Introducing routine genetic testing for patients with CKD
Introducing routine genetic testing for patients with CKD, Published online: 22 March 2019; doi:10.1038/s41581-019-0140-9Chronic kidney disease (CKD) is often clinically silent and traditional clinical data alone cannot differentiate disease subtypes. A recent study of the genetic basis of CKD in adults that examined the prevalence of monogenic kidney disease aetiologies supports the use of genetic analysis to improve diagnostics and treatment in CKD. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 22, 2019 Category: Urology & Nephrology Authors: Asaf Vivante Karl Skorecki Source Type: research

Epigenetics and epigenomics in diabetic kidney disease and metabolic memory
Epigenetics and epigenomics in diabetic kidney disease and metabolic memory, Published online: 20 March 2019; doi:10.1038/s41581-019-0135-6This Review describes the current understanding of the role of epigenetics and epigenomics in diabetic kidney disease (DKD) and how epigenetic mechanisms might contribute to metabolic memory. The authors also discuss how epigenetic factors and non-coding RNAs could be used as biomarkers and drug targets for DKD diagnosis, prognosis and treatment. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: Mitsuo Kato Rama Natarajan Source Type: research

Not your usual parietal cell
Not your usual parietal cell, Published online: 18 March 2019; doi:10.1038/s41581-019-0141-8Not your usual parietal cell (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 18, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Glycosylation in health and disease
Glycosylation in health and disease, Published online: 11 March 2019; doi:10.1038/s41581-019-0129-4Glycosylation refers to the addition of carbohydrate chains to proteins and lipids. In this Review, the authors discuss the broad role of glycans in immunity, cancer, xenotransplantation and glomerular filtration and the potential of ‘glycomedicine’. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 11, 2019 Category: Urology & Nephrology Authors: Colin Reily Tyler J. Stewart Matthew B. Renfrow Jan Novak Source Type: research

Evidence-based therapy for undocumented immigrants with ESRD
Evidence-based therapy for undocumented immigrants with ESRD, Published online: 08 March 2019; doi:10.1038/s41581-019-0137-4Haemodialysis options for undocumented immigrants with end-stage renal disease range from standard of care thrice-weekly treatments to emergency-only haemodialysis. This latter approach is associated with poor patient outcomes and high costs. The time has come for the nephrology community to demand an end to the practice of emergency-only haemodialysis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 8, 2019 Category: Urology & Nephrology Authors: Rudolph A. Rodriguez Source Type: research

Tubuloids for modelling kidney disease
Tubuloids for modelling kidney disease, Published online: 05 March 2019; doi:10.1038/s41581-019-0138-3Tubuloids for modelling kidney disease (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 5, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Nanosensors enable early detection of acute T cell-mediated rejection of transplants
Nanosensors enable early detection of acute T cell-mediated rejection of transplants, Published online: 05 March 2019; doi:10.1038/s41581-019-0134-7Nanosensors enable early detection of acute T cell-mediated rejection of transplants (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 5, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

A materials approach for kidney organoids
A materials approach for kidney organoids, Published online: 05 March 2019; doi:10.1038/s41581-019-0139-2A materials approach for kidney organoids (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 5, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

ABCF1 switches off inflammation in sepsis
ABCF1 switches off inflammation in sepsis, Published online: 01 March 2019; doi:10.1038/s41581-019-0136-5ABCF1 switches off inflammation in sepsis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 1, 2019 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Macrophages support kidney and vasculature assembly in development
Macrophages support kidney and vasculature assembly in development, Published online: 27 February 2019; doi:10.1038/s41581-019-0133-8Macrophages support kidney and vasculature assembly in development (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 27, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Succinate homeostasis protects against lithogenesis and hypertension
Succinate homeostasis protects against lithogenesis and hypertension, Published online: 25 February 2019; doi:10.1038/s41581-019-0132-9Succinate homeostasis protects against lithogenesis and hypertension (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 25, 2019 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Immune mechanisms of salt-sensitive hypertension and renal end-organ damage
Immune mechanisms of salt-sensitive hypertension and renal end-organ damage, Published online: 25 February 2019; doi:10.1038/s41581-019-0121-zImmune mechanisms have important roles in the development of hypertension and end-organ damage. In this Review, David Mattson discusses these mechanisms with a focus on salt-sensitive hypertension and adaptive immunity. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 25, 2019 Category: Urology & Nephrology Authors: David L. Mattson Source Type: research

