Ferroptosis as a mechanism of oligodendrocyte loss and demyelination in experimental autoimmune encephalomyelitis
Ferroptosis, distinct from necrosis, autophagy and apoptosis, is a unique form of regulated cell death ，and is a potential pathogenic mechanism of neuronal loss and defunction in many neurodegenerative disorders. Recent studies have shown a presence of iron deposition in the central nervous system (CNS) of patients with multiple sclerosis (MS). However, whether ferroptosis is involved in the pathog enesis of MS remains unclear. In the present study, we tested certain classical biomarkers of ferroptosis in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS, to substantiate ...
Source: Journal of Neuroimmunology - October 27, 2022 Category: Allergy & Immunology Authors: Xinyu Li, Yaojuan Chu, Rui Ma, Mengmeng Dou, Silu Li, Yifan Song, Ying Lv, Lin Zhu Source Type: research
K index utility as diagnostic and prognostic biomarker in the assessment of patients with suspected Multiple Sclerosis
The aim of the present study is to evaluate the composite role of k index in the initial assessment of Multiple Sclerosis (MS) patients and to select useful cut-offs exportable in clinical practice. We analysed CSF/serum samples of 140 patients and followed-up the CIS/MS subgroup for 7 years. Our results suggest κ index as a quantitative diagnostic and prognostic biomarker in MS, significantly associated to baseline lesion load and to successive clinical course. We propose k index ≥106 as a prognostic cut-off to select patients at major risk of relapse, potentially influenci ng initial therapeutic decisions. (Source:...
Source: Journal of Neuroimmunology - October 27, 2022 Category: Allergy & Immunology Authors: Claudia Cutell è, Claudia Balducci, Diletta Cereda, Maria Letizia Fusco, Davide Iacobucci, Jacopo Perugini, Fiammetta Pirro, Rinaldo Brivio, Davide Paolo Bernasconi, Carlo Ferrarese, Maura Frigo, Guido Cavaletti Source Type: research
Endothelial cell activation by interleukin-1 and extracellular matrix laminin-10 occurs via the YAP signalling pathway
Laminin-10 (LM-10) is a key regulator of blood-brain barrier (BBB) repair after hypoxia and inflammation. Here we investigated the signalling mechanisms regulated by LM-10 in human brain endothelial cell line hCMEC/D3 in response to interleukin(IL)-1beta( β) in vitro. LM-10 promoted endothelial proliferation and repair of an endothelial monolayer after scratch injury, and upregulated IL-1β-induced ICAM-1 and VCAM-1 expression. IL-1β and LM-10 regulated YAP signalling pathway in endothelial cells leading to differential expression of YAP target gen es, ctgf and serpine-1, providing evidence that the YAP signalling pathwa...
Source: Journal of Neuroimmunology - October 27, 2022 Category: Allergy & Immunology Authors: Hannah Thurgur, Jeffrey Penny, Emmanuel Pinteaux Source Type: research
Cholesterol dysregulation in peripheral blood mononuclear cells of Alzheimer's disease
Cholesterol and the immune system are involved in Alzheimer's Disease (AD). To investigate the relations among them, we compared the cholesterol content in peripheral blood mononuclear cells (PBMC) of cognitively healthy controls and patients with mild cognitive impairment (MCI) and AD in two independent samples.Free cholesterol content of PBMC was lower in MCI and AD patients, and was modulated by APOE genotype. A decrease of CD8+ and an increase of CD16+ was also found in AD patients.These results suggest that cholesterol levels in PBMCs may represent an early signature of the disease and support the involvement of immun...
