The role of claudins in homeostasis
Nature Reviews Nephrology, Published online: 21 June 2023; doi:10.1038/s41581-023-00731-yMeoli and Günzel elucidate the role of claudins (a family of tight junction proteins) in maintaining electrolyte and water homeostasis. With this Review, the authors aim to stimulate investigations on claudins as prognostic markers or as druggable targets in kidney disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 21, 2023 Category: Urology & Nephrology Authors: Luca Meoli Dorothee G ünzel Source Type: research
Circulating non-coding RNAs in chronic kidney disease and its complications
Nature Reviews Nephrology, Published online: 07 June 2023; doi:10.1038/s41581-023-00725-wCirculating non-coding RNAs (ncRNAs) are derived from specific cell types and can be directly transferred to a variety of cells to affect their function. This Review describes the relevance of circulating ncRNAs to the development of kidney disease and discusses the potential use of circulating ncRNAs as diagnostic factors and therapeutic targets. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 7, 2023 Category: Urology & Nephrology Authors: Anton Jan van Zonneveld Qiao Zhao Joris I. Rotmans Roel Bijkerk Source Type: research
Portable, wearable and implantable artificial kidney systems: needs, opportunities and challenges
Nature Reviews Nephrology, Published online: 05 June 2023; doi:10.1038/s41581-023-00726-9Portable, wearable and implantable artificial kidney systems require compact and efficient dialysate regeneration systems and novel membranes for improved toxin removal and long-term patency. Here, the authors discuss efforts to overcome these challenges and future perspectives for achieving miniaturized dialysis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 5, 2023 Category: Urology & Nephrology Authors: David Loureiro Ramada Joost de Vries Jeroen Vollenbroek Nazia Noor Odyl ter Beek Silvia M. Mih ăilă Fokko Wieringa Rosalinde Masereeuw Karin Gerritsen Dimitrios Stamatialis Source Type: research
Dysfunctional UCH-L1 inhibits proteostasis
Nature Reviews Nephrology, Published online: 31 May 2023; doi:10.1038/s41581-023-00730-zDysfunctional UCH-L1 inhibits proteostasis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 31, 2023 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Chronic kidney disease promotes ageing in a multiorgan disease network
Nature Reviews Nephrology, Published online: 26 May 2023; doi:10.1038/s41581-023-00729-6Human ageing trajectories are highly individual and dependent on genetic and non-genetic factors. An analysis of the interconnectivity of distinct age-related chronic diseases shows that organ-specific chronic diseases accelerate the ageing of other organ systems, which has important implications for mortality. Notably, chronic kidney disease was identified a highly important risk factor for the ageing of other organ systems. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 26, 2023 Category: Urology & Nephrology Authors: Thomas Benzing Bj örn Schumacher Source Type: research
Pathogenic cellular and molecular mediators in lupus nephritis
Nature Reviews Nephrology, Published online: 24 May 2023; doi:10.1038/s41581-023-00722-zThis Review examines the contribution of innate and adaptive immune cells to the pathogenesis of lupus nephritis, including new insights into the molecular mechanisms that drive this disease, such as recognition of endogenous chromatin by endosomal and cytosolic nucleic acid sensors. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 24, 2023 Category: Urology & Nephrology Authors: Chandra Mohan Ting Zhang Chaim Putterman Source Type: research
The kidney is a novel target of metformin
Nature Reviews Nephrology, Published online: 17 May 2023; doi:10.1038/s41581-023-00728-7The kidney is a novel target of metformin (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 17, 2023 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Identification of erythropoietin-producing cells
Nature Reviews Nephrology, Published online: 15 May 2023; doi:10.1038/s41581-023-00727-8Identification of erythropoietin-producing cells (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 15, 2023 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Pathogenesis of autoimmune disease
Nature Reviews Nephrology, Published online: 10 May 2023; doi:10.1038/s41581-023-00720-1Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell and T cell reactivity to normal host constituents. This Review provides an overview of the basis of autoimmune disease with a focus on autoantibodies, given their valuable role as markers for diagnosis, classification and of disease activity. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 10, 2023 Category: Urology & Nephrology Authors: David S. Pisetsky Source Type: research
Key role of α-synuclein in Fabry nephropathy
Nature Reviews Nephrology, Published online: 02 May 2023; doi:10.1038/s41581-023-00723-yKey role of α-synuclein in Fabry nephropathy (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 2, 2023 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Mannose as a driver of γδ T cell kidney infiltration
Nature Reviews Nephrology, Published online: 02 May 2023; doi:10.1038/s41581-023-00724-xMannose as a driver of γδ T cell kidney infiltration (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 2, 2023 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Inaxaplin for the treatment of APOL1-associated kidney disease
Nature Reviews Nephrology, Published online: 27 April 2023; doi:10.1038/s41581-023-00721-0APOL1 risk variants are associated with an increased risk of chronic kidney disease. Findings from a new study demonstrate that a small molecule, inaxaplin, inhibits APOL1 channel function; furthermore, inaxaplin reduced proteinuria in patients with focal segmental glomerulosclerosis and two APOL1 risk variants. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 27, 2023 Category: Urology & Nephrology Authors: Rasheed Gbadegesin Brandon Lane Source Type: research
Intersectionality as a lens for achieving kidney health justice
Nature Reviews Nephrology, Published online: 20 April 2023; doi:10.1038/s41581-023-00715-yIndividuals who are members of multiple marginalized populations experience multiple axes of oppression and discrimination. Such intersectional discrimination can have interactive, negative effects on all aspects of life, including health. To achieve health equity, intersectional-discrimination-induced kidney harms must be examined, measured and mitigated. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 20, 2023 Category: Urology & Nephrology Authors: Elle Lett Carmen H. Logie Dinushika Mohottige Source Type: research
Interim analysis indicates sparsentan PROTECTs in IgAN
Nature Reviews Nephrology, Published online: 20 April 2023; doi:10.1038/s41581-023-00719-8Interim analysis indicates sparsentan PROTECTs in IgAN (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 20, 2023 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Mentorship in the lives of scholars
Nature Reviews Nephrology, Published online: 19 April 2023; doi:10.1038/s41581-023-00718-9Mentoring is an essential component of scientific leadership and can have a profound impact on the development and life course of the mentee. Isi Ero-Tolliver, Dean of the School of Science at Hampton University, describes the life-changing and long-lasting effects of mentorship and why it is important to invest time and effort in mentoring. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 19, 2023 Category: Urology & Nephrology Authors: Isi Ero-Tolliver Source Type: research
