Interrogating heterogeneity of cysteine-engineered antibody-drug conjugates and antibody-oligonucleotide conjugates by capillary zone electrophoresis-mass spectrometry
Volume 15, Issue 1, January-December 2023 . (Source: mAbs)
Source: mAbs - June 29, 2023 Category: Biomedical Science Authors: Tian XuFan ZhangDaoyang ChenLiangliang SunDaniela TomazelaLaurence Fayadat-Dilmana Department of Chemistry Michigan State University, East Lansing MI 48824 USAb Discovery Biologics, Protein Sciences, Merck & Co., Inc, South San Francisco, CA 94080 USA Source Type: research

Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier
Volume 15, Issue 1, January-December 2023 . (Source: mAbs)
Source: mAbs - June 29, 2023 Category: Biomedical Science Authors: Jason TienDmitri LeonoudakisRalitsa PetrovaVivian TrinhTetsuya TauraDebapriya SenguptaLisa JoAngela ShoYong YunEric DoanAnita JaminHussein HallakDavid S. WilsonJennifer R. Strattona Biologics Discovery Science, Teva Pharmaceutical Industries Ltd, Redwood Source Type: research

Interrogating heterogeneity of cysteine-engineered antibody-drug conjugates and antibody-oligonucleotide conjugates by capillary zone electrophoresis-mass spectrometry
Volume 15, Issue 1, January-December 2023 . (Source: mAbs)
Source: mAbs - June 29, 2023 Category: Biomedical Science Authors: Tian Xu Fan Zhang Daoyang Chen Liangliang Sun Daniela Tomazela Laurence Fayadat-Dilman Source Type: research

Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier
Volume 15, Issue 1, January-December 2023 . (Source: mAbs)
Source: mAbs - June 29, 2023 Category: Biomedical Science Authors: Jason Tien Dmitri Leonoudakis Ralitsa Petrova Vivian Trinh Tetsuya Taura Debapriya Sengupta Lisa Jo Angela Sho Yong Yun Eric Doan Anita Jamin Hussein Hallak David S. Wilson Jennifer R. Stratton Source Type: research

Understanding the structure –property relationship of bispecific monoclonal antibodies with Fc site-specific substitutions
Volume 15, Issue 1, January-December 2023 . (Source: mAbs)
Source: mAbs - June 26, 2023 Category: Biomedical Science Authors: Bo ZhaoYunlong ZhaoStephanie AdaniyaYue FuYoumi MoonJustin HeftelShuzhen ChenHui XiaoNing Lia Analytical Chemistry, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USAb Protein Biochemistry, Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA Source Type: research

Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain
Volume 15, Issue 1, January-December 2023 . (Source: mAbs)
Source: mAbs - June 22, 2023 Category: Biomedical Science Authors: Young D. KwonAmarendra PeguEun Sung YangBaoshan ZhangMichael F. BenderMangaiarkarasi AsokanQingbo LiuKrisha McKeeBob C. LinTracy LiuMark K. LouderReda RawiMateo ReveizAndrew J. SchaubChen-Hsiang ShenNicole A. Doria-RosePaolo LussoJohn R. MascolaPeter D. K Source Type: research

Efficient production of bispecific antibody by FAST-IgTM and its application to NXT007 for the treatment of hemophilia A
Volume 15, Issue 1, January-December 2023 . (Source: mAbs)
Source: mAbs - June 20, 2023 Category: Biomedical Science Authors: Hikaru KogaTakashi YamanoJuan BetancurSatoko NagatomoYousuke IkedaKazuki YamaguchiYoshiaki NabuchiKazuki SatoYuri Teranishi-IkawaMotohiko SatoHiroyuki HirayamaAkira HayasakaTakuya TorizawaKenta HarayaZenjiro SampeiHirotake ShiraiwaTakehisa KitazawaTomoyuk Source Type: research

A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation
Volume 15, Issue 1, January-December 2023 . (Source: mAbs)
Source: mAbs - June 19, 2023 Category: Biomedical Science Authors: Alessandro MegaAman MebrahtuGustav AnianderEva RyerAnnette Sk öldAnna SandegrenEva Backström RydinJohan RockbergArne ÖstmanFredrik Y. Frejda Department of Science and Product Development, Affibody Medical AB, Solna, Swedenb School of Engineering Scienc Source Type: research

A HER2-targeted antibody-novel DNA topoisomerase I inhibitor conjugate induces durable adaptive antitumor immunity by activating dendritic cells
Volume 15, Issue 1, January-December 2023 . (Source: mAbs)
Source: mAbs - June 14, 2023 Category: Biomedical Science Authors: Xiaoding TanPeng FangKaiying LiMeng YouYuxia CaoHui XuXiaohong ZhuLu WangXin WeiHaiying WenWendi LiLei ShiXiaowei SunDongan YuHuikai ZhuZhenzhen WangDatao LiuHui ShenWei ZhouMaomao Ana Department of Pharmacology, Shanghai Tenth People ’s Hospital, Tongj Source Type: research

Design of antibody variable fragments with reduced reactivity to preexisting anti-drug antibodies
Volume 15, Issue 1, January-December 2023 . (Source: mAbs)
Source: mAbs - June 14, 2023 Category: Biomedical Science Authors: Maria U. JohanssonChristopher WeinertDietrich Alexander ReichardtDana MahlerDania DiemChristian HessDiana FeusiSimon CarnalJulia TietzNoreen GiezendannerFabio Mario SpigaDavid UrechStefan WarmuthNumab Therapeutics AG, Horgen, Switzerland Source Type: research

A HER2-targeted antibody-novel DNA topoisomerase I inhibitor conjugate induces durable adaptive antitumor immunity by activating dendritic cells
Volume 15, Issue 1, January-December 2023 . (Source: mAbs)
Source: mAbs - June 14, 2023 Category: Biomedical Science Authors: Xiaoding Tan Peng Fang Kaiying Li Meng You Yuxia Cao Hui Xu Xiaohong Zhu Lu Wang Xin Wei Haiying Wen Wendi Li Lei Shi Xiaowei Sun Dongan Yu Huikai Zhu Zhenzhen Wang Datao Liu Hui Shen Wei Zhou Maomao An Source Type: research