Source: Journal of Neuroimmunology - October 27, 2022 Category: Allergy & Immunology Authors: A. Mart ín-Montes, M. Recuero, I. Sastre, E. Vilella-Cuadrada, M. Rosich-Estragó, M. Atienza, J.L. Cantero, A. Frank-García, M.J. Bullido Source Type: research
Primary angiitis of the central nervous system as a mimic of multiple sclerosis: A case report
Primary angiitis of the central nervous system is a rare inflammatory vasculopathy and it is a difficult diagnosis to make because of its kaleidoscopic presentation and its multiple mimics, including multiple sclerosis. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 25, 2022 Category: Allergy & Immunology Authors: Eduardo Macedo de Souza Tieppo, Tom ás Fraga Ferreira da Silva, Roger Santana de Araujo, Guilherme Diogo Silva, Vitor Ribeiro Paes, Carolina de Medeiros Rimkus, Gisela Tinone, Samira Apóstolos Pereira, Dagoberto Callegaro Tags: Short Communication Source Type: research
Neurosarcoidosis: A call to arms
Neurosarcoidosis arises when a patient with systemic sarcoidosis either develops neurological involvement, or when the nervous system is the first or only organ manifestation of sarcoidosis. The protean ways in which neurosarcoidosis can present in the nervous system means the astute clinician needs to be alert to the possibility and have a systematic approach to diagnosis and treatment. Failure to consider neurosarcoidosis as a diagnostic possibility, or the limitations related to obtaining a tissue diagnosis, can result in serious morbidity (Bradshaw et al., 2021). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 18, 2022 Category: Allergy & Immunology Authors: Todd A. Hardy, David B. Clifford Source Type: research
Sarcoidosis and obsessive-compulsive symptoms
Autoimmune obsessive-compulsive disorder (OCD) in the context of pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS) has been observed for decades. The first cases of autoimmune OCD in adulthood were recently described. An association between obsessive-compulsive symptoms (OCS) and systemic autoimmune diseases in the form of connective tissue disease has also been reported. However, whether an association exists between OCD and sarcoidosis is unknown. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 17, 2022 Category: Allergy & Immunology Authors: Dominique Endres, Bj örn C. Frye, Andrea Schlump, Hanna Kuzior, Bernd Feige, Kathrin Nickel, Horst Urbach, Miriam A. Schiele, Katharina Domschke, Benjamin Berger, Oliver Stich, Nils Venhoff, Harald Prüss, Ludger Tebartz van Elst Tags: Short Communication Source Type: research
Encephalitis, myocarditis, and thrombocytopenia after COVID-19 mRNA vaccination: Clinical and pathophysiological considerations
COVID-19 vaccination has been associated with rare neurological, cardiac and hematological complications but their causal relationship is not yet fully established. We have read with interest the paper published in Journal of Neuroimmunology (Asaduzzaman et al., 2022) concerning, a 15-year-old girl who developed the following symptomatology after the second dose of Pfizer BioNTech (BNT162b2) COVID-19 vaccine: Fever and diarrhea 1 day after receiving the vaccine, marked thrombocytopenia during the initial blood count examination, symptoms and signs suggesting encephalopathy such as carpopedal spasm in both hands, altered...
Source: Journal of Neuroimmunology - October 15, 2022 Category: Allergy & Immunology Authors: Nicholas G. Kounis, Virginia Mplani, Periklis Dousdampanis, Panagiotis Plotas, Ioanna Koniari Tags: Letter to the Editor Source Type: research
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease: Presentation and outcomes of adults at a single center
Background/Introduction.Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a chronic demyelinating disorder that has been increasingly recognized since the serum antibody became commercially available in 2017. The most common clinical presentation is optic neuritis, and first line acute treatment is intravenous (IV) steroids. However, there are many questions that remain unanswered. For clinicians and patients, the primary question is whether relapses will occur and whether to treat with chronic therapy. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 14, 2022 Category: Allergy & Immunology Authors: Paige Sutton, Michael W. Lutz, F. Lee Hartsell, Dorlan Kimbrough, N. Troy Tagg, Mark Skeen, Nicholas M. Hudak, Christopher Eckstein, Suma Shah Source Type: research
Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 13, 2022 Category: Allergy & Immunology Source Type: research
Treatment response and complications during management of Pott's spine
The global incidence of TB in 2016 was 10.4 million and India accounts for a quarter of the global burden of TB. It is estimated that there are 2.79 million people with TB in India. About 10% of extra pulmonary TB involves bone and joints. Spinal TB accounts for half the cases of skeletal TB. The incidence of spinal TB is 1 –4% total TB cases, then it is estimated that only in India approximately 60,000 spinal TB cases exist.To report the pattern of recovery and predictors of outcome of Pott's spine. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 10, 2022 Category: Allergy & Immunology Authors: Usha K. Misra, Siddharth Warrier, Jayantee Kalita, Abhilasha Tripathi, Sunil Kumar Source Type: research
Sex-dependent neuro-deconvolution analysis of Alzheimer's disease brain transcriptomes according to CHI3L1 expression levels
Glial activation and related neuroinflammatory processes play a key role in the aging and progression of Alzheimer's disease (AD). CHI3L1/ YKL40 is a widely investigated chitinase in neurodegenerative diseases and recent studies have shown its involvement in aging and AD. Nevertheless, the biological function of CHI3L1 in AD is still unknown. Here, we collected microarray datasets from the National Center for Biotechnology Information (NCBI) brain samples of not demented healthy controls (NDHC) who died from causes not attributable to neurodegenerative disorders (n = 460), and of deceased patients suffering from Alzhe...
