A CAAR NK cell approach to eliminate pathogenic autoantibody-secreting cells
Nature Reviews Nephrology, Published online: 28 February 2024; doi:10.1038/s41581-024-00824-2A CAAR NK cell approach to eliminate pathogenic autoantibody-secreting cells (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 28, 2024 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Physiological principles underlying the kidney targeting of renal nanomedicines
Nature Reviews Nephrology, Published online: 26 February 2024; doi:10.1038/s41581-024-00819-zRenal nanomedicines may hold promise for the detection and treatment of a variety of kidney diseases. This Review describes how our understanding of the physiological principles that regulate the glomerular filtration, tubular secretion, luminal tubular uptake and re-elimination of nanoparticles in the kidneys may facilitate the selective targeting of nanomedicines to specific segments of the nephron. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 26, 2024 Category: Urology & Nephrology Authors: Yingyu Huang Xuhui Ning Samira Ahrari Qi Cai Nilum Rajora Ramesh Saxena Mengxiao Yu Jie Zheng Source Type: research
Organ trafficking — a continuing challenge
Nature Reviews Nephrology, Published online: 26 February 2024; doi:10.1038/s41581-024-00821-5Global inequities and inequalities, human and health-care crises, transplantation successes in the face of limited organ availability, and desperate donors and recipients underlie the backstory of organ trafficking, namely the exploitation of the most vulnerable. Despite the framework set out by the Declaration of Istanbul for the ethical donation and transplantation of organs, organ trafficking remains a global challenge. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 26, 2024 Category: Urology & Nephrology Authors: Thomas F. Mueller Sanjay Nagral Source Type: research
Long-term health outcomes associated with hydration status
Nature Reviews Nephrology, Published online: 26 February 2024; doi:10.1038/s41581-024-00817-1A number of epidemiological studies have linked markers of underhydration with an increased risk of adverse health outcomes. This Review provides an overview of the mechanisms that regulate body water balance and the adaptive responses to decreased hydration, and describes current understanding of the physiological consequences of underhydration on health outcomes. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 26, 2024 Category: Urology & Nephrology Authors: Natalia I. Dmitrieva Manfred Boehm Paul H. Yancey Sofia Enh örning Source Type: research
Pericyte–stem cell crosstalk in ccRCC
Nature Reviews Nephrology, Published online: 26 February 2024; doi:10.1038/s41581-024-00822-4Pericyte–stem cell crosstalk in ccRCC (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 26, 2024 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Sirtuins in kidney health and disease
Nature Reviews Nephrology, Published online: 06 February 2024; doi:10.1038/s41581-024-00806-4This Review summarizes the roles of sirtuins in kidney development, physiological processes and the pathogenesis of acute and chronic kidney diseases. The authors also highlight the potential of sirtuins as therapeutic targets to limit human kidney disease and renal ageing. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 6, 2024 Category: Urology & Nephrology Authors: Luca Perico Giuseppe Remuzzi Ariela Benigni Source Type: research
Macrophages clean out the tubules
Nature Reviews Nephrology, Published online: 01 February 2024; doi:10.1038/s41581-024-00816-2Macrophages clean out the tubules (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 1, 2024 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Design of a renal-sparing antifungal
Nature Reviews Nephrology, Published online: 30 January 2024; doi:10.1038/s41581-024-00813-5Design of a renal-sparing antifungal (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 30, 2024 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Effects of SGLT2 inhibitors on the metabolic environment and uraemic toxins
Nature Reviews Nephrology, Published online: 30 January 2024; doi:10.1038/s41581-024-00814-4Effects of SGLT2 inhibitors on the metabolic environment and uraemic toxins (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 30, 2024 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
The multifaceted links between hearing loss and chronic kidney disease
Nature Reviews Nephrology, Published online: 29 January 2024; doi:10.1038/s41581-024-00808-2Chronic kidney disease is associated with a graded and independent excess risk of sensorineural hearing loss. This Review describes how disruption of shared signalling pathways that are important for the development of both the ear and the kidney and/or the presence of clinical drivers, such as specific medications or treatments, may underlie these associations. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 29, 2024 Category: Urology & Nephrology Authors: Dina Greenberg Norman D. Rosenblum Marcello Tonelli Source Type: research
A united vision for cardiovascular–kidney–metabolic health
Nature Reviews Nephrology, Published online: 29 January 2024; doi:10.1038/s41581-024-00812-6Improved understanding of the interrelated nature of cardiovascular, kidney and metabolic (CKM) health, the development of novel risk prediction equations, and the availability of powerful new therapies provide an opportunity to change the course of CKM health. Achieving such change at a population level will require additional advances to deliver equitable interdisciplinary care. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 29, 2024 Category: Urology & Nephrology Authors: Susan E. Quaggin Benjamin Magod Source Type: research
The changing landscape of HIV-associated kidney disease
Nature Reviews Nephrology, Published online: 25 January 2024; doi:10.1038/s41581-023-00801-1The availability of antiretroviral therapy has led to a transformation in the spectrum of kidney diseases associated with HIV infection. This Review describes the changing pattern of kidney diseases associated with HIV infection, their risk factors, methods of evaluating kidney function in patients with HIV and current therapeutic approaches. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 25, 2024 Category: Urology & Nephrology Authors: Nina E. Diana Saraladevi Naicker Source Type: research
Metabolic alterations in hereditary and sporadic renal cell carcinoma
Nature Reviews Nephrology, Published online: 22 January 2024; doi:10.1038/s41581-023-00800-2Renal cell carcinoma is a metabolic disease linked to a variety of alterations in genes that regulate cellular metabolism. Here, the authors examine cell-intrinsic metabolic alterations in hereditary and sporadic renal cell carcinoma, and how they can be exploited to develop novel therapeutic interventions. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 22, 2024 Category: Urology & Nephrology Authors: Nathan J. Coffey M. Celeste Simon Source Type: research
Amplifying the voices of patients with kidney disease
Nature Reviews Nephrology, Published online: 22 January 2024; doi:10.1038/s41581-024-00810-8All patients with kidney disease have the right to have a say in their own clinical care, the provision of health services and research into kidney disease. Patient empowerment and advocacy, especially for those whose views are seldom heard, can be enhanced by working together in communities. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 22, 2024 Category: Urology & Nephrology Authors: Miranda Scanlon Source Type: research
Health policy for universal, sustainable and equitable kidney care
Nature Reviews Nephrology, Published online: 18 January 2024; doi:10.1038/s41581-024-00811-7Treatment of chronic kidney disease requires a comprehensive approach including universal access to early diagnosis and to medications that can slow disease progression. Such equitable access is not only an ethical requirement but can also reduce the financial and human costs of advancing kidney and cardiovascular disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 18, 2024 Category: Urology & Nephrology Authors: Ricardo Silvari ño Laura Sol á Source Type: research
