Equitable access to kidney transplants for Aboriginal and Torres Strait Islander people in Australia
Nature Reviews Nephrology, Published online: 19 October 2023; doi:10.1038/s41581-023-00780-3First Nations peoples in Australia face systemic inequities in access to kidney transplantation. The National Indigenous Kidney Transplant Taskforce was established to address these. It has provided support to clinicians to implement and evaluate innovative practices and developed strategies to address biases in the structures and models of care that create barriers to wait-listing. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 19, 2023 Category: Urology & Nephrology Authors: Stephen P. McDonald Katie Cundale Kelli J. Owen Matilda D ’Antoine Jaquelyne T. Hughes Source Type: research
TRPM channels in health and disease
Nature Reviews Nephrology, Published online: 18 October 2023; doi:10.1038/s41581-023-00777-yThe family of melastatin-like transient receptor potential (TRPM) channels comprises eight multifunctional cation channels. Here, the authors examine the functional role of each TRPM channel, including insights from channelopathies, and discuss the implications for kidney homeostasis and pathology. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 18, 2023 Category: Urology & Nephrology Authors: Vladimir Chubanov Michael K öttgen Rhian M. Touyz Thomas Gudermann Source Type: research
Embryo complementation to generate a humanized mesonephros in pigs
Nature Reviews Nephrology, Published online: 13 October 2023; doi:10.1038/s41581-023-00779-wEmbryo complementation to generate a humanized mesonephros in pigs (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 13, 2023 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
MSC therapy for diabetic kidney disease and nephrotic syndrome
Nature Reviews Nephrology, Published online: 02 October 2023; doi:10.1038/s41581-023-00776-zNew clinical studies suggest that mesenchymal stem cell (MSC) therapy can have positive clinical effects, potentially via immunomodulation, in patients with diabetic nephropathy or nephrotic syndrome. These trials suggest that the therapy is safe, but adverse reactions highlight the need to examine the source and functional attributes of MSCs closely. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - October 2, 2023 Category: Urology & Nephrology Authors: Bo Lu Lilach O. Lerman Source Type: research
Acute kidney injury in patients with burns
Nature Reviews Nephrology, Published online: 27 September 2023; doi:10.1038/s41581-023-00769-yHere, the authors discuss the pathophysiology of acute kidney injury (AKI) in patients with burns, approaches to prevention and management of AKI in this population and the application of AKI biomarkers and artificial intelligence approaches to guide treatment and predict short-term and long-term outcomes. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 27, 2023 Category: Urology & Nephrology Authors: Matthieu Legrand Audra T. Clark Javier A. Neyra Marlies Ostermann Source Type: research
The immune response to pig-to-human kidney xenografts
Nature Reviews Nephrology, Published online: 27 September 2023; doi:10.1038/s41581-023-00774-1The immune response to pig-to-human kidney xenografts (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 27, 2023 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research
Biomolecular condensates in kidney physiology and disease
Nature Reviews Nephrology, Published online: 26 September 2023; doi:10.1038/s41581-023-00767-0Biomolecular condensates are membraneless compartments that typically contain proteins and RNAs and broadly affect many cell types and organs. In the kidney in particular, rapid and reversible assembly of biomolecular condensates occurs through the process of hyperosmotic phase separation. This Review describes emerging evidence for, and the impact of, biomolecular condensates on kidney physiology and disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 26, 2023 Category: Urology & Nephrology Authors: Guoming Gao Emily S. Sumrall Sethuramasundaram Pitchiaya Markus Bitzer Simon Alberti Nils G. Walter Source Type: research
Gene therapy in a model of nephrotic syndrome
Nature Reviews Nephrology, Published online: 25 September 2023; doi:10.1038/s41581-023-00772-3Gene therapy in a model of nephrotic syndrome (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 25, 2023 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research
The role of complement in kidney disease
Nature Reviews Nephrology, Published online: 21 September 2023; doi:10.1038/s41581-023-00766-1The complement system is often involved in immune-driven kidney injury. In this Review, the authors discuss complement activation in a variety of kidney diseases, including conditions not traditionally considered to be immune-mediated, and the potential of complement therapeutics for the treatment of kidney disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 21, 2023 Category: Urology & Nephrology Authors: Vojtech Petr Joshua M. Thurman Source Type: research
Use of kidneys from SARS-CoV-2 infected donors
Nature Reviews Nephrology, Published online: 21 September 2023; doi:10.1038/s41581-023-00771-4Use of kidneys from SARS-CoV-2 infected donors (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 21, 2023 Category: Urology & Nephrology Authors: Monica Wang Source Type: research
Lymph vessels, Na+ and the teleological science of hypertension
Nature Reviews Nephrology, Published online: 15 September 2023; doi:10.1038/s41581-023-00770-5A recent study reports that adenosine A2A receptor-mediated lymphangiogenesis increases lymphatic clearance of excess Na+ from the skin and reduces blood pressure, whereas impairment of this process leads to salt-sensitive hypertension. These findings raise intriguing physiological questions regarding the relationships among sodium, water and blood pressure. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 15, 2023 Category: Urology & Nephrology Authors: Jens M. Titze Source Type: research
Sex differences in renal transporters: assessment and functional consequences
Nature Reviews Nephrology, Published online: 08 September 2023; doi:10.1038/s41581-023-00757-2This Review summarizes our current understanding of sex differences in renal fluid and electrolyte transporters, based primarily on studies in rodents. The authors describe the physiological consequences of these differences, based on information from experimental studies and from model predictions, and discuss the differential impact of sex on transporter regulation by hormones, diet and acid–base status. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 8, 2023 Category: Urology & Nephrology Authors: Alicia A. McDonough Autumn N. Harris Lingyun (Ivy) Xiong Anita T. Layton Source Type: research
Interorgan communication networks in the kidney–lung axis
Nature Reviews Nephrology, Published online: 04 September 2023; doi:10.1038/s41581-023-00760-7Here, the authors review the current understanding of interorgan crosstalk mechanisms, with a focus on interorgan communication in the kidney–lung axis during acute or chronic disease of the kidney or lung. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 4, 2023 Category: Urology & Nephrology Authors: Yohei Komaru Yun Zhu Bai Daniel Kreisel Andreas Herrlich Source Type: research
Author Correction: Regulatory T cells in autoimmune kidney diseases and transplantation
Nature Reviews Nephrology, Published online: 04 September 2023; doi:10.1038/s41581-023-00768-zAuthor Correction: Regulatory T cells in autoimmune kidney diseases and transplantation (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - September 4, 2023 Category: Urology & Nephrology Authors: Norihisa Mikami Shimon Sakaguchi Source Type: research
Designing acute kidney injury clinical trials
Nature Reviews Nephrology, Published online: 31 August 2023; doi:10.1038/s41581-023-00758-1Several factors complicate the identification of effective interventions that can improve the outcomes of patients with acute kidney injury (AKI). Here, the authors discuss key design considerations for clinical trials in hospitalized patients with AKI, including the selection of adequate patient cohorts and study end points. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - August 31, 2023 Category: Urology & Nephrology Authors: Alexander Zarbock Lui G. Forni Marlies Ostermann Claudio Ronco Sean M. Bagshaw Ravindra L. Mehta Rinaldo Bellomo John A. Kellum Source Type: research
