HLA class II expression levels and alloimmune risk
Nature Reviews Nephrology, Published online: 27 March 2023; doi:10.1038/s41581-023-00714-zHLA class II expression levels and alloimmune risk (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 27, 2023 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Pharmacogenomics in the clinic
Nature Reviews Nephrology, Published online: 24 March 2023; doi:10.1038/s41581-023-00709-wPharmacogenomics in the clinic (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 24, 2023 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Blockchain in nephrology
Nature Reviews Nephrology, Published online: 24 March 2023; doi:10.1038/s41581-023-00707-yBlockchains enable secure data storage, the verification of data origin and accurate registration of changes in information over time. The widespread adoption of blockchain in nephrology could affect clinical practice and research by enhancing the quality of electronic health records and datasets. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 24, 2023 Category: Urology & Nephrology Authors: Tamas Szili-Torok Daan Kremer Stephan J. L. Bakker Uwe J. F. Tietge Martin H. de Borst Source Type: research
Phosphate sensing via PTC glycolysis
Nature Reviews Nephrology, Published online: 24 March 2023; doi:10.1038/s41581-023-00710-3Phosphate sensing via PTC glycolysis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 24, 2023 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Regulated cell death pathways in kidney disease
Nature Reviews Nephrology, Published online: 23 March 2023; doi:10.1038/s41581-023-00694-0Pathways of regulated cell death may contribute to the pathogenesis of various kidney diseases. Here, the authors provide an overview of the relationship between necroptosis, pyroptosis, ferroptosis and apoptosis, the evidence supporting a role for these regulated pathways of necrosis in kidney disease, strategies for therapeutic targeting and research needs. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 23, 2023 Category: Urology & Nephrology Authors: Ana B. Sanz Maria Dolores Sanchez-Ni ño Adrian M. Ramos Alberto Ortiz Source Type: research
Intradialytic acute brain injury
Nature Reviews Nephrology, Published online: 22 March 2023; doi:10.1038/s41581-023-00708-xIntradialytic acute brain injury (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 22, 2023 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney
Nature Reviews Nephrology, Published online: 15 March 2023; doi:10.1038/s41581-023-00689-xFerroptosis is an iron-dependent mechanism of regulated necrosis that is driven by the robust oxidation of polyunsaturated fatty acid-containing phospholipids. This Review describes the fundamental mechanisms of ferroptosis, the potential contribution of ferroptosis to kidney disease and therapeutic strategies for targeting ferroptosis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 15, 2023 Category: Urology & Nephrology Authors: H ülya Bayır Scott J. Dixon Yulia Y. Tyurina John A. Kellum Valerian E. Kagan Source Type: research
The cilia mechanosensation debate gets (bio)physical
Nature Reviews Nephrology, Published online: 13 March 2023; doi:10.1038/s41581-023-00701-4Two studies have applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated that force-based bending of a single nodal axoneme is sufficient to induce intraciliary Ca2+ flux in a PKD2-dependent manner, which propagates to drive asymmetric gene expression. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 13, 2023 Category: Urology & Nephrology Authors: Dagmar Wachten Pleasantine Mill Source Type: research
The role of lysosomes in metabolic and autoimmune diseases
Nature Reviews Nephrology, Published online: 09 March 2023; doi:10.1038/s41581-023-00692-2In this Review, the authors describe the roles of lysosomes in cellular clearance, autophagy, cell signalling, nutrient sensing and metabolic adaptation. They also discuss lysosome abnormalities in metabolic and autoimmune diseases and potential lysosome-targeting therapeutic strategies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 9, 2023 Category: Urology & Nephrology Authors: Fr édéric Gros Sylviane Muller Source Type: research
SGLT2 inhibitors attenuate alterations of kidney metabolic pathways in youth-onset T2DM
Nature Reviews Nephrology, Published online: 27 February 2023; doi:10.1038/s41581-023-00698-wSGLT2 inhibitors attenuate alterations of kidney metabolic pathways in youth-onset T2DM (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 27, 2023 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Experimental evidence for a pathogenic role of anti-PLA2R1 antibodies in membranous nephropathy
Nature Reviews Nephrology, Published online: 27 February 2023; doi:10.1038/s41581-023-00697-xExperimental evidence for a pathogenic role of anti-PLA2R1 antibodies in membranous nephropathy (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 27, 2023 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Mechanism of B cell survival in lupus nephritis
Nature Reviews Nephrology, Published online: 27 February 2023; doi:10.1038/s41581-023-00696-yMechanism of B cell survival in lupus nephritis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 27, 2023 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Targeting iron uptake to correct T cell dysfunction
Nature Reviews Nephrology, Published online: 23 February 2023; doi:10.1038/s41581-023-00695-zTargeting iron uptake to correct T cell dysfunction (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 23, 2023 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup
Nature Reviews Nephrology, Published online: 23 February 2023; doi:10.1038/s41581-023-00683-3Sepsis-associated acute kidney injury (SA-AKI) is linked with poor outcomes in critically ill patients. This Consensus Statement from the Acute Disease Quality Initiative discusses the definition, epidemiology and pathophysiology of SA-AKI, fluid, resuscitation and extracorporeal therapies, and the role of biomarkers in risk stratification and diagnosis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 23, 2023 Category: Urology & Nephrology Authors: Alexander Zarbock Mitra K. Nadim Peter Pickkers Hernando Gomez Samira Bell Michael Joannidis Kianoush Kashani Jay L. Koyner Neesh Pannu Melanie Meersch Thiago Reis Thomas Rimmel é Sean M. Bagshaw Rinaldo Bellomo Vicenzo Cantaluppi Akash Deep Silvia De Ro Source Type: research
Use of convalescent plasma in the treatment of COVID-19
Nature Reviews Nephrology, Published online: 17 February 2023; doi:10.1038/s41581-023-00690-4Use of convalescent plasma in the treatment of COVID-19 (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 17, 2023 Category: Urology & Nephrology Authors: Michael J. Joyner Nigel Paneth Arturo Casadevall Source Type: research
