Activation and regulation of alloreactive T cell immunity in solid organ transplantation

Nature Reviews Nephrology, Published online: 27 July 2022; doi:10.1038/s41581-022-00600-0Alloimmune T cell responses have a crucial role in graft rejection. Here, the authors examine the factors that regulate T cell activation, differentiation and function in secondary lymphoid organs and in the graft, including the different pathways of allorecognition, innate–adaptive immunity crosstalk and the role of survival cytokines.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research