Ubiquitylation of PTEN drives fibrosis in diabetic kidney disease
Ubiquitylation of PTEN drives fibrosis in diabetic kidney disease, Published online: 25 February 2019; doi:10.1038/s41581-019-0130-yUbiquitylation of PTEN drives fibrosis in diabetic kidney disease (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 25, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Immunity, microbiota and kidney disease
Immunity, microbiota and kidney disease, Published online: 22 February 2019; doi:10.1038/s41581-019-0118-7This Review describes the reciprocal interactions between the immune system and the intestinal microbiota, focusing on components of the immune system that drive chronic diseases that involve the kidney. The authors also discuss limitations of current approaches to microbiota research and emphasize the need to move beyond studies of correlation to causation. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 22, 2019 Category: Urology & Nephrology Authors: Felix Knauf J. Richard Brewer Richard A. Flavell Source Type: research

Pre-eclampsia: pathogenesis, novel diagnostics and therapies
Pre-eclampsia: pathogenesis, novel diagnostics and therapies, Published online: 21 February 2019; doi:10.1038/s41581-019-0119-6Pre-eclampsia is associated with substantial maternal and fetal morbidity and mortality worldwide. Here, the authors discuss the epidemiology, pathogenesis and current and future treatment of pre-eclampsia with a focus on the role of angiogenic imbalance. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 21, 2019 Category: Urology & Nephrology Authors: Elizabeth A. Phipps Ravi Thadhani Thomas Benzing S. Ananth Karumanchi Source Type: research

PIVOTAL trial: iron loading improves clinical outcomes
PIVOTAL trial: iron loading improves clinical outcomes, Published online: 21 February 2019; doi:10.1038/s41581-019-0128-5The PIVOTAL trial shows that proactive intravenous (i.v.) iron administration reduces cardiovascular events and deaths, transfusions and erythropoiesis-stimulating agent doses and does not increase infections in patients on haemodialysis. These findings upend the warnings of guidelines and experts about the dangers of i.v. iron and prove that maintaining low iron stores is harmful. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 21, 2019 Category: Urology & Nephrology Authors: Daniel W. Coyne Source Type: research

Fluid flow enhances vascularization and maturation of kidney organoids
Fluid flow enhances vascularization and maturation of kidney organoids, Published online: 18 February 2019; doi:10.1038/s41581-019-0126-7Fluid flow enhances vascularization and maturation of kidney organoids (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 18, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Modelling diabetic vasculopathy with human vessel organoids
Modelling diabetic vasculopathy with human vessel organoids, Published online: 18 February 2019; doi:10.1038/s41581-019-0125-8A new study reports that human blood vessel organoids can be generated through the directed differentiation of human pluripotent stem cells. Use of these blood vessel organoids to model diabetic vasculopathy led to the identification of a new potential therapeutic target, suggesting that this system could have translational value for studies of diabetes complications. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 18, 2019 Category: Urology & Nephrology Authors: Ryuji Morizane Source Type: research

Growing mouse kidneys in rats
Growing mouse kidneys in rats, Published online: 18 February 2019; doi:10.1038/s41581-019-0127-6Growing mouse kidneys in rats (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 18, 2019 Category: Urology & Nephrology Authors: Katharine H. Wrighton Source Type: research

