Mechanisms of hypoxia signalling: new implications for nephrology
Nature Reviews Nephrology, Published online: 05 September 2019; doi:10.1038/s41581-019-0182-zTherapeutic modulation of hypoxia-inducible factors, which transduce adaptive transcriptional responses to hypoxia, is an emerging theme in kidney disease. This Review summarizes the hypoxia signalling mechanisms underpinning these novel treatments and highlights key remaining questions relevant to their clinical use. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 5, 2019 Category: Urology & Nephrology Authors: Johannes Sch ödel Peter J. Ratcliffe Source Type: research

The pathobiology of polycystic kidney disease from a metabolic viewpoint
Nature Reviews Nephrology, Published online: 05 September 2019; doi:10.1038/s41581-019-0183-yIncreasing evidence suggests that dysregulation of cellular metabolism has a role in the pathophysiology of autosomal dominant polycystic kidney disease. Here the authors discuss the underlying pathways and review efforts to use pharmacological interventions and lifestyle modifications to slow disease progression. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 5, 2019 Category: Urology & Nephrology Authors: Luis Fernando Menezes Gregory G. Germino Source Type: research

Tolerogenic cell therapy for glomerulonephritis
Nature Reviews Nephrology, Published online: 03 September 2019; doi:10.1038/s41581-019-0206-8Tolerogenic cell therapy for glomerulonephritis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 3, 2019 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

PAX8: a candidate oncogene in RCC
Nature Reviews Nephrology, Published online: 03 September 2019; doi:10.1038/s41581-019-0205-9PAX8: a candidate oncogene in RCC (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 3, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Disparities between trial cohorts and real-life patients
Nature Reviews Nephrology, Published online: 02 September 2019; doi:10.1038/s41581-019-0202-zA new study reports important differences between the characteristics of patients with end-stage renal disease on dialysis who are enrolled in clinical trials worldwide and the general US dialysis population. These findings highlight the importance of including older patients and those with comorbidities in clinical trials. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 2, 2019 Category: Urology & Nephrology Authors: Andrew Davenport Source Type: research

Immunology of the ageing kidney
Nature Reviews Nephrology, Published online: 02 September 2019; doi:10.1038/s41581-019-0185-9Immunological ageing has profound effects on the immune system and its ability to protect the host against infection, cancer and autoimmunity. In this Review, the authors discuss how the processes of immunosenescence and inflammageing drive these age-related changes, and their effects on the ageing kidney. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 2, 2019 Category: Urology & Nephrology Authors: Yuki Sato Motoko Yanagita Source Type: research

Lipid lowering and risk of haemorrhagic stroke in CKD
Nature Reviews Nephrology, Published online: 29 August 2019; doi:10.1038/s41581-019-0201-0Haemorrhagic stroke is more common in adults with chronic kidney disease (CKD) than in the general population. A recent study reports that low concentrations of LDL significantly increase the risk of haemorrhagic stroke. This finding challenges the concept of aggressive lipid lowering in patients with high cardiovascular risk, including those with CKD. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 29, 2019 Category: Urology & Nephrology Authors: Steven Van Laecke Source Type: research

Mechanisms of haemolysis-induced kidney injury
Nature Reviews Nephrology, Published online: 27 August 2019; doi:10.1038/s41581-019-0181-0Intravascular haemolysis and the subsequent release of proinflammatory haemoglobin and haem into the circulation are characteristic of several diseases. This Review discusses the major pathophysiological mechanisms and consequences of intravascular haemolysis with a focus on the kidney, and highlights emerging therapeutic strategies to target haemolysis-related kidney injury. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 27, 2019 Category: Urology & Nephrology Authors: Kristof Van Avondt Erfan Nur Sacha Zeerleder Source Type: research

