Effects of treadmill training on myelin proteomic markers and cerebellum morphology in a rat model of cuprizone-induced toxic demyelination
Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS). If demyelination is persistent, it will result in irreversible axonal injury and loss. The purpose of the current study was to investigate the effects of treadmill training on myelin proteomic markers and cerebellum morphology in a rat model of cuprizone-induced toxic demyelination. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 7, 2024 Category: Allergy & Immunology Authors: Alireza Lotfi, Maryam Abbasi, Nasrin Karami, Hadis Arghavanfar, Fatemeh Kazeminasab, Sara K. Rosenkranz Source Type: research
Inherited chromosomally-integrated human herpes virus 6 confounding test results in a patient with myelitis and optic neuritis – A case report
This article reports a case of a similarly observed clinical triad, but with a different conclusion and explanation supp orted by laboratory test results and evidence from our literature review. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 4, 2024 Category: Allergy & Immunology Authors: Zhibin Tan, Yvonne May Fen Chia, Xiaomin Mu, You-Jiang Tan Tags: Short Communication Source Type: research
Polygalasaponin F ameliorates middle cerebral artery occlusion-induced focal ischemia / reperfusion injury in rats through inhibiting TXNIP/NLRP3 signaling pathway
Polygalasaponin F (PGSF), an oleanane triterpenoid saponin extracted from Polygala japonica, has been demonstrated with neuroprotective effect. However, the therapeutic effects and mechanisms of PGSF on focal ischemia remain unknown; (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 3, 2024 Category: Allergy & Immunology Authors: Yao Chen, Hanzhou Li, Yan Yang, Lei Feng, Ling Yang, Jie Zhao, Xiaochi Xin, Shuquan Lv, Xixing Fang, Weibo Wen, Youxiang Cui, Huantian Cui Source Type: research
Dysregulated autotaxin expression by T cells in multiple sclerosis
Multiple sclerosis (MS) is a demyelinating disease characterized by infiltration of autoreactive T cells into the central nervous system (CNS). In order to understand how activated, autoreactive T cells are able to cross the blood brain barrier, the unique molecular characteristics of pathogenic T cells need to be more thoroughly examined. In previous work, our laboratory found autotaxin (ATX) to be upregulated by activated autoreactive T cells in the mouse model of MS. ATX is a secreted glycoprotein that promotes T cell chemokinesis and transmigration through catalysis of lysophoshphatidic acid (LPA). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 3, 2024 Category: Allergy & Immunology Authors: Cora L. Petersen-Cherubini, Yue Liu, Joshua L. Deffenbaugh, Shawn P. Murphy, Matthew Xin, Christina N. Rau, Yuhong Yang, Amy E. Lovett-Racke Source Type: research
Early-stage volume losses in the corpus callosum and thalamus predict the progression of brain atrophy in patients with multiple sclerosis
A method that can be used in the early stage of multiple sclerosis (MS) to predict the progression of brain volume loss (BVL) has not been fully established. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 1, 2024 Category: Allergy & Immunology Authors: Juichi Fujimori, Ichiro Nakashima Source Type: research
"Lipopolysaccharide-induced animal models for neuroinflammation – An overview."
Neuroinflammation is a pathological mechanism contributing to neurodegenerative diseases. For in-depth studies of neuroinflammation, several animal models reported reproducing behavioral dysfunctions and cellular pathological mechanisms induced by brain inflammation. One of the most popular models of neuroinflammation is the one generated by lipopolysaccharide exposure. Despite its importance, the reported results using this model show high heterogeneity, making it difficult to analyze and compare the outcomes between studies. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 31, 2023 Category: Allergy & Immunology Authors: Ana Alexandra Flores da Silva, Mariana Bernardo Fiadeiro, Liliana In ácio Bernardino, Carla Sofia Pais Fonseca, Graça Maria Fernandes Baltazar, Ana Clara Braz Cristóvão Source Type: research
Biomarkers of disability worsening in inactive primary progressive multiple sclerosis
To investigate serum biomarkers of progression in inactive primary progressive multiple sclerosis (PPMS). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 23, 2023 Category: Allergy & Immunology Authors: Maria-Elizabeth Baeva, Isabelle Tottenham, Marcus Koch, Carlos Camara-Lemarroy Source Type: research
Increased production of inflammatory cytokines by circulating monocytes in mesial temporal lobe epilepsy: A possible role in drug resistance
We analyzed peripheral blood mononuclear cells (PBMCs) and serum inflammatory biomarkers in patients with mesial temporal lobe epilepsy (drug-resistant – DR, vs. drug-sensitive – DS). Patients with epilepsy showed higher levels of serum CCL2, CCL3, IL-8 and AOPP, and lower levels of FRAP and thiols compared to healthy controls (HC). Although none of the serum biomarkers distinguished DR from DS patients, when analysing intracellular cytokines a fter in vitro stimulation, DR patients presented higher percentages of IL-1β and IL-6 positive monocytes compared to DS patients and HC. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 23, 2023 Category: Allergy & Immunology Authors: C. Milano, M. Montali, S. Barachini, I.S. Burzi, F. Pratesi, L. Petrozzi, L. Chico, R. Morganti, G. Gambino, L. Rossi, R. Ceravolo, G. Siciliano, P. Migliorini, I. Petrini, C. Pizzanelli Source Type: research
