Overlapping Epstein-Barr virus encephalitis and autoimmune glial fibrillary acidic protein astrocytopathy
We describe three cases of overlapping Epstein-Barr virus (EBV) Encephalitis and Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy (GFAP-A). The three cases all presented with initial symptoms of fever, headache, coma, and posture tremor of the upper limbs, then followed by limb weakness and dysuria. All of the three cases were on ventilators. Case 1 and 2 improved dramatically after intravenous methylprednisoloneand immunoglobulin treatment. However, case 3 presented dyspneic, and died from gastrointestinal hemorrhage. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 7, 2023 Category: Allergy & Immunology Authors: Jin-ru Zhang, Sheng Zhuang, Xiao-dong Xu, Wen-li Song, Ke-ru Li, Yu Jiang, Xiao-yu Cheng, Ji-jun Shi, Wei-dong Hu, Chun-feng Liu, Yan-lin Zhang Tags: Short Communication Source Type: research
Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 7, 2023 Category: Allergy & Immunology Authors: Synne Brune-Ingebretsen, Einar A. H øgestøl, Nicole Kerlero de Rosbo, Pål Berg-Hansen, Cathrine Brunborg, Kaj Blennow, Henrik Zetterberg, Friedemann Paul, Antonio Uccelli, Pablo Villoslada, Hanne F. Harbo, Tone Berge Source Type: research
Clinical characteristics of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy in children: A case series of 16 patients
To investigate the clinical characteristics of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy in children. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 7, 2023 Category: Allergy & Immunology Authors: Tianyi Li, Xiujuan Li, Siqi Hong, Li Jiang, Jiannan Ma Source Type: research
Effects of a high saturated fatty acid diet on the intestinal microbiota modification and associated impacts on Parkinson's disease development
Recent research has focused on the link between diet, intestinal microbiota, and the impact of excessive consumption of saturated fatty acids. Saturated fatty acids, found in animal fats, dairy, and processed foods, contribute to dysbiosis, increase intestinal barrier permeability, chronic low-grade inflammation, oxidative stress, and dysfunction of the blood-brain barrier, affecting the central nervous system. High intake of saturated fatty acids is associated with an increased risk of developing Parkinson's disease (PD). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 4, 2023 Category: Allergy & Immunology Authors: Sophia Alexandre de Queiroz Cavalcanti, Leonardo Augusto de Almeida, Juciano Gasparotto Tags: Review Article Source Type: research
Disordered gut microbiota and changes in short-chain fatty acids and inflammatory processes in stress-vulnerable mice
In this study, Classic behavioral tests were used to categorize C57BL/6 J mice into a CUMS-vulnerable and a CUMS-resilient group after they were exposed to chronic unpredictable mild stress (CUMS). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 4, 2023 Category: Allergy & Immunology Authors: Wenjuan Han, Yaxin Zheng, Lan Wang, Cuixia An Source Type: research
Serum B-cell activating factor is not a potential biomarker for disease activity in chronic inflammatory demyelinating polyneuropathy
B-cell activating factor (BAFF) is a crucial cytokine for differentiation and survival of B-cells and correlates to disease activity in some auto-immune diseases. To evaluate BAFF as a biomarker for disease activity in chronic inflammatory demyelinating polyneuropathy (CIDP), serum BAFF levels were measured at varying disease stages: patients starting treatment, patients starting treatment withdrawal, patients in remission and healthy controls. Serum BAFF levels were elevated in patients compared to healthy controls, but did not differ between patients starting treatment and patients in remission. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 3, 2023 Category: Allergy & Immunology Authors: Milou R. Michael, Luuk Wieske, Marleen J. Koel-Simmelink, Ivo N. van Schaik, Charlotte E. Teunissen, Filip Eftimov Tags: Short Communication Source Type: research
Prolonged STAT1 activation in neurons drives a pathological transcriptional response
Neurons require physiological IFN- γ signaling to maintain central nervous system (CNS) homeostasis, however, pathological IFN-γ signaling can cause CNS pathologies. The downstream signaling mechanisms that cause these drastically different outcomes in neurons has not been well studied. We hypothesized that different levels of IFN- γ signaling in neurons results in differential activation of its downstream transcription factor, signal transducer and activator of transduction 1 (STAT1), causing varying outcomes. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 1, 2023 Category: Allergy & Immunology Authors: Danielle N. Clark, Shane M. O'Neil, Li Xu, Justin T. Steppe, Justin T. Savage, Kavya Raghunathan, Anthony J. Filiano Source Type: research
Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - July 30, 2023 Category: Allergy & Immunology Source Type: research
Systemic administration of Shikonin ameliorates cognitive impairment and neuron damage in NPSLE mice
Shikonin is an anti-inflammatory natural herbal drug extracted from Lithospermum erythrorhizon and its therapeutic effect on neuropsychiatric systemic lupus erythematosus (NPSLE) is yet unknown. In our study, Shikonin significantly reversed the cognitive impairment and alleviated the brain tissue damage in NPSLE mice. The permeability of blood-brain barrier was also verified to be repaired in Shikonin-treated NPSLE mice. In particular, we found that Shikonin alleviated neuroinflammation through inhibiting β-catenin signaling pathway, thereby depressing the activation of microglia and the loss of neuronal synapses. (Source...