MENTOR heralds a new era of therapy for membranous nephropathy
Nature Reviews Nephrology, Published online: 23 August 2019; doi:10.1038/s41581-019-0200-1The MENTOR trial reported that rituximab is superior to ciclosporin for remission of nephrotic syndrome in patients with membranous nephropathy. Rituximab is better tolerated than other treatments but, as up to 40% of patients did not respond to rituximab, alternative immunosuppressive therapies may still be required for a substantial minority of patients. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 23, 2019 Category: Urology & Nephrology Authors: Aikaterini Nikolopoulou Megan Griffith Source Type: research

Molecular nephrology: types of acute tubular injury
Nature Reviews Nephrology, Published online: 22 August 2019; doi:10.1038/s41581-019-0184-xAcute kidney injury (AKI) is diagnosed by the serum concentration of creatinine (SCr), an insensitive marker of kidney function. The authors of this Review discuss the properties of ideal biomarkers of tubular damage and how they can be combined with SCr-based AKI definitions to provide greater insights into the processes underlying acute tubular injury. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 22, 2019 Category: Urology & Nephrology Authors: Beatriz Desanti De Oliveira Katherine Xu Tian H. Shen Miriam Callahan Krzysztof Kiryluk Vivette D. D ’Agati Nicholas P. Tatonetti Jonathan Barasch Prasad Devarajan Source Type: research

The path to open data
Nature Reviews Nephrology, Published online: 19 August 2019; doi:10.1038/s41581-019-0188-6The increasing volumes of biological and clinical data have the potential to greatly enhance our understanding of the processes underlying kidney function and disease. However, maximizing outputs from these data requires a collaborative and open approach to data sharing that can only be achieved through united efforts by researchers, funders and publishers. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 19, 2019 Category: Urology & Nephrology Source Type: research

Lipids mediate podocyte damage
Nature Reviews Nephrology, Published online: 09 August 2019; doi:10.1038/s41581-019-0196-6Lipids mediate podocyte damage (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 9, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

CD9 boosts PEC glomerular invasion
Nature Reviews Nephrology, Published online: 09 August 2019; doi:10.1038/s41581-019-0198-4CD9 boosts PEC glomerular invasion (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 9, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis
Nature Reviews Nephrology, Published online: 09 August 2019; doi:10.1038/s41581-019-0178-8Staphylococcus infection-associated glomerulonephritis (SAGN) and acute post-streptococcal glomerulonephritis (APSGN) are the two main types of bacterial infection-associated glomerulonephritis. In this Review, the authors discuss the epidemiology of these diseases, common histopathology findings and the complexities of clinical diagnosis, as well as patient management and renal outcomes. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 9, 2019 Category: Urology & Nephrology Authors: Anjali A. Satoskar Samir V. Parikh Tibor Nadasdy Source Type: research

Remote sensing and signalling in the kidney controls microbial metabolite levels
Nature Reviews Nephrology, Published online: 08 August 2019; doi:10.1038/s41581-019-0195-7Remote sensing and signalling in the kidney controls microbial metabolite levels (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 8, 2019 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Aspirnaut: a rural high school pipeline to increase diversity in STEM
Nature Reviews Nephrology, Published online: 08 August 2019; doi:10.1038/s41581-019-0190-zA critical need exists for innovations in education that increase the recruitment of high school students from diverse backgrounds into the biomedical research workforce. Aspirnaut is one model that addresses this challenge. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 8, 2019 Category: Urology & Nephrology Authors: Julie K. Hudson Billy G. Hudson Source Type: research

New insights into energy and protein homeostasis by the kidney
Nature Reviews Nephrology, Published online: 06 August 2019; doi:10.1038/s41581-019-0192-xUnderstanding of the cardinal role of the kidneys in maintaining fluid and electrolyte homeostasis is deeply rooted in nephrology. However, the fact that the kidney regulates protein and energy homeostasis similarly to the liver has long been overlooked. Comprehensive whole-body metabolomics studies now shed light on this important aspect of kidney function. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 6, 2019 Category: Urology & Nephrology Authors: Ton J. Rabelink Martin Giera Source Type: research

