Cardiac metabolic remodelling in chronic kidney disease
Nature Reviews Nephrology, Published online: 30 May 2022; doi:10.1038/s41581-022-00576-xChronic kidney disease is associated with an increased risk of cardiovascular disease, such as heart failure. Here, the authors examine myocardial metabolic remodelling in chronic kidney disease, including changes in energy substrate use, mitochondrial dysfunction and the role of cardiotonic steroids, and discuss potential metabolic therapies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 30, 2022 Category: Urology & Nephrology Authors: Nikayla Patel Muhammad Magdi Yaqoob Dunja Aksentijevic Source Type: research
Continuing kidney care in conflicts
Nature Reviews Nephrology, Published online: 30 May 2022; doi:10.1038/s41581-022-00588-7The devastating effects of war are far-reaching and particularly affect people with kidney disease. The Ukrainian conflict has highlighted problems encountered in the provision of support for this vulnerable group. On the basis of these and previous experiences in massive disasters, we propose a sustainable action plan to prepare for similar logistical challenges in future conflicts. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 30, 2022 Category: Urology & Nephrology Authors: Raymond Vanholder Anja De Weggheleire Dmytro D. Ivanov Valerie Luyckx Slim Slama Mohamed Sekkarie Mehmet S. Sever Rukshana Shroff Source Type: research
Bringing Pride to nephrology
Nature Reviews Nephrology, Published online: 20 May 2022; doi:10.1038/s41581-022-00584-xJune marks Pride Month — an event that aims to recognize and celebrate LGBTQ+ communities worldwide. However, it also provides an opportunity to highlight the challenges that LGBTQ+ colleagues and nephrology patients continue to face, and the need to address health inequities. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 20, 2022 Category: Urology & Nephrology Source Type: research
Interferon blockade in lupus: effects on antiviral immunity
Nature Reviews Nephrology, Published online: 06 May 2022; doi:10.1038/s41581-022-00581-0Targeting type I interferon immune responses is a potential strategy for the treatment of systemic lupus erythematosus. Although a phase 2 clinical trial of anifrolumab did not meet its primary end point, further studies are needed to assess the effects of interferon blockade on flare rates of lupus nephritis. However, the observed higher risk of herpes zoster associated with anifrolumab use suggests that caution is warranted with this strategy. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 6, 2022 Category: Urology & Nephrology Authors: Stefanie Steiger Hans-Joachim Anders Source Type: research
Transcatheter mitral valve repair in patients with CKD
Nature Reviews Nephrology, Published online: 06 May 2022; doi:10.1038/s41581-022-00583-yA post hoc analysis of the COAPT trial suggests that transcatheter mitral valve repair for secondary mitral regurgitation is efficacious in patients with heart failure and chronic kidney disease. The intervention also reduced the risk of kidney failure, raising hypotheses regarding the mechanisms that link heart failure and loss of kidney function. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 6, 2022 Category: Urology & Nephrology Authors: Wendy McCallum Mark J. Sarnak Source Type: research
mTORC1 under the control of CB1R
Nature Reviews Nephrology, Published online: 04 May 2022; doi:10.1038/s41581-022-00582-zmTORC1 under the control of CB1R (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 4, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Our commitment to rigorous, constructive and inclusive peer review
Nature Reviews Nephrology, Published online: 02 May 2022; doi:10.1038/s41581-022-00569-wAt Nature Reviews Nephrology, we believe that peer review should be a rigorous, constructive and inclusive process. We are working to meet this aim through several initiatives. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 2, 2022 Category: Urology & Nephrology Source Type: research
Role of glomerular endothelial cell fenestrations
Nature Reviews Nephrology, Published online: 28 April 2022; doi:10.1038/s41581-022-00577-wRole of glomerular endothelial cell fenestrations (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 28, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Treating mild chronic hypertension in pregnancy
Nature Reviews Nephrology, Published online: 28 April 2022; doi:10.1038/s41581-022-00578-9Treating mild chronic hypertension in pregnancy (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 28, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
NUAK1 promotes kidney fibrosis
Nature Reviews Nephrology, Published online: 28 April 2022; doi:10.1038/s41581-022-00580-1NUAK1 promotes kidney fibrosis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 28, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
METTL3 contributes to the pathogenesis of AKI
Nature Reviews Nephrology, Published online: 28 April 2022; doi:10.1038/s41581-022-00579-8METTL3 contributes to the pathogenesis of AKI (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 28, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Membranous nephropathy: new pathogenic mechanisms and their clinical implications
Nature Reviews Nephrology, Published online: 28 April 2022; doi:10.1038/s41581-022-00564-1Understanding of the pathogenesis of membranous nephropathy has improved substantially, thanks to the discovery of pathogenic circulating autoantibodies against endogenous antigens. This Review provides an overview of the immunological processes involved in the aetiopathogenesis of membranous nephropathy, including loss of immune tolerance, genetic susceptibility factors and the role of autoantibody binding in the kidney. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 28, 2022 Category: Urology & Nephrology Authors: Elion Hoxha Linda Reinhard Rolf A. K. Stahl Source Type: research
Advancing kidney health justice through gender-affirming care
Nature Reviews Nephrology, Published online: 26 April 2022; doi:10.1038/s41581-022-00575-yAdvancing kidney health justice for all requires the kidney-care community to embrace gender-affirming care across the life course, including inclusion of gender minority individuals in research, thoughtful attention to sexual-orientation and gender-identity data collection, as well as the promotion of policies and practices that protect and provide comprehensive care to all patients. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 26, 2022 Category: Urology & Nephrology Authors: Han E. Eckenrode Joseph T. Flynn Dinushika Mohottige Source Type: research
Artificial intelligence-enabled decision support in nephrology
Nature Reviews Nephrology, Published online: 22 April 2022; doi:10.1038/s41581-022-00562-3Emerging evidence suggests that artificial intelligence (AI)-enabled decision support systems may have an important role in the diagnosis, prognosis and treatment of kidney diseases. This Review provides an overview of AI fundamentals and the state of the art of AI-enabled decision support systems in nephrology. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 22, 2022 Category: Urology & Nephrology Authors: Tyler J. Loftus Benjamin Shickel Tezcan Ozrazgat-Baslanti Yuanfang Ren Benjamin S. Glicksberg Jie Cao Karandeep Singh Lili Chan Girish N. Nadkarni Azra Bihorac Source Type: research
Ensuring health equity for sexual and/or gender minority individuals
Nature Reviews Nephrology, Published online: 20 April 2022; doi:10.1038/s41581-022-00572-1People who identify as sexual and/or gender minority individuals face unique and challenging inequities in access to health care. They experience bias, discrimination and underinsurance, which limits their access to high-quality care (including for kidney disease). These inequities must be addressed through the provision of safe and inclusive environments, improved identification of disparities and the creation of a pipeline of equity-focused leaders. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 20, 2022 Category: Urology & Nephrology Authors: Juan D. Salcedo-Betancourt Samira S. Farouk Yuvaram N. V. Reddy Source Type: research