Cyclin G1 drives maladaptive renal repair
Cyclin G1 drives maladaptive renal repair, Published online: 15 February 2019; doi:10.1038/s41581-019-0124-9Cyclin G1 drives maladaptive renal repair (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 15, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Albuminuria: a target for clinical trials in kidney disease?
Albuminuria: a target for clinical trials in kidney disease?, Published online: 14 February 2019; doi:10.1038/s41581-019-0123-xA reduction in proteinuria and albuminuria has long been proposed as a surrogate biomarker for clinically validated end points for interventional trials in patients with kidney disease. Taken together, the findings of two recent landmark meta-analyses present a formidable argument favouring such surrogacy but some uncertainty remains. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 14, 2019 Category: Urology & Nephrology Authors: Richard J. Glassock Source Type: research

Some nephron progenitors fail to commit
Some nephron progenitors fail to commit, Published online: 08 February 2019; doi:10.1038/s41581-019-0122-ySome nephron progenitors fail to commit (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 8, 2019 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Cellular signalling by primary cilia in development, organ function and disease
Cellular signalling by primary cilia in development, organ function and disease, Published online: 07 February 2019; doi:10.1038/s41581-019-0116-9This Review describes the main signalling pathways that are coordinated by primary cilia to control developmental processes, tissue plasticity and organ function and how defects in the output of ciliary signalling events are coupled to developmental disorders and disease progression. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 7, 2019 Category: Urology & Nephrology Authors: Zeinab Anvarian Kirk Mykytyn Saikat Mukhopadhyay Lotte Bang Pedersen S øren Tvorup Christensen Source Type: research

Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling
Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling, Published online: 06 February 2019; doi:10.1038/s41581-019-0111-1The plasma accumulation of uraemic solutes seen in chronic kidney disease is associated with dysregulated homeostasis. In this Review, Nigam and Bush discuss uraemic syndrome in the context of the remote sensing and signalling hypothesis, which describes small-molecule-mediated communication between tissues and organs. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 6, 2019 Category: Urology & Nephrology Authors: Sanjay K. Nigam Kevin T. Bush Source Type: research

Kidney disease in the Global Burden of Disease Study 2017
Kidney disease in the Global Burden of Disease Study 2017, Published online: 05 February 2019; doi:10.1038/s41581-019-0120-0The analyses in the 2017 Global Burden of Disease Study demonstrate the growing burden of chronic kidney disease (CKD), mainly driven by population ageing; absolute levels for every CKD metric considered rose significantly, whereas age-standardized rates were fairly stable. The prevalence of key metabolic CKD risk factors, particularly obesity, also show a worrying increase. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 5, 2019 Category: Urology & Nephrology Authors: Simon D. S. Fraser Paul J. Roderick Source Type: research

The genetic changes of Wilms tumour
The genetic changes of Wilms tumour, Published online: 31 January 2019; doi:10.1038/s41581-019-0112-0Wilms tumour is the most common renal malignancy of childhood. Here, the authors review the genetic landscape of Wilms tumour and discuss how precision medicine guided by genomic information might lead to new therapeutic approaches and improve patient survival. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 31, 2019 Category: Urology & Nephrology Authors: Taryn Dora Treger Tanzina Chowdhury Kathy Pritchard-Jones Sam Behjati Source Type: research

Macrophages: versatile players in renal inflammation and fibrosis
Macrophages: versatile players in renal inflammation and fibrosis, Published online: 28 January 2019; doi:10.1038/s41581-019-0110-2Macrophages are versatile immune cells that protect the host against infection but can also promote chronic inflammation and fibrosis. In this Review, the authors discuss the diverse roles of macrophages in acute and chronic renal pathology as well as potential therapeutic targets. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 28, 2019 Category: Urology & Nephrology Authors: Patrick Ming-Kuen Tang David J. Nikolic-Paterson Hui-Yao Lan Source Type: research