Study of ADTKD-MUC1 identifies a new lead for the treatment of toxic proteinopathies
Nature Reviews Nephrology, Published online: 06 August 2019; doi:10.1038/s41581-019-0194-8Study of ADTKD-MUC1 identifies a new lead for the treatment of toxic proteinopathies (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 6, 2019 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Human kidney organoids: progress and remaining challenges
Nature Reviews Nephrology, Published online: 05 August 2019; doi:10.1038/s41581-019-0176-xKidney organoids have the potential to advance the field of nephrology. Here, the author discusses progress in the development of kidney organoids and describes remaining challenges to the use of these cultures for the study of kidney physiology and disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 5, 2019 Category: Urology & Nephrology Authors: Ryuichi Nishinakamura Source Type: research

IL-6-dependent regulatory T cells in GN
Nature Reviews Nephrology, Published online: 05 August 2019; doi:10.1038/s41581-019-0193-9IL-6-dependent regulatory T cells in GN (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 5, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Crystals spoil mitochondrial potential
Nature Reviews Nephrology, Published online: 02 August 2019; doi:10.1038/s41581-019-0187-7Crystals spoil mitochondrial potential (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 2, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Author Correction: Using and producing publicly available genomic data to accelerate discovery in nephrology
Nature Reviews Nephrology, Published online: 30 July 2019; doi:10.1038/s41581-019-0186-8Author Correction: Using and producing publicly available genomic data to accelerate discovery in nephrology (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 30, 2019 Category: Urology & Nephrology Authors: Matthew G. Sampson Hyun Min Kang Source Type: research

The case for uric acid-lowering treatment in patients with hyperuricaemia and CKD
Nature Reviews Nephrology, Published online: 11 July 2019; doi:10.1038/s41581-019-0174-zThis Perspectives article considers why clinical trials of urate-lowering therapy (ULT) have shown inconsistent renoprotective effects in patients with chronic kidney disease, and suggests that sufficient evidence exists to support the use of routine screening for hyperuricaemia and initiation of ULT in selected patients. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 11, 2019 Category: Urology & Nephrology Authors: Yuka Sato Daniel I. Feig Austin G. Stack Duk-Hee Kang Miguel A. Lanaspa A. Ahsan Ejaz L. Gabriela S ánchez-Lozada Masanari Kuwabara Claudio Borghi Richard J. Johnson Source Type: research

ER calcium stabilizers in NS
Nature Reviews Nephrology, Published online: 10 July 2019; doi:10.1038/s41581-019-0180-1ER calcium stabilizers in NS (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 10, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Gene signatures reveal kidney immune cells
Nature Reviews Nephrology, Published online: 08 July 2019; doi:10.1038/s41581-019-0179-7Gene signatures reveal kidney immune cells (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 8, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

A single-cell, 2D atlas of the normal human kidney using imaging mass cytometry
Nature Reviews Nephrology, Published online: 02 July 2019; doi:10.1038/s41581-019-0177-9A single-cell, 2D atlas of the normal human kidney using imaging mass cytometry (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 2, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Histocompatibility: minor differences have a major impact
Nature Reviews Nephrology, Published online: 28 June 2019; doi:10.1038/s41581-019-0175-yThe clinical relevance of minor histocompatibility antigens in transplantation is disputed. High-throughput approaches are now being used to investigate the role of genome-wide genetic incompatibility in transplant outcomes. A recent study reports that donor and recipient mismatch at the LIMS1 locus is associated with an increased risk of acute rejection. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 28, 2019 Category: Urology & Nephrology Authors: Roman Reindl-Schwaighofer Rainer Oberbauer Source Type: research

