Disease modifying therapy in the treatment of tumefactive multiple sclerosis: A retrospective cohort study
Tumefactive multiple sclerosis (TMS) is characterized by large demyelinating brain lesions. This was a retrospective cohort study of 67 patients with TMS between January 2015 –2023, examining different disease modifying therapy impact on expanded disability scale score change at follow-up. Median age was 36 with a female predominance. Mean EDSS was 3.3 ± 2.3 at TMS onset, 2.1 ± 1.9 at year one, and 2.1 ± 1.9 at last follow-up. A multilinear regression mo del found higher presentation EDSS and post-diagnosis non-B-cell high efficacy therapies were each independently associated with higher EDSS at last follo...
Source: Journal of Neuroimmunology - January 31, 2024 Category: Allergy & Immunology Authors: Kristin Galetta, Andrew Siyoon Ham, Anastasia Vishnevetsky, Shamik Bhattacharyya, Farrah J. Mateen Source Type: research
Inhibition of repulsive guidance molecule-a ameliorates compromised blood –spinal cord barrier integrity associated with neuromyelitis optica in rats
We examined whether prophylactic intravenous administration of anti-repulsive guidance molecule-a antibodies (RGMa-Abs) has disease-modifying effects on BSCB dysfunction using an NMO model el icited by peripheral administration of AQP4-Abs to rats. RGMa-Ab treatment attenuated the acute exacerbation of perivascular astrocytopathy in the spinal cord and clinical symptoms, which were highly correlated with neurofilament light chain levels in both the cerebrospinal fluid (CSF) and serum. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 27, 2024 Category: Allergy & Immunology Authors: Masataka Katsu, Misuzu Sekine, Masaharu Tanaka, Yasushi Horai, Airi Akatsuka, Misao Suga, Kazuhiro Kiyohara, Takuya Fujita, Atsushi Sasaki, Toshihide Yamashita Source Type: research
Time to FIRE NORSE: A single acronym for a heterogeneous presentation. Further information from a case series and discussion of the literature.
New-Onset Refractory Status Epilepticus (NORSE) is a rare and severe form of refractory status epilepticus without an apparent underlying cause at presentation or prior history of epilepsy. We aimed to describe the clinical features, etiology, treatment, and outcomes of NORSE in adults in a quaternary-level hospital in Saudi Arabia. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 26, 2024 Category: Allergy & Immunology Authors: Abdulaziz M. Alaskar, Majed A. Aljohani, Sasha Dionisio, Mohammed A. Asiry, Khalid Alqadi Source Type: research
Therapeutic plasma exchange for neuromyelitis optica attacks: Evidence and challenges from a real-world cohort from Brazil
Therapeutic plasma exchange (TPE) can improve disability recovery after neuromyelitis optica spectrum disease (NMOSD) attacks, but its effectiveness and safety in Latin-American patients with access barriers and diverse ethnicity is underexplored. We carried out a retrospective cohort study with NMOSD patients that underwent TPE. 84 NMOSD attacks in 68 patients were evaluated. Despite a median 25-day delay from symptom onset to TPE, 65,5% of patients showed significant improvement. Adverse events occurred in 39% of patients, usually transitory and with no fatalities. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 24, 2024 Category: Allergy & Immunology Authors: Guilherme Mello Ramos de Almeida, Roger Santana de Araujo, Bruno Batitucci Castrillo, Guilherme Diogo Silva, Ida Fortini, Marcia Rubia Rodrigues Gon çalves, Luiz Henrique Martins Castro, Nelson Hidekazu Tatsui, Tarso Adoni, Douglas Kazutoshi Sato, Samira Source Type: research
Diagnostic signatures and immune cell infiltration characteristics in anti-GABABR encephalitis
Anti-gamma-aminobutyric acid B receptor (GABABR) encephalitis is an uncommon form of autoimmune encephalitis associated with a poor prognosis and a high fatality rate. We aim to find diagnostic markers for anti- GABABR encephalitis as well as the effects of immune cell infiltration on this pathology. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 24, 2024 Category: Allergy & Immunology Authors: Shan Qiao, Wen-Yu Zhang, Yun-Fang Xie, Hai-Yun Li, Cai-San Cui, Shu-Xin Tao, Tao Xin, Qi-Ji Liu Source Type: research
Mycophenolate mofetil for the long-term treatment of HTLV-1 associated myelopathy: A case report
We present a woman with rapidly-progressive HAM/TSP with significant, sustained clinical improvement following initiation of mycophenolate mofetil (MMA). Peripheral blood mononuclear cells from the patient, her asymptomatic carrier husband and eight healthy controls were isolated. Frequencies of T-cell populations upon exposure to low and high MMA concentrations and differences in proliferation were analyzed using flow cytometry and a CSFE-proliferation assay. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 22, 2024 Category: Allergy & Immunology Authors: Marta Sanz, Sofia Chernet, John Shymansky, Alexandra Mandel, Alisha Chitrakar, Henry J. Kaminski, Pritha Ghosh, Natalia Soriano-Sarabia Tags: Short Communication Source Type: research
Gamma-oryzanol attenuates lipopolysaccharide-induced cognitive impairment by modulation of hippocampal inflammatory response and glial activation in mice
Systemic inflammation can cause chronic neuroinflammation, which is a significant risk factor for neurodegenerative disorders. Therefore, anti-inflammatory agents that reduce peripheral inflammation are potential targets for the prevention or treatment of these debilitating diseases. In the present study, we investigated whether gamma-oryzanol (ORY) could protect against chronic neuroinflammation induced by lipopolysaccharide (LPS) in adult male mice. Mice were injected with LPS (0.75 mg/kg/day) or saline for 7 consecutive days and orally received ORY (100 mg/kg) or vehicle for 14 days (7 days before LPS injection...