C3 glomerulopathy — understanding a rare complement-driven renal disease
C3 glomerulopathy — understanding a rare complement-driven renal diseaseC3 glomerulopathy — understanding a rare complement-driven renal disease, Published online: 28 January 2019; doi:10.1038/s41581-018-0107-2This Review presents our current understanding of C3 glomerulopathy. Smith et al. discuss the histopathological diagnosis and the crucial pathogenic role of complement dysregulation. Genetic and acquired drivers of C3 glomerulopathy, potential biomarkers and available treatments are highlighted. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 28, 2019 Category: Urology & Nephrology Authors: Richard J. H. Smith Gerald B. Appel Anna M. Blom H. Terence Cook Vivette D D ’Agati Fadi Fakhouri V éronique Fremeaux-Bacchi Mih ály Józsi David Kavanagh John D. Lambris Marina Noris Matthew C. Pickering Giuseppe Remuzzi Santiago Rodriguez de C órdo Source Type: research

Nitric oxide protects against AKI by reprogramming metabolism
Nitric oxide protects against AKI by reprogramming metabolism, Published online: 24 January 2019; doi:10.1038/s41581-019-0113-zNew findings demonstrate that endothelial nitric oxide synthase regulates major metabolic pathways in the kidney proximal tubule, which confers protection against oxidative stress during acute kidney injury (AKI). These findings give new insights into AKI pathophysiology and nitric oxide biology, and identify new targets for the treatment of AKI. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 24, 2019 Category: Urology & Nephrology Authors: Pierre-Yves Martin Sophie de Seigneux Source Type: research

The genetic architecture of blood pressure
The genetic architecture of blood pressure, Published online: 22 January 2019; doi:10.1038/s41581-019-0117-8The genetic architecture of blood pressure (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 22, 2019 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

DNA methylation links intrauterine stress with abnormal nephrogenesis
DNA methylation links intrauterine stress with abnormal nephrogenesis, Published online: 22 January 2019; doi:10.1038/s41581-019-0114-yScientists have long wondered how maternal diabetes, malnutrition and placental dysfunction impair fetal nephrogenesis. A new study discovered a link between prenatal metabolic stress and nephron deficit via dysregulation of DNA methylation — an epigenetic mechanism that is essential for the renewal and differentiation of nephron progenitors. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 22, 2019 Category: Urology & Nephrology Authors: Samir S. El-Dahr Source Type: research

CNVs in CAKUT
CNVs in CAKUT, Published online: 21 January 2019; doi:10.1038/s41581-019-0115-xCNVs in CAKUT (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 21, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Evolving concepts in the pathogenesis of uraemic cardiomyopathy
Evolving concepts in the pathogenesis of uraemic cardiomyopathy, Published online: 21 January 2019; doi:10.1038/s41581-018-0101-8Uraemic cardiomyopathy is the major phenotype of fatal cardiac disease in patients with end-stage renal disease. This Review focuses on the molecular mechanisms of uraemic cardiomyopathy, crosstalk between these mechanisms and implications for therapy (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 21, 2019 Category: Urology & Nephrology Authors: Xiaoliang Wang Joseph I. Shapiro Source Type: research

Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications
Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications, Published online: 16 January 2019; doi:10.1038/s41581-018-0103-6A growing body of evidence suggests that epigenetic regulation is involved in the process of acute kidney injury (AKI) and kidney repair. This Review provides a general overview of the main epigenetic mechanisms that have been linked to AKI and discusses the challenges and therapeutic implications of these findings. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 16, 2019 Category: Urology & Nephrology Authors: Chunyuan Guo Guie Dong Xinling Liang Zheng Dong Source Type: research

Local solutions save young lives
Local solutions save young lives, Published online: 07 January 2019; doi:10.1038/s41581-018-0109-0Peritoneal dialysis has many advantages over haemodialysis in the treatment of acute kidney injury (AKI) in low-resource settings. One limitation, however, is the availability of commercial dialysis fluid. Following the International Society of Peritoneal Dialysis AKI guidelines, a frontline hospital in Cameroon now shows that locally prepared fluids are safe and effective. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 7, 2019 Category: Urology & Nephrology Authors: Simon J. Davies Source Type: research