Intestinal microbiome and fitness in kidney disease
Nature Reviews Nephrology, Published online: 26 June 2019; doi:10.1038/s41581-019-0172-1The microbiome is increasingly recognized as an element that contributes to health and disease. Here, the authors take an ecological approach to describe the impact of factors related to chronic kidney disease on the fitness of different physiological systems and the effects of these changes on microbiota composition. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 26, 2019 Category: Urology & Nephrology Authors: Bj örn Meijers Pieter Evenepoel Hans-Joachim Anders Source Type: research

The role of sodium in modulating immune cell function
Nature Reviews Nephrology, Published online: 25 June 2019; doi:10.1038/s41581-019-0167-ySodium has a crucial role in osmoregulation and fluid balance. In this Review, the authors discuss how sodium is also an important functional modulator of innate and adaptive immune cells and how it might be linked to chronic inflammatory conditions. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 25, 2019 Category: Urology & Nephrology Authors: Nicola Wilck Andr ás Balogh Lajos Mark ó Hendrik Bartolomaeus Dominik N. M üller Source Type: research

CREDENCE and DELIGHT deliver on renal benefits
Nature Reviews Nephrology, Published online: 25 June 2019; doi:10.1038/s41581-019-0171-2Inhibitors of sodium–glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase 4 (DPP4) are widely used in patients with type 2 diabetes to improve glycaemic control and reduce cardiovascular risks. Two recent clinical trials, CREDENCE and DELIGHT, demonstrate that these drugs can also slow down the progression of kidney disease in these patients. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 25, 2019 Category: Urology & Nephrology Authors: Christoph Wanner Susanne Brenner Source Type: research

Considerations for SGLT2 inhibitor use in post-transplantation diabetes
Nature Reviews Nephrology, Published online: 24 June 2019; doi:10.1038/s41581-019-0173-0Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been recommended for the treatment of patients with type 2 diabetes mellitus and cardiovascular disease, heart failure or chronic kidney disease. Findings from recent efficacy and safety trials of empagliflozin in kidney transplant recipients with post-transplantation diabetes are timely, given the elevated cardiovascular risk associated with solid organ transplantation. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 24, 2019 Category: Urology & Nephrology Authors: Manfred Hecking Trond Jenssen Source Type: research

SONAR propels endothelin A receptor antagonists to success
This study was designed to select patients who were likely to benefit from the therapy and minimize the risk of adverse effects. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 19, 2019 Category: Urology & Nephrology Authors: Jennifer S. Pollock David M. Pollock Source Type: research

Extracellular DNA traps in inflammation, injury and healing
Nature Reviews Nephrology, Published online: 18 June 2019; doi:10.1038/s41581-019-0163-2Various cell types release extracellular DNA traps that protect the host against microbial infections. In this Review, the authors discuss how DNA traps not only participate in pathogen clearance but can also promote vascular disease and autoimmunity. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 18, 2019 Category: Urology & Nephrology Authors: Christoph Daniel Moritz Leppkes Luis E. Mu ñoz Gunnar Schley Georg Schett Martin Herrmann Source Type: research

A million genotypes to find CKD-linked loci
Nature Reviews Nephrology, Published online: 14 June 2019; doi:10.1038/s41581-019-0170-3A million genotypes to find CKD-linked loci (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 14, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease
Nature Reviews Nephrology, Published online: 13 June 2019; doi:10.1038/s41581-019-0161-4This Evidence-Based Guideline developed by members of the European Society for Paediatric Nephrology CKD-MBD, Dialysis and Transplantation working groups presents clinical practice recommendations for the use of growth hormone in children with chronic kidney disease on dialysis and after renal transplantation. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 13, 2019 Category: Urology & Nephrology Authors: Jens Drube Mandy Wan Marjolein Bonthuis Elke W ühl Justine Bacchetta Fernando Santos Ryszard Grenda Alberto Edefonti Jerome Harambat Rukshana Shroff Burkhard T önshoff Dieter Haffner Source Type: research

