In vivo slit diaphragm dynamics in Drosophila
Nature Reviews Nephrology, Published online: 26 August 2022; doi:10.1038/s41581-022-00626-4In vivo slit diaphragm dynamics in Drosophila (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 26, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
YAP and TAZ regulate stromal cell development
Nature Reviews Nephrology, Published online: 26 August 2022; doi:10.1038/s41581-022-00628-2YAP and TAZ regulate stromal cell development (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 26, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Leveraging lysine metabolism for renoprotection
Nature Reviews Nephrology, Published online: 26 August 2022; doi:10.1038/s41581-022-00625-5Leveraging lysine metabolism for renoprotection (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 26, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
NCKs are essential to podocyte–GBM interactions
Nature Reviews Nephrology, Published online: 26 August 2022; doi:10.1038/s41581-022-00627-3NCKs are essential to podocyte–GBM interactions (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 26, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions
Nature Reviews Nephrology, Published online: 24 August 2022; doi:10.1038/s41581-022-00618-4In this Review, the authors summarize the challenges associated with the care of patients with kidney disease during the COVID-19 pandemic. They describe the major challenges and missed opportunities, global inequalities in health care, and offer a framework for future pandemic preparedness. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 24, 2022 Category: Urology & Nephrology Authors: Duvuru Geetha Andreas Kronbichler Megan Rutter Divya Bajpai Steven Menez Annemarie Weissenbacher Shuchi Anand Eugene Lin Nicholas Carlson Stephen Sozio Kevin Fowler Ray Bignall Kathryn Ducharlet Elliot K. Tannor Eranga Wijewickrama Muhammad I. A. Hafiz Vl Source Type: research
Vaccination in patients with kidney failure: lessons from COVID-19
Nature Reviews Nephrology, Published online: 23 August 2022; doi:10.1038/s41581-022-00617-5Effective vaccination strategies are crucial to mitigate the high risk of infection-associated morbidity and mortality in patients with kidney failure. Here, the authors examine vaccine-induced immunity in these patients, in particular their responses to COVID-19 vaccination, in the context of the immune impairment induced by kidney dysfunction and the use of immunosuppressive medications. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 23, 2022 Category: Urology & Nephrology Authors: Nina Babel Christian Hugo Timm H. Westhoff Source Type: research
Electronic patient-reported outcomes in chronic kidney disease
Nature Reviews Nephrology, Published online: 22 August 2022; doi:10.1038/s41581-022-00619-3Considerable research and investment have focused on the use of electronic patient-reported outcomes (ePROs) in nephrology. However, systematic collection of ePROs to inform the care of patients with chronic kidney disease remains sporadic. A change in culture is needed to encourage their wider adoption in clinical practice. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 22, 2022 Category: Urology & Nephrology Authors: Nicola Anderson Derek Kyte Christel McMullan Paul Cockwell Olalekan L. Aiyegbusi Ravinder Verdi Melanie J. Calvert Source Type: research
MicroRNAs in kidney injury and disease
Nature Reviews Nephrology, Published online: 16 August 2022; doi:10.1038/s41581-022-00608-6In this Review, the authors provide an overview of the roles of miRNAs in the development of chronic kidney disease, acute kidney injury and allograft injury. They also discuss the utilization of miRNAs as biomarkers and their potential as therapeutic targets in kidney disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 16, 2022 Category: Urology & Nephrology Authors: Nassim Mahtal Olivia Lenoir Claire Tinel Dany Anglicheau Pierre-Louis Tharaux Source Type: research
A polygenic score predicts CKD across ancestries
Nature Reviews Nephrology, Published online: 11 August 2022; doi:10.1038/s41581-022-00622-8Chronic kidney disease (CKD) is often well advanced before it is detected. Although polygenic scores may enable the early stratification of patients at risk of CKD, the transferability of polygenic scores for the prediction of CKD to populations of non-European ancestry was limited. A new cross-ancestry polygenic score for CKD overcomes these issues, demonstrating good performance across ancestries. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 11, 2022 Category: Urology & Nephrology Authors: Inga Steinbrenner Anna K öttgen Source Type: research
