Clinical practice recommendations for primary hyperoxaluria: an expert consensus statement from ERKNet and OxalEurope
Nature Reviews Nephrology, Published online: 05 January 2023; doi:10.1038/s41581-022-00661-1Primary hyperoxaluria is an inherited disorder that results from the overproduction of endogenous oxalate, leading to recurrent kidney stones, nephrocalcinosis, kidney failure and life-threatening systemic disease. This Consensus Statement from ERKNet and OxalEurope provides recommendations for the management of primary hyperoxaluria, including consideration of conventional therapies, new therapies and recommendations for patient follow-up. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 5, 2023 Category: Urology & Nephrology Authors: Jaap W. Groothoff Ella Metry Lisa Deesker Sander Garrelfs Cecile Acquaviva Reham Almardini Bodo B. Beck Olivia Boyer Rimante Cerkauskiene Pietro Manuel Ferraro Luitzen A. Groen Asheeta Gupta Bertrand Knebelmann Giorgia Mandrile Shabbir S. Moochhala Agnies Source Type: research
Gasdermins and pyroptosis in the kidney
Nature Reviews Nephrology, Published online: 03 January 2023; doi:10.1038/s41581-022-00662-0Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Here, the authors provide an overview of the basic biology of gasdermins and pyroptosis with a focus on the mechanisms by which these proteins may contribute to kidney disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 3, 2023 Category: Urology & Nephrology Authors: Esteban E. Elias Brayden Lyons Daniel A. Muruve Source Type: research
Role of necroptosis in kidney health and disease
Nature Reviews Nephrology, Published online: 03 January 2023; doi:10.1038/s41581-022-00658-wNecroptosis is a form of necrotic cell death that leads to cell lysis and an inflammatory response in neighbouring tissues. This Review describes the molecular mechanisms that regulate the induction of necroptosis and current evidence implicating a role for necroptosis in the pathogenesis of kidney diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 3, 2023 Category: Urology & Nephrology Authors: Benedikt Kolbrink Friedrich A. von Samson-Himmelstjerna James M. Murphy Stefan Krautwald Source Type: research
Paths to organ damage and risk factors in AKI
Nature Reviews Nephrology, Published online: 19 December 2022; doi:10.1038/s41581-022-00669-7Acute kidney injury (AKI) is a multifactorial syndrome with a complex pathophysiology including different inflammatory cells and mediators. Current research focuses on identifying key contributing pathways, determining high-risk groups, characterizing AKI sub-phenotypes and investigating strategies for therapeutic interventions. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 19, 2022 Category: Urology & Nephrology Authors: Marlies Ostermann Mitchell H. Rosner Source Type: research
Insights into glomerular function and disease pathogenesis
Nature Reviews Nephrology, Published online: 19 December 2022; doi:10.1038/s41581-022-00667-9Insights into glomerular function and disease pathogenesis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 19, 2022 Category: Urology & Nephrology Authors: Emelie Lass én Ilse S. Daehn Source Type: research
Glucocorticoids block T cell recruitment
Nature Reviews Nephrology, Published online: 19 December 2022; doi:10.1038/s41581-022-00674-wGlucocorticoids block T cell recruitment (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 19, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Insights into the impact of pregnancy on kidney disease
Nature Reviews Nephrology, Published online: 16 December 2022; doi:10.1038/s41581-022-00663-zStudies in 2022 have advanced knowledge of pregnancy outcomes in kidney donors and transplant recipients as well as the long-term risks associated with hypertensive disorders of pregnancy. These findings should be used to support shared decision-making and appropriate care of women with or at risk of kidney disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 16, 2022 Category: Urology & Nephrology Authors: Erandi Hewawasam Shilpanjali Jesudason Source Type: research
Iron deficiency of kidney macrophages in CKD
Nature Reviews Nephrology, Published online: 16 December 2022; doi:10.1038/s41581-022-00672-yIron deficiency of kidney macrophages in CKD (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 16, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
The evolving landscape of immune-mediated glomerular diseases
Nature Reviews Nephrology, Published online: 14 December 2022; doi:10.1038/s41581-022-00666-wOver the past year, trial data have emerged on therapeutic interventions in IgA nephropathy and lupus nephritis, including the effects of different doses of glucocorticoids and several novel targeted therapies. These data, in combination with the discovery of autoantibodies targeting nephrin in minimal change disease, can inform the management of immune-mediated glomerular diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 14, 2022 Category: Urology & Nephrology Authors: Abdullah Jalal Tingting Li Source Type: research
Efficacy of empagliflozin for syndrome of inappropriate antidiuresis
Nature Reviews Nephrology, Published online: 13 December 2022; doi:10.1038/s41581-022-00673-xEfficacy of empagliflozin for syndrome of inappropriate antidiuresis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 13, 2022 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Progress towards solving the donor organ shortage
Nature Reviews Nephrology, Published online: 06 December 2022; doi:10.1038/s41581-022-00664-yKidney transplantation is the best therapy for kidney failure, but is limited by donor organ availability and the risks associated with immunosuppression. Studies in 2022 provided encouraging data about the outcomes of COVID-19 among transplant recipients, the effects of changes to organ allocation policy in the US and progress in xenotransplantation, raising hope that the organ shortage can be solved. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 6, 2022 Category: Urology & Nephrology Authors: Douglas J. Anderson Jayme E. Locke Source Type: research
New insights into cognitive decline in chronic kidney disease
Nature Reviews Nephrology, Published online: 02 December 2022; doi:10.1038/s41581-022-00656-yChronic kidney disease (CKD) is known to be associated with cognitive impairment, but the mechanisms that underlie this kidney–brain connection are unclear. A recent study provides evidence that CKD is an independent risk factor for cognitive decline due to cerebral small vessel disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 2, 2022 Category: Urology & Nephrology Authors: Wei Ling Lau Mark Fisher Source Type: research
Kidney benefits of SLGT2 inhibitors: evidence from clinical trials
Nature Reviews Nephrology, Published online: 30 November 2022; doi:10.1038/s41581-022-00659-9Kidney benefits of SLGT2 inhibitors: evidence from clinical trials (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 30, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Managing RAAS inhibitor use in advanced CKD
Nature Reviews Nephrology, Published online: 30 November 2022; doi:10.1038/s41581-022-00660-2Managing RAAS inhibitor use in advanced CKD (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 30, 2022 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Epithelial injury responses in kidney fibrosis
Nature Reviews Nephrology, Published online: 29 November 2022; doi:10.1038/s41581-022-00657-xEpithelial injury responses in kidney fibrosis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - November 29, 2022 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