Nephropathic autoantigens in the spectrum of lupus nephritis
Nature Reviews Nephrology, Published online: 13 June 2019; doi:10.1038/s41581-019-0168-xIn a collaborative effort, researchers have identified unusual protein deposits of exostosin 1 and exostosin 2 in patients with PLA2R and THSD7A-negative membranous nephropathy, many of whom had systemic lupus erythematosus, lupus nephritis or other forms of autoimmunity. Although serum exostosin antibodies were not detected, the findings suggest that these proteins could define a distinct subtype of membranous nephropathy. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 13, 2019 Category: Urology & Nephrology Authors: Hans-Joachim Anders Source Type: research

Using and producing publicly available genomic data to accelerate discovery in nephrology
Nature Reviews Nephrology, Published online: 10 June 2019; doi:10.1038/s41581-019-0166-zTo advance kidney discovery, our community is driven to maximize the utility of genomic data that we all generate. We can best accomplish this through excellence in appropriately incorporating publicly available genomic data into our research efforts and by enthusiastically embracing widespread data sharing in a manner that facilitates its broad use. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 10, 2019 Category: Urology & Nephrology Authors: Matthew G. Sampson Hyun Min Kang Source Type: research

Mechanisms of phosphate transport
Nature Reviews Nephrology, Published online: 05 June 2019; doi:10.1038/s41581-019-0159-yThis Review describes the mechanisms by which dietary, hormonal and metabolic factors regulate the expression and function of sodium-dependent phosphate cotransporters. The authors discuss the consequences of dysregulated phosphate transport and how understanding of the structure–function relationships of the transporters provides insights into their transport mechanisms. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 5, 2019 Category: Urology & Nephrology Authors: Moshe Levi Enrico Gratton Ian C. Forster Nati Hernando Carsten A. Wagner Juerg Biber Victor Sorribas Heini Murer Source Type: research

A molecular imaging approach for the early, real-time diagnosis of acute kidney injury
Nature Reviews Nephrology, Published online: 05 June 2019; doi:10.1038/s41581-019-0165-0A molecular imaging approach for the early, real-time diagnosis of acute kidney injury (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 5, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Single-cell analysis identifies key pathways and prognostic markers in lupus nephritis
Nature Reviews Nephrology, Published online: 04 June 2019; doi:10.1038/s41581-019-0164-1Single-cell analysis identifies key pathways and prognostic markers in lupus nephritis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 4, 2019 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

The (pro)renin receptor in health and disease
Nature Reviews Nephrology, Published online: 04 June 2019; doi:10.1038/s41581-019-0160-5Here, the authors discuss the multiple functions of the (pro)renin receptor in physiological processes, including blood pressure regulation, energy metabolism and autophagy, as well as its roles in the pathogenesis of diseases including fibrosis, chronic kidney disease, pre-eclampsia and cancer. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 4, 2019 Category: Urology & Nephrology Authors: Atsuhiro Ichihara Midori Sasaki Yatabe Source Type: research

The role of inflammasomes in kidney disease
Nature Reviews Nephrology, Published online: 04 June 2019; doi:10.1038/s41581-019-0158-zIn this Review, the authors discuss the biology of canonical and non-canonical inflammasomes and inflammasome-forming genes in the kidney, including their different functions in the various kidney compartments and their potential as therapeutic targets. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 4, 2019 Category: Urology & Nephrology Authors: Takanori Komada Daniel A. Muruve Source Type: research

International consensus statement on the diagnosis and management of autosomal dominant polycystic kidney disease in children and young people
Nature Reviews Nephrology, Published online: 22 May 2019; doi:10.1038/s41581-019-0155-2This Consensus Statement developed on behalf of the Network for Early Onset Cystic Kidney Disease provides guidance on counselling, diagnosing and monitoring children with autosomal dominant polycystic kidney disease based on current evidence and a multi-stakeholder discussion of ethical issues. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 22, 2019 Category: Urology & Nephrology Authors: Charlotte Gimpel Carsten Bergmann Detlef Bockenhauer Luc Breysem Melissa A. Cadnapaphornchai Metin Cetiner Jan Dudley Francesco Emma Martin Konrad Tess Harris Peter C. Harris Jens K önig Max C. Liebau Matko Marlais Djalila Mekahli Alison M. Metcalfe Jun Source Type: research

