A pathway of osmotic stress-induced necroptosis

Nature Reviews Nephrology, Published online: 01 August 2022; doi:10.1038/s41581-022-00607-7Necroptosis is a form of regulated necrosis in which RIPK3 is activated by binding to RIP homotypic interaction motif (RHIM)-containing proteins. Now, researchers describe a non-canonical pathway of RIPK3 activation that is triggered by osmotic stress and NHE1-mediated cytosol alkalinization. This previously undescribed mechanism of osmotic stress-induced necroptosis might have implications for treating cancer and other diseases.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research