Genetics of posterior urethral valves
Nature Reviews Nephrology, Published online: 01 November 2022; doi:10.1038/s41581-022-00649-xGenetics of posterior urethral valves (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 1, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
Youth-onset type 2 diabetes mellitus: an urgent challenge
Nature Reviews Nephrology, Published online: 31 October 2022; doi:10.1038/s41581-022-00645-1This Review describes the global epidemiology, clinical course and key complications of youth-onset type 2 diabetes mellitus. The authors also discuss the mechanisms that might underlie the aggressive clinical phenotype of this disease and current management strategies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 31, 2022 Category: Urology & Nephrology Authors: Petter Bjornstad Lily C. Chao Melanie Cree-Green Allison B. Dart Malcolm King Helen C. Looker Dianna J. Magliano Kristen J. Nadeau Orit Pinhas-Hamiel Amy S. Shah Daniel H. van Raalte Meda E. Pavkov Robert G. Nelson Source Type: research
AngII autoantibodies after SARS-CoV-2 infection
Nature Reviews Nephrology, Published online: 29 October 2022; doi:10.1038/s41581-022-00650-4AngII autoantibodies after SARS-CoV-2 infection (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 29, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
The pathogenesis of pre-eclampsia in kidney donors
Nature Reviews Nephrology, Published online: 27 October 2022; doi:10.1038/s41581-022-00646-0Kidney donation and chronic kidney disease are associated with an increased risk of pre-eclampsia. A recent study in pregnant uninephrectomized mice provides new insights into the mechanisms that underlie these associations and potential therapeutic strategies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 27, 2022 Category: Urology & Nephrology Authors: Giorgina Barbara Piccoli Oralia Alejandra Orozco-Guill én Source Type: research
Advances in CRISPR therapeutics
Nature Reviews Nephrology, Published online: 24 October 2022; doi:10.1038/s41581-022-00636-2This Review focuses on the potential applications of CRISPR to treat diseases that cannot be overcome by inducing frameshifts or premature stops in coding genes. The authors discuss Cas protein engineering and CRISPR systems beyond Cas9 that create a toolbox to engineer the human genome. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 24, 2022 Category: Urology & Nephrology Authors: Michael Chavez Xinyi Chen Paul B. Finn Lei S. Qi Source Type: research
Spatial metabolic tracing in the kidney — the future is now
Nature Reviews Nephrology, Published online: 24 October 2022; doi:10.1038/s41581-022-00644-2A new study used metabolic tracing of the three main carbon sources (glucose, glutamine and lipids) on cultured slices of mouse kidneys to identify the dynamic metabolic changes that occur after injury in different segments of the kidney tubule at the single-cell level. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 24, 2022 Category: Urology & Nephrology Authors: Alessandra Boletta Source Type: research
Trained immunity — basic concepts and contributions to immunopathology
Nature Reviews Nephrology, Published online: 17 October 2022; doi:10.1038/s41581-022-00633-5Trained immunity refers to the development of immunological memory in innate immune cells. Here, the authors examine the basic features of trained immunity, as well as its role and potential therapeutic targeting in immunopathologies that involve the kidney. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 17, 2022 Category: Urology & Nephrology Authors: Jordi Ochando Willem J. M. Mulder Joren C. Madsen Mihai G. Netea Rapha ël Duivenvoorden Source Type: research
Therapeutic advances in COVID-19
Nature Reviews Nephrology, Published online: 17 October 2022; doi:10.1038/s41581-022-00642-4The COVID-19 pandemic was met with large-scale efforts to assess novel and repurposed therapeutic interventions that could reduce patient morbidity and mortality. Here, the authors discuss the different types of therapies available to treat COVID-19, including their relevance to patients with kidney failure and kidney transplant recipients. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 17, 2022 Category: Urology & Nephrology Authors: Naoka Murakami Robert Hayden Thomas Hills Hanny Al-Samkari Jonathan Casey Lorenzo Del Sorbo Patrick R. Lawler Meghan E. Sise David E. Leaf Source Type: research
Cisplatin nephrotoxicity: new insights and therapeutic implications
Nature Reviews Nephrology, Published online: 13 October 2022; doi:10.1038/s41581-022-00631-7Here, the authors review the mechanisms that underlie cisplatin-induced acute kidney injury and chronic kidney disease. They also discuss the challenges of developing renoprotective approaches for patients receiving cisplatin-based chemotherapy and potential targets for renoprotection. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 13, 2022 Category: Urology & Nephrology Authors: Chengyuan Tang Man J. Livingston Robert Safirstein Zheng Dong Source Type: research
Progress in xenotransplantation: overcoming immune barriers
Nature Reviews Nephrology, Published online: 05 October 2022; doi:10.1038/s41581-022-00624-6This Review summarizes the current state of knowledge regarding immunological barriers to xenotransplantation and discusses the major approaches that are being used to overcome these barriers, including immunosuppression, genetic engineering of pigs and tolerance induction. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 5, 2022 Category: Urology & Nephrology Authors: Megan Sykes David H. Sachs Source Type: research
Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury
Nature Reviews Nephrology, Published online: 27 September 2022; doi:10.1038/s41581-022-00630-8Immune checkpoint inhibitors are increasingly used as anti-cancer treatments; however, their use can be associated with the development of immune-related adverse events, including acute kidney injury. This Review describes the symptoms, biochemical signs and possible underlying mechanisms of immune checkpoint inhibitor-associated acute kidney injury, and proposes an approach to its diagnosis and management. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 27, 2022 Category: Urology & Nephrology Authors: Ben Sprangers David E. Leaf Camillo Porta Maria Jos é Soler Mark A. Perazella Source Type: research
De-repression of Pkd1 or Pkd2 attenuates ADPKD
Nature Reviews Nephrology, Published online: 23 September 2022; doi:10.1038/s41581-022-00640-6De-repression of Pkd1 or Pkd2 attenuates ADPKD (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 23, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
A UMOD variant with intermediate effects
Nature Reviews Nephrology, Published online: 23 September 2022; doi:10.1038/s41581-022-00638-0A UMOD variant with intermediate effects (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 23, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Increased PD1 signalling in kidney ageing
Nature Reviews Nephrology, Published online: 23 September 2022; doi:10.1038/s41581-022-00641-5Increased PD1 signalling in kidney ageing (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 23, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Removal of small, asymptomatic kidney stones
Nature Reviews Nephrology, Published online: 23 September 2022; doi:10.1038/s41581-022-00639-zRemoval of small, asymptomatic kidney stones (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 23, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