PC2–mitochondria interactions in PKD
Nature Reviews Nephrology, Published online: 22 May 2019; doi:10.1038/s41581-019-0162-3PC2–mitochondria interactions in PKD (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 22, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Antimicrobial resistance in nephrology
Antimicrobial resistance in nephrology, Published online: 13 May 2019; doi:10.1038/s41581-019-0150-7Antimicrobial resistance is an emergent global problem and patients with chronic kidney disease have some of the highest rates of colonization and infection with antibiotic-resistant bacteria (ARB). This Review focuses on the epidemiology, prevention and treatment of infections with ARB. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 13, 2019 Category: Urology & Nephrology Authors: Tina Z. Wang Rosy Priya L. Kodiyanplakkal David P. Calfee Source Type: research

Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia
Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia, Published online: 08 May 2019; doi:10.1038/s41581-019-0152-5In this Evidence-Based Guideline on X-linked hypophosphataemia, the authors identify the criteria for diagnosis of this disease, provide guidance for medical and surgical treatment and explain the challenges of follow-up. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 8, 2019 Category: Urology & Nephrology Authors: Dieter Haffner Francesco Emma Deborah M. Eastwood Martin Biosse Duplan Justine Bacchetta Dirk Schnabel Philippe Wicart Detlef Bockenhauer Fernando Santos Elena Levtchenko Pol Harvengt Martha Kirchhoff Federico Di Rocco Catherine Chaussain Maria Louisa Bra Source Type: research

Author Correction: Pre-eclampsia: pathogenesis, novel diagnostics and therapies
Author Correction: Pre-eclampsia: pathogenesis, novel diagnostics and therapies, Published online: 08 May 2019; doi:10.1038/s41581-019-0156-1Author Correction: Pre-eclampsia: pathogenesis, novel diagnostics and therapies (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 8, 2019 Category: Urology & Nephrology Authors: Elizabeth A. Phipps Ravi Thadhani Thomas Benzing S. Ananth Karumanchi Source Type: research

A signature of inflammatory proteins associated with ESRD in diabetes
A signature of inflammatory proteins associated with ESRD in diabetes, Published online: 03 May 2019; doi:10.1038/s41581-019-0157-0A signature of inflammatory proteins associated with ESRD in diabetes (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 3, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Cardiovascular disease in young adults with incident ESRD
Cardiovascular disease in young adults with incident ESRD, Published online: 01 May 2019; doi:10.1038/s41581-019-0154-3Cardiovascular disease (CVD) is a leading cause of death in young adults with incident end-stage renal disease (ESRD). Unlike children with ESRD, young adults with incident ESRD have high prevalence of diabetes, coronary artery disease and heart failure. These cardiovascular risk factors are associated with increased CVD-related hospitalizations and mortality in young adults. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 1, 2019 Category: Urology & Nephrology Authors: Elaine Ku Mark M. Mitsnefes Source Type: research

The ubiquitin–proteasome system in kidney physiology and disease
The ubiquitin–proteasome system in kidney physiology and diseaseThe ubiquitin–proteasome system in kidney physiology and disease, Published online: 29 April 2019; doi:10.1038/s41581-019-0148-1The ubiquitin–proteasome system (UPS) maintains protein homeostasis through the selective degradation of proteins. In addition to degrading short-lived and misfolded proteins, the UPS regulates a multitude of cellular processes, including gene transcription and translation, cell survival and metabolism, and inflammation. This Review provides an overview of UPS-mediated proteostasis, focusing on the involvem...
Source: Nature Reviews Nephrology - April 29, 2019 Category: Urology & Nephrology Authors: Catherine Meyer-Schwesinger Source Type: research