Managing RAAS inhibitor use in advanced CKD
Nature Reviews Nephrology, Published online: 30 November 2022; doi:10.1038/s41581-022-00660-2Managing RAAS inhibitor use in advanced CKD (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 30, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Epithelial injury responses in kidney fibrosis
Nature Reviews Nephrology, Published online: 29 November 2022; doi:10.1038/s41581-022-00657-xEpithelial injury responses in kidney fibrosis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 29, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Molecular mechanisms of kidney crosstalk with distant organs
Nature Reviews Nephrology, Published online: 24 November 2022; doi:10.1038/s41581-022-00655-zInter-organ interactions are critical for maintaining homeostasis in the body but can contribute to multi-organ dysfunction. Clinical evidence indicates that kidney dysfunction contributes to remote organ dysfunction, but little is known of the underlying mechanisms. Several reports published in 2022 identified critical mediators of kidney crosstalk with distant organs. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 24, 2022 Category: Urology & Nephrology Authors: Sho Hasegawa Reiko Inagi Source Type: research
Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases
Nature Reviews Nephrology, Published online: 24 November 2022; doi:10.1038/s41581-022-00648-yThis Review discusses the mTORC1 and AMPK nutrient sensing pathways, their downstream effects in kidney cells, their roles in the development of kidney disease and the therapeutic potential of approaches that target these pathways in various chronic kidney diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 24, 2022 Category: Urology & Nephrology Authors: Christopher Huynh Jaewhee Ryu Jooho Lee Ayaka Inoki Ken Inoki Source Type: research
Gut microbiome studies in CKD: opportunities, pitfalls and therapeutic potential
Nature Reviews Nephrology, Published online: 10 November 2022; doi:10.1038/s41581-022-00647-zGut microbiome studies have potential to provide novel therapeutic targets in chronic kidney disease. Here, the authors not only examine the current state of the field and discuss potential gut-related therapies for targeting uraemic metabolites, but also provide guidelines for improving microbiome study design, and data collection and analysis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 10, 2022 Category: Urology & Nephrology Authors: Hubert Krukowski Sophie Valkenburg Avra-Melina Madella Johan Garssen Jeroen van Bergenhenegouwen Saskia Adriana Overbeek Geert R. B. Huys Jeroen Raes Griet Glorieux Source Type: research
Oxalate homeostasis
Nature Reviews Nephrology, Published online: 03 November 2022; doi:10.1038/s41581-022-00643-3Disruptions in oxalate homeostasis can lead to kidney disease and cardiovascular complications. Here, the authors review the pathways that regulate oxalogenesis and the excretion of both exogenous and endogenous oxalate, consider the pathological effects of excess oxalate, and examine the latest therapeutic options for addressing oxalate dysregulation. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 3, 2022 Category: Urology & Nephrology Authors: Theresa Ermer Lama Nazzal Maria Clarissa Tio Sushrut Waikar Peter S. Aronson Felix Knauf Source Type: research
Treatment of SLE with anti-CD19 CAR-T cells
Nature Reviews Nephrology, Published online: 02 November 2022; doi:10.1038/s41581-022-00651-3Treatment of SLE with anti-CD19 CAR-T cells (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 2, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Derivation of collecting duct organoids
Nature Reviews Nephrology, Published online: 02 November 2022; doi:10.1038/s41581-022-00653-1Derivation of collecting duct organoids (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 2, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Long COVID: long-term health outcomes and implications for policy and research
Nature Reviews Nephrology, Published online: 01 November 2022; doi:10.1038/s41581-022-00652-2Long COVID, which refers to post-acute and chronic sequelae of SARS-CoV-2 infection, can affect nearly every organ system and all demographic groups. The high and growing toll of long COVID calls for an urgent need to understand how to prevent and treat it. Governments and health systems must address the care needs of people with long COVID. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 1, 2022 Category: Urology & Nephrology Authors: Ziyad Al-Aly Anupam Agarwal Nisreen Alwan Valerie A. Luyckx Source Type: research
Genetics of posterior urethral valves
Nature Reviews Nephrology, Published online: 01 November 2022; doi:10.1038/s41581-022-00649-xGenetics of posterior urethral valves (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 1, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Youth-onset type 2 diabetes mellitus: an urgent challenge
Nature Reviews Nephrology, Published online: 31 October 2022; doi:10.1038/s41581-022-00645-1This Review describes the global epidemiology, clinical course and key complications of youth-onset type 2 diabetes mellitus. The authors also discuss the mechanisms that might underlie the aggressive clinical phenotype of this disease and current management strategies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 31, 2022 Category: Urology & Nephrology Authors: Petter Bjornstad Lily C. Chao Melanie Cree-Green Allison B. Dart Malcolm King Helen C. Looker Dianna J. Magliano Kristen J. Nadeau Orit Pinhas-Hamiel Amy S. Shah Daniel H. van Raalte Meda E. Pavkov Robert G. Nelson Source Type: research
AngII autoantibodies after SARS-CoV-2 infection
Nature Reviews Nephrology, Published online: 29 October 2022; doi:10.1038/s41581-022-00650-4AngII autoantibodies after SARS-CoV-2 infection (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 29, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
The pathogenesis of pre-eclampsia in kidney donors
Nature Reviews Nephrology, Published online: 27 October 2022; doi:10.1038/s41581-022-00646-0Kidney donation and chronic kidney disease are associated with an increased risk of pre-eclampsia. A recent study in pregnant uninephrectomized mice provides new insights into the mechanisms that underlie these associations and potential therapeutic strategies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 27, 2022 Category: Urology & Nephrology Authors: Giorgina Barbara Piccoli Oralia Alejandra Orozco-Guill én Source Type: research
Advances in CRISPR therapeutics
Nature Reviews Nephrology, Published online: 24 October 2022; doi:10.1038/s41581-022-00636-2This Review focuses on the potential applications of CRISPR to treat diseases that cannot be overcome by inducing frameshifts or premature stops in coding genes. The authors discuss Cas protein engineering and CRISPR systems beyond Cas9 that create a toolbox to engineer the human genome. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 24, 2022 Category: Urology & Nephrology Authors: Michael Chavez Xinyi Chen Paul B. Finn Lei S. Qi Source Type: research
Spatial metabolic tracing in the kidney — the future is now
Nature Reviews Nephrology, Published online: 24 October 2022; doi:10.1038/s41581-022-00644-2A new study used metabolic tracing of the three main carbon sources (glucose, glutamine and lipids) on cultured slices of mouse kidneys to identify the dynamic metabolic changes that occur after injury in different segments of the kidney tubule at the single-cell level. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 24, 2022 Category: Urology & Nephrology Authors: Alessandra Boletta Source Type: research
