Inequities in kidney health and kidney care
Nature Reviews Nephrology, Published online: 14 August 2023; doi:10.1038/s41581-023-00745-6Kidney disease risk and outcomes are strongly associated with inequities that occur across the entire clinical course of the disease. The authors of this Review describe the different inequities that affect kidney health and care worldwide, and consider potential solutions to help to mitigate these. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 14, 2023 Category: Urology & Nephrology Authors: Raymond Vanholder Lieven Annemans Marion Braks Edwina A. Brown Priya Pais Tanjala S. Purnell Simon Sawhney Nicole Scholes-Robertson B énédicte Stengel Elliot K. Tannor Vladimir Tesar Arjan van der Tol Val érie A. Luyckx Source Type: research

Increasing diversity and inclusion in nephrology clinical trials
Nature Reviews Nephrology, Published online: 07 August 2023; doi:10.1038/s41581-023-00756-3Racial and ethnic minoritized populations are underrepresented in clinical trials in nephrology, but overrepresented in adverse kidney disease outcomes. Targeted enrolment, revision of problematic policies, inclusion of minoritized populations in trial planning, and language-, race- and ethnicity-concordant investigative teams can improve representation in clinical trials. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 7, 2023 Category: Urology & Nephrology Authors: Bessie A. Young Sylvia E. Rosas Source Type: research

Reducing preventable acute kidney injury in a hospital setting
Nature Reviews Nephrology, Published online: 01 August 2023; doi:10.1038/s41581-023-00755-4Acute kidney injury (AKI) is a global concern that affects patient outcomes and resource utilization. An effective educational programme aimed at improving early AKI identification, triaging and treatment, using risk scores and care bundles coupled with access to point-of-care diagnostics, can help to prevent AKI-related deaths in regions with limited resources. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 1, 2023 Category: Urology & Nephrology Authors: Rolando Claure-Del Granado Source Type: research

The genetics and pathogenesis of CAKUT
Nature Reviews Nephrology, Published online: 31 July 2023; doi:10.1038/s41581-023-00742-9Here, the authors provide an overview of genetic causes of CAKUT and their impact on signalling pathways during nephrogenesis. They also discuss the impact of a molecular genetic diagnosis on the clinical care and potentially the personalized treatment of patients with CAKUT. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 31, 2023 Category: Urology & Nephrology Authors: Caroline M. Kolvenbach Shirlee Shril Friedhelm Hildebrandt Source Type: research

Immune-checkpoint inhibition to slow cyst growth
Nature Reviews Nephrology, Published online: 31 July 2023; doi:10.1038/s41581-023-00751-8Immune-checkpoint inhibition to slow cyst growth (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 31, 2023 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Cryopreservation breaks the organ transplant time barrier
Nature Reviews Nephrology, Published online: 28 July 2023; doi:10.1038/s41581-023-00750-9In a ground-breaking development, rat kidneys have been cryopreserved for an unprecedented duration of 100 days and subsequently transplanted successfully after nano-rewarming. This extraordinary achievement opens new possibilities for the field of organ banking. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 28, 2023 Category: Urology & Nephrology Authors: Marlon J. A. de Haan Ton J. Rabelink Source Type: research

Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
Nature Reviews Nephrology, Published online: 27 July 2023; doi:10.1038/s41581-023-00741-wChronic kidney disease is characterized by dyslipidaemia and lipid accumulation in the kidney. In this Review, the authors examine the evidence that links alterations in lipid metabolism to kidney injury and progression of kidney disease, and explore potential lipid-targeted therapeutic approaches. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 27, 2023 Category: Urology & Nephrology Authors: Alla Mitrofanova Sandra Merscher Alessia Fornoni Source Type: research

Urinary CXCL9: a biomarker for AIN
Nature Reviews Nephrology, Published online: 27 July 2023; doi:10.1038/s41581-023-00749-2Urinary CXCL9: a biomarker for AIN (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 27, 2023 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

GFR slope as a surrogate marker for future kidney failure
Nature Reviews Nephrology, Published online: 26 July 2023; doi:10.1038/s41581-023-00748-3Kidney failure is a serious but rare consequence of progressive chronic kidney disease. A meta-analysis of individual participant-level trial data, across heterogeneous treatments and disease groups, has shown glomerular filtration rate (GFR) slope to be a valid, fit-for-purpose and robust surrogate marker of kidney failure. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 26, 2023 Category: Urology & Nephrology Authors: Jennifer S. Lees Patrick B. Mark Source Type: research

Historical redlining and kidney failure
Nature Reviews Nephrology, Published online: 26 July 2023; doi:10.1038/s41581-023-00754-5Historical redlining and kidney failure (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 26, 2023 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Inflammation and gut dysbiosis as drivers of CKD–MBD
Nature Reviews Nephrology, Published online: 24 July 2023; doi:10.1038/s41581-023-00736-7This Review examines the role of alterations in the gut microbial ecosystem, as well as inflammation and oxidative stress, in the bone and mineral disorder that affects patients with chronic kidney disease. The authors also explore novel therapeutic options that can target these disease factors. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 24, 2023 Category: Urology & Nephrology Authors: Pieter Evenepoel Peter Stenvinkel Catherine Shanahan Roberto Pacifici Source Type: research

Uropathogen and host responses in pyelonephritis
Nature Reviews Nephrology, Published online: 21 July 2023; doi:10.1038/s41581-023-00737-6The bladder and kidney engage adaptive and innate immune responses to prevent urinary tract infections and minimize tissue injury following infection. Here, the authors describe the mechanisms used by uropathogenic bacteria to establish and promote kidney infection, as well as the immune defence mechanisms used by resident kidney cells and infiltrating immune cells to eradicate infection. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 21, 2023 Category: Urology & Nephrology Authors: Laura Schwartz Juan de Dios Ruiz-Rosado Emily Stonebrook Brian Becknell John David Spencer Source Type: research

Disasters and kidney care: pitfalls and solutions
Nature Reviews Nephrology, Published online: 21 July 2023; doi:10.1038/s41581-023-00743-8During disasters, the morbidity and mortality of patients with kidney disease far exceeds that of the general population. Here, the authors discuss the medical and logistical problems that are faced by these patients and their care-givers during mass disasters and suggest pragmatic approaches to improve patient outcomes. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 21, 2023 Category: Urology & Nephrology Authors: Mehmet Sukru Sever Valerie Luyckx Marcello Tonelli Rumeyza Kazancioglu Darlene Rodgers Dani Gallego Serhan Tuglular Raymond Vanholder Source Type: research

Author Correction: Beyond state borders: transforming dialysis care for undocumented immigrants
Nature Reviews Nephrology, Published online: 20 July 2023; doi:10.1038/s41581-023-00746-5Author Correction: Beyond state borders: transforming dialysis care for undocumented immigrants (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 20, 2023 Category: Urology & Nephrology Authors: Devon Cassidy Katherine Rizzolo Neil R. Powe Lilia Cervantes Source Type: research

Aquaporin water channels: roles beyond renal water handling
Nature Reviews Nephrology, Published online: 17 July 2023; doi:10.1038/s41581-023-00734-9Aquaporins have diverse roles in various homeostatic and physiological systems beyond their role in renal water handling. This Review describes the role of mammalian aquaporins in the transport of solutes other than water and their involvement in processes such as metabolism, cellular migration, cell adhesion, cell polarity and cell signalling. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 17, 2023 Category: Urology & Nephrology Authors: Fr édéric H. Login Lene N. Nejsum Source Type: research