Source: Journal of Neuroimmunology - January 18, 2024 Category: Allergy & Immunology Authors: Shiva Zeini, Nahid Davoodian, Seyed Abdollah Mousavi Source Type: research
Cerebellar leptomeningeal enhancement: An imaging finding of rapidly progressive Purkinje cell cytoplasmic autoantibody type 1 paraneoplastic cerebellar syndrome
This report introduces an imaging finding, cerebellar leptomeningeal enhancement, which was observed in all three cases at early stages. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 18, 2024 Category: Allergy & Immunology Authors: Smathorn Thakolwiboon, Jenny Linnoila, Sean J. Pittock, Divyanshu Dubey, Anastasia Zekeridou Tags: Short Communication Source Type: research
Altered immune co-inhibitory receptor expression and correlation of LAG-3 expression to disease severity in NMOSD
Co-inhibitory receptors (CIR)s regulate T cell-mediated immune responses and growing evidence links co-inhibitory receptors to the progression of neuroimmunological diseases. We studied the expression levels of CIRs: TIM-3, TIGIT, PD-1 and LAG-3 in the peripheral blood mononuclear cells (PBMCs) of 30 patients with Neuromyelitis optica spectrum disorder (NMOSD), 11 Multiple sclerosis (MS) patients and 31 Healthy controls (HC). We found that the mRNA expression levels of TIM-3 were significantly increased in NMOSD compared with HC, and increased LAG-3 surface protein expression was also observed on T-cells of NMOSD patients....
Source: Journal of Neuroimmunology - January 17, 2024 Category: Allergy & Immunology Authors: Nitsan Haham, Omri Zveik, Ariel Rechtman, Livnat Brill, Adi Vaknin-Dembinsky Source Type: research
Incident anti-LGI1 autoimmune encephalitis during dementia with Lewy bodies: When Occam razor is a double-edged sword
We report a case of DLB with superimposed anti-LGI1 encephalitis, emphasizing the importance of thorough diagnostic reasoning beyond the simplest explanation amid distinct clinical cues. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 13, 2024 Category: Allergy & Immunology Authors: Denise Cerne, Mattia Losa, Pietro Mattioli, Anastasia Lechiara, Giacomo Rebella, Luca Roccatagliata, Dario Arnaldi, Angelo Schenone, Silvia Morbelli, Luana Benedetti, Federico Massa Tags: Short Communication Source Type: research
Association of peripheral immune activation with amyotrophic lateral sclerosis and Parkinson's disease: A systematic review and meta-analysis
Recent studies have revealed the link between immune activation and neurodegenerative diseases. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 12, 2024 Category: Allergy & Immunology Authors: Han Wang, Yi-Ti Liu, Yan-Ling Ren, Xiao-Yan Guo, Yi Wang Tags: Review Article Source Type: research
Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 10, 2024 Category: Allergy & Immunology Source Type: research
Efficacy and safety of low- and ultralow-dose rituximab in neuromyelitis optica spectrum disorder
Rituximab effectively targets B cells and reduces relapses in neuromyelitis optica spectrum disorder (NMOSD). But the ideal dosage and treatment intervals remain unanswered. We aimed to assess the efficacy and safety of low and ultralow-dose rituximab in NMOSD. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 8, 2024 Category: Allergy & Immunology Authors: Chengyi Zhang, Rui Liu, Bin Gao, Ting Li, Huabing Wang, Tian Song, Yuetao Ma, Wangshu Xu, Yun Liu, Xinghu Zhang, De-Cai Tian, Chunsheng Yang, Kaibin Shi Source Type: research
Peripheral blood regulatory B and T cells are decreased in patients with focal epilepsy
Patients with focal epilepsy of unknown cause (FEoUC) may display T cell infiltration in post-surgery brain specimens and increased serum levels of pro-inflammatory cytokines produced by B and T cells, indicating potential involvement of adaptive immunity. Our study aimed to investigate the peripheral blood distribution of B and T cell subgroups to find clues supporting the distinct organization of adaptive immunity in FEoUC. Twenty-two patients with FEoUC and 25 age and sex matched healthy individuals were included. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 8, 2024 Category: Allergy & Immunology Authors: Elif Sanli, Nermin Gorkem Sirin, Cem Ismail Kucukali, Betul Baykan, Canan Aysel Ulusoy, Nerses Bebek, Vuslat Yilmaz, Erdem Tuzun Source Type: research
SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates
We examined the histopathological changes in the olfactory mucosa of cynomolgus and rhesus macaque models of SARS-CoV-2 infection. SARS-CoV-2 infection induced severe inflammatory changes in the olfactory mucosa. A major histocompatibility complex (MHC) class II molecule, HLA-DR was expressed in macrophage and supporting cells, and melanocytes were increased in olfactory mucosa. Supporting cells and olfactory neurons were infected, and SARS-CoV-2 N protein was detected in the axons of olfactory neurons and in olfactory bulbs. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 8, 2024 Category: Allergy & Immunology Authors: Shino Shimizu, Misako Nakayama, Cong Thanh Nguyen, Hirohito Ishigaki, Yoshinori Kitagawa, Fumihiko Yasui, Yoshiki Yagi, Tomoe Kusayanagi, Michinori Kohara, Yasushi Itoh, Ichiro Tojima, Hideaki Kouzaki, Takeshi Shimizu Source Type: research
