Neurosarcoidosis causing hydrocephalus: A case series
Sarcoidosis is a granulomatous inflammatory disease that rarely affects the central nervous system as neurosarcoidosis. Neurosarcoidosis can affect any part of the nervous system causing a wide variety of clinical presentations ranging from seizures to optic neuritis. Here, we highlight rare cases of obstructive hydrocephalus in patients with neurosarcoidosis to make clinicians aware of this potential disease complication. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - June 5, 2023 Category: Allergy & Immunology Authors: Elijah Lackey, Jeffrey Shen, Kristen Veal, Suma Shah, Christopher Eckstein Tags: Short Communication Source Type: research
Corrigendum to “MP4- and MOG:35–55-induced EAE in C57BL/6 mice differentially targets brain, spinal cord and cerebellum” [J Neuroimmunol 189(1–2) (2007) 31–40]
The authors regret a mistake in Table 2. The table suggests that there was hardly any infiltration in the parenchyma of the spinal cord and cerebellum in chronic MP4-induced EAE. However, MP4-immunized mice frequently displayed infiltration in these regions at that time point. The authors would like to apologise for any inconvenience caused. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - June 2, 2023 Category: Allergy & Immunology Authors: Stefanie Kuerten, Dilyana A. Kostova-Bales, Lukas P. Frenzel, Justine T. Tigno, Magdalena Tary-Lehmann, Doychin N. Angelov, Paul V. Lehmann Source Type: research
The status of knowledge on migraines: The role of microglia
Migraines are a considerable social problem and economic burden worldwide. Current acute treatments are based on inhibiting meningeal neurogenic inflammation which has poor results in some patients, whereas the site of action of prophylactic medicines are unknown; therefore, exploring new treatment mechanisms and methods is increasingly needed. Recent evidence suggests that microglia and microglia-mediated neuroinflammation are important in migraine pathogenesis. In the cortical spreading depression (CSD) migraine model, microglia were activated after multiple CSD stimulations, suggesting that microglial activation may be ...
Source: Journal of Neuroimmunology - May 31, 2023 Category: Allergy & Immunology Authors: Wei He, Yanyun Wang, Yixin Zhang, Yinan Zhang, Jiying Zhou Source Type: research
Normocomplementemic urticarial vasculitis in a patient with multiple sclerosis on glatiramer acetate
Glatiramer acetate is one of the oldest and safest disease modifying therapies used to treat relapsing-remitting multiple sclerosis. Urticarial vasculitis is a rare complication of treatment with glatiramer acetate, having been reported by only two others previously. Here, we describe a case of normocomplementemic urticarial vasculitis diagnosed on skin punch biopsy in a patient with multiple sclerosis treated with glatiramer acetate for five years. Upon treatment with steroids and an antihistamine along with discontinuation of glatiramer acetate, the urticaria resolved. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 25, 2023 Category: Allergy & Immunology Authors: Candace Marsters, Nabeela Nathoo, Lindsay Amatto, Russell Wong, Muhammad N. Mahmood, Jennifer A. McCombe Tags: Short Communication Source Type: research
Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 24, 2023 Category: Allergy & Immunology Source Type: research
Repeated mild traumatic brain injury in mice elicits long term innate immune cell alterations in blood, spleen, and brain
Mild traumatic brain injury is an insidious event whereby the initial injury leads to ongoing secondary neuro- and systemic inflammation through various cellular pathways lasting days to months after injury. Here, we investigated the impact of repeated mild traumatic brain injury (rmTBI) and the resultant systemic immune response in male C57B6 mice using flow cytometric methodology on white blood cells (WBCs) derived from the blood and spleen. Isolated mRNA derived from spleens and brains of rmTBI mice was assayed for changes in gene expression at one day, one week, and one month following the injury paradigm. (Source: Jou...
