The fibrogenic niche in kidney fibrosis: components and mechanisms
Nature Reviews Nephrology, Published online: 04 July 2022; doi:10.1038/s41581-022-00590-zThe fibrogenic niche is a unique tissue microenvironment that promotes fibroblast activation in organ fibrosis. This Review discusses the composition, function and mechanisms of action of the fibrogenic niche in kidney fibrosis, as well as the potential implications of the fibrogenic niche hypothesis for the future diagnosis and treatment of kidney diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 4, 2022 Category: Urology & Nephrology Authors: Li Li Haiyan Fu Youhua Liu Source Type: research
Salt substitution: opportunities and challenges for nephrology
Nature Reviews Nephrology, Published online: 24 June 2022; doi:10.1038/s41581-022-00599-4Salt substitution — the partial replacement of sodium with potassium in table salt — is emerging as a powerful public health strategy to reduce hypertension and related diseases. Here, we explore whether salt substitution is suitable for people with kidney disease by weighing the potential cardiorenal benefits against the risk of hyperkalaemia. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 24, 2022 Category: Urology & Nephrology Authors: Ewout J. Hoorn Matti Marklund Jason H. Y. Wu Source Type: research
Role of the cGAS–STING pathway in systemic and organ-specific diseases
Nature Reviews Nephrology, Published online: 22 June 2022; doi:10.1038/s41581-022-00589-6The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway not only is involved in host defence against infection but can lead to immune dysregulation. Here, the authors examine the biology and biochemistry of cGAS–STING and discuss its role in disease and potential approaches to therapeutic targeting. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 22, 2022 Category: Urology & Nephrology Authors: Sladjana Skopelja-Gardner Jie An Keith B. Elkon Source Type: research
The effect of HIF on metabolism and immunity
Nature Reviews Nephrology, Published online: 20 June 2022; doi:10.1038/s41581-022-00587-8Hypoxia-dependent changes in cellular metabolism have important implications for the effective functioning of multiple immune cell subtypes. This Review describes the inputs that shape the hypoxic response in individual cell types and contexts, and the implications of this response for cellular metabolism and associated alterations in immune cell function. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 20, 2022 Category: Urology & Nephrology Authors: Cormac T. Taylor Carsten C. Scholz Source Type: research
Basophils stoke the fire
Nature Reviews Nephrology, Published online: 15 June 2022; doi:10.1038/s41581-022-00597-6Basophils stoke the fire (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 15, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Patient-centred clinical trial design
Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00585-wMeaningful involvement of patients in clinical trial design could lead to improvements in participant recruitment and retention, the uptake of the tested intervention and the impact of the findings. Here, the authors discuss the involvement of patients at all stages of trial design. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 6, 2022 Category: Urology & Nephrology Authors: Allison Tong Nicole Scholes-Robertson Carmel Hawley Andrea K. Viecelli Simon A. Carter Adeera Levin Brenda R. Hemmelgarn Tess Harris Jonathan C. Craig Source Type: research
Benefits of actin cytoskeleton stabilization
Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00596-7Benefits of actin cytoskeleton stabilization (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 6, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Dietary protection of proximal tubules in diabetes
Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00591-yDietary protection of proximal tubules in diabetes (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 6, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Important roles of mechanical force and hydraulic pressure in kidney function
Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00593-wImportant roles of mechanical force and hydraulic pressure in kidney function (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 6, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
P3H2 in glomerular basement membrane regulation
Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00594-9P3H2 in glomerular basement membrane regulation (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 6, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Synchronization in the renal microcirculation
Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00595-8Synchronization in the renal microcirculation (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 6, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Extracellular vesicles in kidney disease
Nature Reviews Nephrology, Published online: 31 May 2022; doi:10.1038/s41581-022-00586-9In this Review, the authors discuss the roles of extracellular vesicles in kidney physiology and disease as well as the beneficial effects of stem cell-derived extracellular vesicles in preclinical models of acute kidney injury and chronic kidney disease. They also highlight current and future clinical applications of extracellular vesicles in kidney diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 31, 2022 Category: Urology & Nephrology Authors: Cristina Grange Benedetta Bussolati Source Type: research
Cardiac metabolic remodelling in chronic kidney disease
Nature Reviews Nephrology, Published online: 30 May 2022; doi:10.1038/s41581-022-00576-xChronic kidney disease is associated with an increased risk of cardiovascular disease, such as heart failure. Here, the authors examine myocardial metabolic remodelling in chronic kidney disease, including changes in energy substrate use, mitochondrial dysfunction and the role of cardiotonic steroids, and discuss potential metabolic therapies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 30, 2022 Category: Urology & Nephrology Authors: Nikayla Patel Muhammad Magdi Yaqoob Dunja Aksentijevic Source Type: research
Continuing kidney care in conflicts
Nature Reviews Nephrology, Published online: 30 May 2022; doi:10.1038/s41581-022-00588-7The devastating effects of war are far-reaching and particularly affect people with kidney disease. The Ukrainian conflict has highlighted problems encountered in the provision of support for this vulnerable group. On the basis of these and previous experiences in massive disasters, we propose a sustainable action plan to prepare for similar logistical challenges in future conflicts. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 30, 2022 Category: Urology & Nephrology Authors: Raymond Vanholder Anja De Weggheleire Dmytro D. Ivanov Valerie Luyckx Slim Slama Mohamed Sekkarie Mehmet S. Sever Rukshana Shroff Source Type: research
Bringing Pride to nephrology
Nature Reviews Nephrology, Published online: 20 May 2022; doi:10.1038/s41581-022-00584-xJune marks Pride Month — an event that aims to recognize and celebrate LGBTQ+ communities worldwide. However, it also provides an opportunity to highlight the challenges that LGBTQ+ colleagues and nephrology patients continue to face, and the need to address health inequities. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 20, 2022 Category: Urology & Nephrology Source Type: research
