Myelin oligodendrocyte glycoprotein-IgG1 associated disorders (MOGAD) following SARS-CoV-2 infection: A case series
This case series describes 9 patients diagnosed with myelin oligodendrocyte glycoprotein (MOG)-IgG1 associated disorder (MOGAD) following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Patients developed neurological symptoms between 4 days and 3 weeks following SARS-CoV-2 infection. Myelitis was observed in 4 patients; 4 presented with optic neuritis; and encephalopathy was observed in 3. Serum MOG-IgG cell-based assay was positive in each case. Most patients had near-complete recovery following acute immunosuppression. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - July 13, 2022 Category: Allergy & Immunology Authors: Jeffrey Lambe, Marisa P. McGinley, Brandon P. Moss, Yang Mao-Draayer, Roman Kassa, John R. Ciotti, Sara Mariotto, Amy Kunchok Tags: Short Communication Source Type: research
Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring
Maternally transferred autoantibodies can negatively impact the development and health of offspring, increasing the risk of neurodevelopmental disorders. We used embryo transfers to examine maternofoetal immune imprinting in the autoimmune BXSB/MpJ mouse model. Anti-double-stranded DNA antibodies and total immunoglobulins were measured, using allotypes of the IgG subclass to distinguish maternally transferred antibodies from those produced endogenously. Frequencies of germinal center and plasma cells were analysed by flow cytometry. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - July 12, 2022 Category: Allergy & Immunology Authors: Sofie Vestergaard Fonager, Gudrun Winther, Thomas Rea Wittenborn, Lisbeth Jensen, Cecilia Fahlquist-Hagert, Lisbeth Ahm Hansen, Ernst-Martin F üchtbauer, Marina Romero-Ramos, Søren Egedal Degn Source Type: research
Prevalence of iatrogenic CNS inflammation at a tertiary neuroimmunology clinic
Various vaccines, tumor-necrosis-factor-alpha inhibitors (TNFAIs), immune-checkpoint inhibitors (ICIs), and other immunomodulators have been linked to inflammatory CNS events. The prevalence of iatrogenic events in the neuroimmunology clinic is unknown. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - July 12, 2022 Category: Allergy & Immunology Authors: Hannah Kelly, Jessica Johnson, Collin Jakubecz, Alessandro Serra, Hesham Abboud Source Type: research
Longitudinal analysis of anti-drug antibody development in multiple sclerosis patients treated with interferon beta-1a (Rebif ™) using B cell receptor repertoire analysis
A significant proportion of multiple sclerosis (MS) patients treated with interferon beta-1a (Rebif ™) develop anti-drug antibodies (ADA) with a negative impact on treatment efficacy. We hypothesized that high-throughput B-cell receptor (BCR) repertoire analysis could be used to predict and monitor ADA development. To study this we analyzed 228 peripheral blood samples from 68 longitudinally fol lowed patients starting on interferon beta-1a. Our results show that whole blood BCR analysis does not reflect, and does not predict ADA development in MS patients treated with interferon beta-1a. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - July 12, 2022 Category: Allergy & Immunology Authors: Linda van der Weele, Sabrina Pollastro, Barbera D.C. van Schaik, Antoine H.C. van Kampen, Ilse T.G. Niewold, Taco W. Kuijpers, Clemens Warnke, Poul Erik H. Jensen, Daniel Kramer, Malin Ryner, Christina Hermanrud, Pierre D önnes, Marc Pallardy, Sebastian Source Type: research
The neutrophil-to-lymphocyte ratio is associated with intubation in pediatric anti-NMDA receptor encephalitis: A retrospective study
BackgroundThe neutrophil-to-lymphocyte ratio (NLR) may predict poor outcomes in adult anti-NMDAR encephalitis (NMDARE). The association of NLR with outcomes in pediatric NMDARE was examined.MethodsPediatric NMDARE patients (N = 36) were retrospectively studied.ResultsHigh NLR (>6) had a higher proportion of tumors (43% versus 7%) and higher intubation rates (100% versus 38%, p = 0.008). Multivariate analyses showed that high NLR did not correlate with one-year outcomes, inpatient length of stay (LOS), or with tumor, but was associated with intubation and rehabilitation LOS. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - July 12, 2022 Category: Allergy & Immunology Authors: Nisha Kashyap, Morgan Morris, Leah B. Loerinc, Macarthur Benoit, Laura Blackwell, Robyn Howarth, Grace Gombolay Tags: Short Communication Source Type: research