Source: Journal of Neuroimmunology - May 16, 2023 Category: Allergy & Immunology Authors: Jared A. Smith, Tyler Nguyen, Sonali Karnik, Brittany Davis, Mohammed H. Al-Juboori, Melissa A. Kacena, Alexander G. Obukhov, Fletcher A. White Source Type: research
Pediatric anti-NMDA-receptor autoimmune encephalitis in siblings: Developmental, Electrophysiologic, and genetic implications
Anti-NMDAR encephalitis is a leading cause of autoimmune encephalitis in children. Untreated disease can lead to long-term neurological disability. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 15, 2023 Category: Allergy & Immunology Authors: Albert Aboseif, Karlo Toljan, Ahmad Mahadeen, Andrew Zeft, Ahsan N. Moosa, Elia Pestana-Knight, Aaron Abrams Tags: Short Communication Source Type: research
TREM2, microglial and ischemic stroke
Ischemic stroke (IS) is a leading cause of morbidity and mortality worldwide. Immunity and inflammation are key factors in the pathophysiology of IS. The inflammatory response is involved in all stages of stroke, and microglia are the predominant cells involved in the post-stroke inflammatory response. Resident microglia are the main immune cells of the brain and the first line of defense of the nervous system. After IS, activated microglia can be both advantageous and detrimental to surrounding tissue; they can be divided into the harmful M1 types or the neuro-protective M2 type. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 15, 2023 Category: Allergy & Immunology Authors: Hongxia Wang, Xiaoling Li, Qi Wang, Jialiang Ma, Xiaohong Gao, Manxia Wang Tags: Review Article Source Type: research
Intradermal AQP4 peptide immunization induces clinical features of neuromyelitis optica spectrum disorder in mice
We challenged to create a mouse model of neuromyelitis optica spectrum disorder (NMOSD) induced by AQP4 peptide immunization. Intradermal immunization with AQP4 p201 –220 peptide induced paralysis in C57BL/6 J mice, but not in AQP4 KO mice. AQP4 peptide-immunized mice showed pathological features similar to NMOSD. Administration of anti-IL-6 receptor antibody (MR16–1) inhibited the induction of clinical signs and prevented the loss of GFAP/AQP4 and deposit ion of complement factors in AQP4 peptide-immunized mice. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 15, 2023 Category: Allergy & Immunology Authors: Kenichi Serizawa, Shota Miyake, Yoshichika Katsura, Keigo Yorozu, Mitsue Kurasawa, Haruna Tomizawa-Shinohara, Hideyuki Yasuno, Yoshihiro Matsumoto Source Type: research
A metabolome-wide Mendelian randomization study prioritizes potential causal circulating metabolites for multiple sclerosis
To prioritize circulating metabolites that likely play causal roles in the pathogenesis of multiple sclerosis (MS). Two-sample Mendelian randomization analysis was performed to estimate the causal effects of 571 circulating metabolites on the risk of MS. Genetic instruments for circulating metabolites were obtained from three previous genome-wide association studies (GWAS) of the blood metabolome (N = 7824; 24,925; and 115,078; respectively), while genetic associations with MS were from a large GWAS by the International Multiple Sclerosis Genetics Consortium (14,802 cases and 26,703 control). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 11, 2023 Category: Allergy & Immunology Authors: Angela Ge, Yitang Sun, Thaddaeus Kiker, Yanjiao Zhou, Kaixiong Ye Source Type: research
Repeated stress-induced crosstalk between the sympathetic nervous system and mast cells contributes to delayed cutaneous wound healing in mice
The study identifies a link between the neuroimmune interaction and the impairment of wound healing induced by repeated stress. Stress increased mast cell mobilization and degranulation, levels of IL-10, and sympathetic reinnervation in mouse wounds. In contrast to mast cells, macrophage infiltration into wounds was significantly delayed in stressed mice. Chemical sympathectomy and the blockade of mast cell degranulation reversed the effect of stress on skin wound healing in vivo. In vitro, high epinephrine levels stimulated mast cell degranulation and IL-10 release. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 10, 2023 Category: Allergy & Immunology Authors: Bruna Romana-Souza, Lin Chen, Luisa A. DiPietro Source Type: research
Microglia activation mediates circadian rhythm disruption-induced cognitive impairment in mice
In this study, we investigated whether microglia are involved in CRD-induced cognitive decline. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 8, 2023 Category: Allergy & Immunology Authors: Dongli Meng, Mengzhe Yang, Huiliang Zhang, Lun Zhang, Yi Liu, Yi Zeng, Bo Yang, Xiaochuan Wang, Yu Chen, Rong Liu Source Type: research
Self-delivering mRNA inhibitors of MK2 improve outcomes after spinal cord injury
Functional recovery and tissue damage after spinal cord injury (SCI) are influenced by secondary damage mechanisms, including inflammation. The inflammatory response after SCI relies on a variety of cell types with both protective and cytotoxic functions. The macrophage derived MAPK-activated protein kinase 2 has been described as a critical regulator of inflammation with detrimental function after SCI. Targeted modification of inflammatory effector molecules after SCI faces challenges of optimal timing, dosage and location of administration. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 6, 2023 Category: Allergy & Immunology Authors: Justin J. Page, Jose Rosas Almanza, Shuana Xiong, Veenu Aishwarya, Antje Kroner Source Type: research
Self-delivering mRNA inhibitors of MK2 improve outcome after spinal cord injury
Functional recovery and tissue damage after spinal cord injury (SCI) are influenced by secondary damage mechanisms, including inflammation. The inflammatory response after SCI relies on a variety of cell types with both protective and cytotoxic functions. The macrophage derived MAPK-activated protein kinase 2 has been described as a critical regulator of inflammation with detrimental function after SCI. Targeted modification of inflammatory effector molecules after SCI faces challenges of optimal timing, dosage and location of administration. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 6, 2023 Category: Allergy & Immunology Authors: Justin J. Page, Jose Rosas Almanza, Shuana Xiong, Veenu Aishwarya, Antje Kroner Source Type: research
Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 4, 2023 Category: Allergy & Immunology Source Type: research