Progress in the understanding of polycystic kidney disease
Progress in the understanding of polycystic kidney disease, Published online: 03 January 2019; doi:10.1038/s41581-018-0108-1The function of polycystin proteins and the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) are not well understood. Studies published in 2018 made important contributions to the understanding of genetic mechanisms, the structure of the polycystin complex and the roles of G-protein signalling and the immune system in ADPKD. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 3, 2019 Category: Urology & Nephrology Authors: Vicente E. Torres Peter C. Harris Source Type: research

Endothelium structure and function in kidney health and disease
Endothelium structure and function in kidney health and disease, Published online: 03 January 2019; doi:10.1038/s41581-018-0098-zThe kidney is a highly vascularized organ and contains a remarkable diversity of endothelial cell populations. Here, the authors describe unique features of the healthy renal endothelium and the pathological mechanisms that can lead to endothelial damage in renal disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 3, 2019 Category: Urology & Nephrology Authors: Noemie Jourde-Chiche Fadi Fakhouri Laetitia Dou Jeremy Bellien St éphane Burtey Marie Frimat Pierre-Andr é Jarrot Gilles Kaplanski Moglie Le Quintrec Vincent Pernin Claire Rigothier Marion Sall ée Veronique Fremeaux-Bacchi Dominique Guerrot Lubka T. Ro Source Type: research

Sodium transport in diabetes: two sides to the coin
Sodium transport in diabetes: two sides to the coin, Published online: 22 December 2018; doi:10.1038/s41581-018-0106-3New findings implicate sodium transport in α-cell secretory dysfunction, leading to impaired counter-regulatory responses in diabetes. However, these findings also raise important questions about the tissue-specific roles of sodium transport and suggest that inhibitors of sodium transport may have potentially divergent roles in the pancreas, kidney and heart. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 22, 2018 Category: Urology & Nephrology Authors: Julie A. Lovshin David Z. Cherney Source Type: research

Publisher Correction: The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group
Publisher Correction: The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group, Published online: 19 December 2018; doi:10.1038/s41581-018-0102-7Publisher Correction: The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 19, 2018 Category: Urology & Nephrology Authors: Nelson Leung Frank Bridoux Vecihi Batuman Aristeidis Chaidos Paul Cockwell Vivette D. D ’Agati Angela Dispenzieri Fernando C. Fervenza Jean- Paul Fermand Simon Gibbs Julian D. Gillmore Guillermo A. Herrera Arnaud Jaccard Dragan Jevremovic Efstathios Kas Source Type: research

Single-cell genomics and gene editing: implications for nephrology
Single-cell genomics and gene editing: implications for nephrology, Published online: 19 December 2018; doi:10.1038/s41581-018-0094-3Discoveries in 2018 using single-cell sequencing and gene-editing technologies have revealed their transformative potential for the investigation of kidney physiology and disease. Their promise is matched by the speed of their evolution. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 19, 2018 Category: Urology & Nephrology Authors: Parker C. Wilson Benjamin D. Humphreys Source Type: research

Author Correction: Estimated GFR: time for a critical appraisal
Author Correction: Estimated GFR: time for a critical appraisalAuthor Correction: Estimated GFR: time for a critical appraisal, Published online: 18 December 2018; doi:10.1038/s41581-018-0105-4Author Correction: Estimated GFR: time for a critical appraisal (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 18, 2018 Category: Urology & Nephrology Authors: Esteban Porrini Piero Ruggenenti Sergio Luis-Lima Fabiola Carrara Alejandro Jim énez Aiko P. J. de Vries Armando Torres Flavio Gaspari Giuseppe Remuzzi Source Type: research