Source: Journal of Neuroimmunology - July 28, 2023 Category: Allergy & Immunology Authors: Jiali Ni, Xuan Liu, Ruowen Zhang, Hailin Wang, Jun Liang, Yayi Hou, Huan Dou Source Type: research
Rituximab induces a transient fluctuation of peripheral and follicular helper T cells in neuromyelitis optica spectrum disorder
Autoreactive CD4+ helper T cells are implicated in the pathogenesis of neuromyelitis optica spectrum disorder (NMOSD). Both PD-1+CXCR5+CD4+ T follicular helper (Tfh) cells and PD-1+CXCR5 −CD4+ T peripheral helper (Tph) cells can contribute to B-cell immune responses and the production of antibodies. Here we show the effect of B-cell depletion with rituximab on the homeostasis of Tfh cells, Tph cells and their subsets in patients with NMOSD. After rituximab treatment, total Tph cel ls, total Tfh cells, Tph17 cells, Tph17.1 cells, Tph1 cells, and Tfh1 cells tended to decrease at month 1, but gradually increased at month 6 ...
Source: Journal of Neuroimmunology - July 28, 2023 Category: Allergy & Immunology Authors: Zhenning Huang, Ye Liu, Xueting An, Chen Zhang, Tian-Xiang Zhang, Huining Li, Bin Feng, Yan-Yan Li, Chao Zhang Source Type: research
Effects of BL 23 (Shenshu) acupuncture on serum cytokine levels in healthy adults: A randomized double-blind sham-controlled phase 1 study
The purpose of this study was to evaluate the safety and efficacy of BL 23 (Shenshu) acupuncture on serum cytokine levels. Sixteen healthy adults were randomized into the BL 23 acupuncture group or pseudo-acupuncture group and changes of serum cytokines were analyzed. The changes in IL-13, TNF- α, and GM-CSF levels were different between the BL 23 acupuncture group and pseudo-acupuncture group (P (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - July 28, 2023 Category: Allergy & Immunology Authors: Eiko Murakami, Akiyuki Uzawa, Yoshihito Ozawa, Manato Yasuda, Yosuke Onishi, Yukiko Ozawa, Hiroyuki Akamine, Mariko Kawamoto, Yuki Shiko, Yohei Kawasaki, Satoshi Kuwabara Source Type: research
Cladribine tablets in people with relapsing multiple sclerosis: A real-world multicentric study from southeast European MS centers
Cladribine is an oral disease-modifying drug authorized by the European Medicine Agency for the treatment of highly active relapsing multiple sclerosis (MS). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - July 27, 2023 Category: Allergy & Immunology Authors: Ivan Adamec, Gregor Brecl Jakob, Cecilia Rajda, Jelena Drulovi ć, Ljiljana Radulović, Vanja Bašić Kes, Ines Lazibat, Julija Rimac, Igor Cindrić, Tihana Gržinčić, Ana Abičić, Barbara Barun, Tereza Gabelić, Sarah Gomezelj, Šarlota Mesaroš, Tatj Source Type: research
Amphiphysin-IgG autoimmune sciatic neuropathy and facial neuropathy related to primary central nervous system lymphoma: A case report
We reported a 61-year-old man presented with 10-month progressing left sciatic neuropathy and 10-day right facial neuropathy. Serum amphiphysin-IgG was positive. 18F-FDG PET/CT of the whole body showed no signs of malignancy. Treatment with plasma exchange and oral prednisone relieved the symptoms. Nine months later, right hemiparesis and seizure of right limbs developed. 18F-FDG and 18F-PBR06 (18 kDa translocator protein, TSPO) radioligand PET/MRI of the whole body revealed intense uptake in the intracranial lesions. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - July 25, 2023 Category: Allergy & Immunology Authors: Xiaoying Yao, Chenpeng Zhang, Ying Zhang, Jieli Geng, Shuwei Bai, Yong Hao, Yangtai Guan Tags: Short Communication Source Type: research
Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review
In this narrative review, we examine the association between gut dysbiosis, neuroinflammation, and stress-linked disorders, including depression, anxiety, and post-traumatic stress disorder (PTSD), and investigate whether tryptophan (TRP) metabolism and platelets play a role in this association.The mechanisms underlying the aetiology of stress-linked disorders are complex and not yet completely understood. However, a potential link between chronic inflammation and these disorders may potentially be found in TRP metabolism and platelets. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - July 24, 2023 Category: Allergy & Immunology Authors: Carlien Rust, Stefanie Malan-Muller, Leigh L. van den Heuvel, Daniel Tonge, Soraya Seedat, Etheresia Pretorius, Sian Hemmings Tags: Review Article Source Type: research
Natural killer cells have an activated profile in early Parkinson's disease
Immune dysregulation is heavily implicated in Parkinson's disease (PD) but the role of Natural Killer (NK) cells has not been well characterised. Accumulating evidence indicates the immune response peaks early in the disease, hence this study focused on characterising NK cells in recently diagnosed PD. PBMCs were obtained from PD cases ( (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - July 24, 2023 Category: Allergy & Immunology Authors: J. Holbrook, B. Patel, M. Camacho, L. Kahanawita, J. Greenland, C.H. Williams-Gray Tags: Short Communication Source Type: research