Cellular senescence: the good, the bad and the unknown
Nature Reviews Nephrology, Published online: 03 August 2022; doi:10.1038/s41581-022-00601-zCellular senescence has beneficial functions in embryonic development, wound healing and tumour suppression but can also be maladaptive, contributing to cancer development and disease. This Review describes the mechanisms, hallmarks and consequences of senescence, as well as the therapeutic potential of senescence-targeting interventions. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 3, 2022 Category: Urology & Nephrology Authors: Weijun Huang LaTonya J. Hickson Alfonso Eirin James L. Kirkland Lilach O. Lerman Source Type: research
Kidney disease as a medical complication of eating disorders
Nature Reviews Nephrology, Published online: 02 August 2022; doi:10.1038/s41581-022-00610-yKidney disease is an underappreciated medical complication of anorexia nervosa. Further research is needed to clarify the mechanisms that drive kidney disease in patients who restrict caloric intake or engage in purging. Education and awareness are also needed, because kidney disease is often under-recognized by these patients and their clinicians. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 2, 2022 Category: Urology & Nephrology Authors: Leah Puckett Shoshana Mehler Philip Mehler Source Type: research
A pathway of osmotic stress-induced necroptosis
Nature Reviews Nephrology, Published online: 01 August 2022; doi:10.1038/s41581-022-00607-7Necroptosis is a form of regulated necrosis in which RIPK3 is activated by binding to RIP homotypic interaction motif (RHIM)-containing proteins. Now, researchers describe a non-canonical pathway of RIPK3 activation that is triggered by osmotic stress and NHE1-mediated cytosol alkalinization. This previously undescribed mechanism of osmotic stress-induced necroptosis might have implications for treating cancer and other diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 1, 2022 Category: Urology & Nephrology Authors: Alberto Ortiz Ana B. Sanz Source Type: research
Restrictive fluid therapy and high-dose vitamin C in sepsis
Nature Reviews Nephrology, Published online: 01 August 2022; doi:10.1038/s41581-022-00609-5Two recent randomized trials provide evidence to guide the management of sepsis. The CLASSIC trial reports that restrictive fluid therapy has no mortality benefit compared to a standard regimen in patients with septic shock, whereas the LOVIT trial reports that high-dose intravenous vitamin C might be harmful in patients with severe sepsis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 1, 2022 Category: Urology & Nephrology Authors: Mark Philip Plummer Rinaldo Bellomo Source Type: research
Pervasive kidney health inequities for Māori require multi-level attention
Nature Reviews Nephrology, Published online: 29 July 2022; doi:10.1038/s41581-022-00606-8Indigenous Māori experience inequitably high rates of kidney failure and lower rates of kidney transplant, pre-emptive procedures and home dialysis when compared to the New Zealand population as a whole. Prevention strategies in primary care, cultural safety training and routine clinical audit for renal practitioners alongside Indigenous people in governance, management and the clinical workforce would greatly improve Māori outcomes. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 29, 2022 Category: Urology & Nephrology Authors: David Tipene-Leach Rachael Walker Source Type: research
Activation and regulation of alloreactive T cell immunity in solid organ transplantation
Nature Reviews Nephrology, Published online: 27 July 2022; doi:10.1038/s41581-022-00600-0Alloimmune T cell responses have a crucial role in graft rejection. Here, the authors examine the factors that regulate T cell activation, differentiation and function in secondary lymphoid organs and in the graft, including the different pathways of allorecognition, innate–adaptive immunity crosstalk and the role of survival cytokines. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 27, 2022 Category: Urology & Nephrology Authors: Charlotte Duneton Pamela D. Winterberg Mandy L. Ford Source Type: research