Sepsis halts renal protein translation
Sepsis halts renal protein translation, Published online: 18 December 2018; doi:10.1038/s41581-018-0104-5Sepsis halts renal protein translation (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 18, 2018 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Protecting the kidney against autoimmunity and inflammation
Protecting the kidney against autoimmunity and inflammation, Published online: 17 December 2018; doi:10.1038/s41581-018-0097-0Numerous exciting studies that advanced our understanding of immune-mediated kidney disease were published in 2018. Whereas most of these studies analysed the role of pro-inflammatory mediators, several novel anti-inflammatory mechanisms were discovered that involve immune cells and mediators with previously unrecognized protective roles in renal disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 17, 2018 Category: Urology & Nephrology Authors: Christian Kurts Catherine Meyer-Schwesinger Source Type: research

The handwriting is on the wall: there will soon be a drug for AKI
The handwriting is on the wall: there will soon be a drug for AKI, Published online: 13 December 2018; doi:10.1038/s41581-018-0095-2With many failures, a sense of helplessness has overshadowed the field of acute kidney injury (AKI). Publications in 2018 offer new hope: better drug targets, better end points and improved understanding of conditions that cause AKI and its complications bring promise that a drug will soon be available. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 13, 2018 Category: Urology & Nephrology Authors: John A. Kellum Dana Y. Fuhrman Source Type: research

ARP3 in podocyte development
ARP3 in podocyte development, Published online: 12 December 2018; doi:10.1038/s41581-018-0100-9ARP3 in podocyte development (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 12, 2018 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Author Correction: Lipid management in patients with chronic kidney disease
Author Correction: Lipid management in patients with chronic kidney disease, Published online: 11 December 2018; doi:10.1038/s41581-018-0099-yAuthor Correction: Lipid management in patients with chronic kidney disease (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 11, 2018 Category: Urology & Nephrology Authors: Charles J. Ferro Patrick B. Mark Mehmet Kanbay Pantelis Sarafidis Gunnar H. Heine Patrick Rossignol Ziad A. Massy Francesca Mallamaci Jose M. Valdivielso Jolanta Malyszko Marianne C. Verhaar Robert Ekart Raymond Vanholder Gerard London Alberto Ortiz Carmi Source Type: research

A promising outlook for diabetic kidney disease
A promising outlook for diabetic kidney disease, Published online: 10 December 2018; doi:10.1038/s41581-018-0092-5In 2018, consolidating evidence for renoprotective benefits was seen with respect to sodium–glucose cotransporter 2 inhibitors and glucagon-like peptide 1 agonists, which are currently being incorporated into clinical practice. The focus now turns to novel therapeutic targets to optimize renoprotection as diabetic kidney disease grows to epidemic proportions worldwide. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 10, 2018 Category: Urology & Nephrology Authors: Mark Cooper Annabelle M. Warren Source Type: research

A CD4+ T cell population provides B cell help in systemic lupus erythematosus
A CD4+ T cell population provides B cell help in systemic lupus erythematosusA CD4+ T cell population provides B cell help in systemic lupus erythematosus, Published online: 10 December 2018; doi:10.1038/s41581-018-0096-1A CD4+ T cell population provides B cell help in systemic lupus erythematosus (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 10, 2018 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Estimated GFR: time for a critical appraisal
Estimated GFR: time for a critical appraisal, Published online: 05 December 2018; doi:10.1038/s41581-018-0080-9In this Perspectives article, Porrini and colleagues appraise the results of studies that have compared the performance of formulae developed to estimate glomerular filtration rate (GFR) against measured GFR reference methods. They contend that the persistence of errors in GFR estimation formulae indicates an inadequacy of serum creatinine and cystatin C levels as markers of actual renal function. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 5, 2018 Category: Urology & Nephrology Authors: Esteban Porrini Piero Ruggenenti Sergio Luis-Lima Fabiola Carrara Alejandro Jim énez Aiko de Vries Armando Torres Flavio Gaspari Giuseppe Remuzzi Source Type: research

A novel RNA interference approach to targeting sFLT1 in pre-eclampsia
A novel RNA interference approach to targeting sFLT1 in pre-eclampsia, Published online: 04 December 2018; doi:10.1038/s41581-018-0093-4A novel RNA interference approach to targeting sFLT1 in pre-eclampsia (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 4, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research