Electroconvulsive therapy for catatonia in anti-NMDA receptor encephalitis: A case series
Anti-NMDAR encephalitis is the most common cause of immune-mediated catatonia. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 22, 2023 Category: Allergy & Immunology Authors: Lara Wadi, Vishal Mandge Tags: Short Communication Source Type: research
Neuropsychological profiles comparison between Multiple Sclerosis patients and Multiple Sclerosis patients with overlapping features of systemic lupus erythematosus
This study aimed to compare the neuropsychological profiles of patients with MS, and MS and coexisting SLE features. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 21, 2023 Category: Allergy & Immunology Authors: Konstantina Stavrogianni, Dimitrios K. Kitsos, Vasileios Giannopapas, Athanasios K. Chasiotis, Niki Christouli, Panagiotis G. Paraskevas, Christina Zompola, Georgios Tsivgoulis, George P. Paraskevas, Sotirios Giannopoulos Source Type: research
Rs1800629 polymorphism in TNF-alpha is associated with the susceptibility and initial short-term glucocorticoids efficacy in myasthenia gravis patients
In this study, we enrolled 409 adult MG patients and 487 healthy individuals to investigate the association between TNF-α polymorphism and MG. We found the rs1800629 A a llele frequency was significantly higher in the MG group than in the control group. Subgroup analysis revealed that the A allele frequencies were significantly higher in the early-onset subgroup, non-thymoma subgroup, ocular-onset subgroup, and mild severity subgroup than in the control group. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 20, 2023 Category: Allergy & Immunology Authors: Hong-Yan Li, Meng Xia, Min Song, Yanchen Xie, Qi Wang, Yao-Xian Yue, Hai-Feng Li Source Type: research
YTHDF2 alleviates microglia activation via promoting circHIPK2 degradation
Microglial activation is a common cellular dysfunction in central nervous system inflammation, accompanied by abnormal expression of circular RNAs (circRNAs). YTHDF2, a N6-methyladenosine (m6A) reader, is known as a key element in RNA degradation. Here, lipolysaccharide induced microglia activation in mouse cortex and BV2 cells, accompanied by the decreased YTHDF2 and elevated circHIPK2. YTHDF2 overexpression or circHIPK2 knockdown in BV2 microglia inhibited the expressions of iNOS protein, IL-1 β mRNA and IL-6 mRNA. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 18, 2023 Category: Allergy & Immunology Authors: Rongrong Huang, Ming Sun, Weiwei Wang, Xiaoyu Yu, Fan Liu Source Type: research
Exosome-transmitted ANGPTL1 suppresses angiogenesis in glioblastoma by inhibiting the VEGFA/VEGFR2/Akt/eNOS pathway
Glioblastoma (GBM) is a highly vascularized malignancy that relies on new vessel generation, and thus targeting angiogenesis has been a promising anti-GBM approach. ANGPTL1 is well-known for its anti-angiogenic property; nevertheless, its role in GBM is yet to be explored. Recently, the crucial role of exosomes (Exos) as intercellular communication mediators has gained prominence in GBM therapy. This work aimed to explore the role of exosomal ANGPTL1 in GBM angiogenesis and its mechanisms. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 15, 2023 Category: Allergy & Immunology Authors: Dong Wang, Huichen Li, Tianxiang Zeng, Qiang Chen, Weilong Huang, Yujing Huang, Yuqing Liao, Qiuhua Jiang Source Type: research
Systemic administration of anti-CD20 indirectly reduces B cells in the inflamed meninges in a chronic model of central nervous system autoimmunity
Anti-CD20 B cell depleting therapies have demonstrated that B cells are important drivers of disease progress in Multiple Sclerosis, although the pathogenic mechanisms are not well understood. A population of B cells accumulates in the inflamed meninges in MS and also some chronic animal models of disease, typically adjacent to demyelinating lesions. The role of these meningeal B cells in disease is not known, nor is their susceptibility to anti-CD20 therapy. Here, we administered anti-CD20 to 2D2 IgHMOG spontaneous experimental autoimmune encephalomyelitis mice in the chronic phase of disease, after the establishment of m...
Source: Journal of Neuroimmunology - December 15, 2023 Category: Allergy & Immunology Authors: Yodit Tesfagiorgis, Eden Kemal, Heather C. Craig, Kate A. Parham, Steven M. Kerfoot Source Type: research
Clinical features and prognosis of Tibetan patients with neuromyelitis optica spectrum disorder are different from those of Han Chinese patients
We compared the prognosis of Tibetan and Han Chinese patients with neuromyelitis optica spectrum disorder (NMOSD). The Expanded Disability Status Scale (EDSS) score at each attack, response to immunosuppressive therapy, risk of first relapse, severe attack, visual disability, motor disability, and total risk of disability were compared between Tibetan and Han Chinese patients. Tibetan patients showed higher EDSS during acute attacks. Annualized relapse rate did not differ between groups. Risk of severe attack, visual disability, and total risk of disability were higher in Tibetan patients. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 13, 2023 Category: Allergy & Immunology Authors: Wenqin Luo, Xiaofei Wang, Lingyao Kong, Hongxi Chen, Ziyan Shi, Hongyu Zhou Source Type: research