Source: Journal of Neuroimmunology - October 8, 2022 Category: Allergy & Immunology Authors: Cristina Sanfilippo, Paola Castrogiovanni, Rosa Imbesi, Giuseppe Musumeci, Michele Vecchio, Giovanni Li Volti, Daniele Tibullo, Giuseppe Broggi, Rosario Caltabiano, Martina Ulivieri, Maria Kazakova, Rosalba Parenti, Nunzio Vicario, Francesco Fazio, Michel Source Type: research
Enrichment of serum IgG4 in MuSK myasthenia gravis patients
Muscle-specific kinase (MuSK) myasthenia gravis (MG) is a neuromuscular autoimmune disease belonging to a growing group of IgG4 autoimmune diseases (IgG4-AIDs), in which the majority of pathogenic autoantibodies are of the IgG4 subclass. The more prevalent form of MG with acetylcholine receptor (AChR) antibodies is caused by IgG1 –3 autoantibodies. A dominant role for IgG4 in autoimmune disease is intriguing due to its anti-inflammatory characteristics. It is unclear why MuSK autoantibodies are predominantly IgG4. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 7, 2022 Category: Allergy & Immunology Authors: Dana L.E. Vergoossen, Annabel M. Ruiter, Kevin R. Keene, Erik H. Niks, Martijn R. Tannemaat, Ellen Strijbos, Alexander F. Lipka, Els C. Jol van der Zijde, Maarten J.D. van Tol, Jaap A. Bakker, Brigitte A. Wevers, Elisabet Westerberg, L úcia S. Borges, Ol Tags: Short Communication Source Type: research
Sarcoidosis, granulomas and myopathy syndromes: A clinical-pathology review
Muscle involvement in sarcoidosis is common by pathologic analysis, but symptomatic disorders are less frequent. Sarcoidosis-related muscle pathology includes non-caseating granulomas, muscle fiber changes that are diffuse or anatomically related to granulomas, and perimysial connective tissue with histiocyte-associated damage. The mechanisms by which granulomas form, enlarge and damage muscle tissues are incompletely understood. Sarcoidosis-related clinical syndromes with muscle involvement include: chronic myopathies with proximal weakness; nodular disorders; subacute onset disorders involving proximal or eye muscles; my...
Source: Journal of Neuroimmunology - October 3, 2022 Category: Allergy & Immunology Authors: Mark Garret, Alan Pestronk Source Type: research
GFAP astrocytopathy presenting with profound intracranial hypertension and vision loss
Glial fibrillary acidic protein (GFAP) astrocytopathy is a steroid-responsive autoimmune meningoencephalomyelitis commonly preceded by a viral illness. It is clinically characterized by encephalopathy, myelopathy and papillitis without significant effect on visual acuity. It can be associated with an underlying malignancy or autoimmune condition. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 3, 2022 Category: Allergy & Immunology Authors: Ryan Canissario, Lawrence Samkoff, Maxime Junior Jean, Zo ё Williams, Judy Diep Tags: Short Communication Source Type: research
