell–kidney transplantation in Schimke immuno-osseous dysplasia
Nature Reviews Nephrology, Published online: 25 July 2022; doi:10.1038/s41581-022-00613-9Stem cell–kidney transplantation in Schimke immuno-osseous dysplasia (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 25, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Unmet care needs of minority groups on dialysis
Nature Reviews Nephrology, Published online: 25 July 2022; doi:10.1038/s41581-022-00614-8Unmet care needs of minority groups on dialysis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 25, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Principles of human and mouse nephron development
Nature Reviews Nephrology, Published online: 22 July 2022; doi:10.1038/s41581-022-00598-5Our understanding of nephrogenesis has been aided by studies that have compared features of human and mouse nephrogenesis, and by technological advances in single-cell omics and high-resolution imaging techniques. This Review describes current understanding of nephron patterning, focusing on the processes by which nephron progenitors are recruited into the developing nephron. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 22, 2022 Category: Urology & Nephrology Authors: Jack Schnell MaryAnne Achieng Nils Olof Lindstr öm Source Type: research
Immunometabolic rewiring of tubular epithelial cells in kidney disease
Nature Reviews Nephrology, Published online: 07 July 2022; doi:10.1038/s41581-022-00592-xThe interplay between immunological and metabolic processes is important in a variety of processes. This Review describes how changes in lipid and energy metabolism, driven by receptors of the innate immune system, contribute to the response of tubule epithelial cells to injury and the functional consequences of these intersecting pathways in kidney health and disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 7, 2022 Category: Urology & Nephrology Authors: Sanne van der Rijt Jaklien C. Leemans Sandrine Florquin Riekelt H. Houtkooper Alessandra Tammaro Source Type: research
Kidney xenotransplantation without acute rejection
Nature Reviews Nephrology, Published online: 05 July 2022; doi:10.1038/s41581-022-00602-yKidney xenotransplantation without acute rejection (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 5, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Benefits of CoQ10 supplementation in patients with SRNS due to primary CoQ10 deficiency
Nature Reviews Nephrology, Published online: 05 July 2022; doi:10.1038/s41581-022-00604-wBenefits of CoQ10 supplementation in patients with SRNS due to primary CoQ10 deficiency (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 5, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
A single-cell atlas of DKD treatment responses
Nature Reviews Nephrology, Published online: 05 July 2022; doi:10.1038/s41581-022-00603-xA single-cell atlas of DKD treatment responses (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 5, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
