Ferroptosis participated in hippocampal neuroinflammation damage of in offspring rats after maternal sleep deprivation
Sleep deprivation during pregnancy has important effects on the pregnant woman herself and her offspring, and some studies have found that neuroinflammation in her offspring is important, but the mechanisms are poorly understood. To investigate the involvement of ferroptosis in cognitive impairment due to hippocampal neuroinflammation in offspring rats after maternal sleep deprivation. SD rats exposed to late gestational sleep deprivation were deprived of sleep for 72 h. Their offspring were given the ferroptosis inhibitor liproxstatin-1 (5 mg/kg) intraperitoneally 3 days after birth. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 16, 2023 Category: Allergy & Immunology Authors: Jing Lv, Siyuan Xu, Chen Meng, Yu Wang, Liu Ji, Xiaoyan Li, Xianyu Wang, Qing Li Source Type: research
Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 15, 2023 Category: Allergy & Immunology Source Type: research
Microglial depletion exacerbates motor impairment and dopaminergic neuron loss in a 6-OHDA model of Parkinson's disease
6-hydroxydopamine (6-OHDA) is a common neurotoxin used to induce Parkinson's disease (PD) in mice, exerting neurotoxic effects through the production of reactive oxygen species and microglial activation. However, the role of microglia in PD is still not clear, with contradictory reports showing neuroprotection or exacerbation of neuronal death. Microglial depletion aggravates motor coordination impairments and reduces tyrosine hydroxylase positive neurons in the substantia nigra pars compacta. Moreover, MeCP2 and Adora1 genes expression were downregulated, suggesting they may be involved in the neurodegenerative process. (...
Source: Journal of Neuroimmunology - January 13, 2023 Category: Allergy & Immunology Authors: Carolina Parga Martins Pereira, Jos é Francis-Oliveira, Monique Patricio Singulani, Ana Flávia Fernandes Ferreira, Luiz Roberto G. Britto Source Type: research
Ketorolac and (-)-Epicatechin change retinal GFAP and NRF2 expression on hyperglycemic CD1 mice
Our objective was to determine whether (-)-Epicatechin administered alone or simultaneously with topical Ketorolac decreased the relative expression of GFAP and modulated the response of Nrf2 in a mouse model with induced hyperglycemia. We found that GFAP and Nrf2 decreased in the groups that received treatments alone or simultaneous during 8 weeks; even when the effect on the Nrf2 was not pronounced, it showed a higher concentration when GFAP decreased. Our results suggest a protective effect of Ketorolac and (-) - Epicatechin, which seem to limit the preclinical retinal damage caused by inflammation in hyperglycemia. ...
Source: Journal of Neuroimmunology - January 12, 2023 Category: Allergy & Immunology Authors: Selma Alin Somilleda-Ventura, Ruth Mery L ópez-Mayorga, Eduardo Meaney-Mendiolea, Angel Ivan Orlando Rubio-Gayosso, Héctor Javier Pérez-Cano, Guillermo Manuel Ceballos-Reyes, Virgilio Lima-Gómez Source Type: research
3D in vitro modelling of human patient microglia: A focus on clinical translation and drug development in neurodegenerative diseases
Microglia have an increasingly well-recognised role in the pathogenesis of neurodegenerative diseases, thereby becoming attractive therapeutic targets. However, the development of microglia-targeted therapeutics for neurodegeneration has had limited success. This stems partly from the lack of clinically relevant microglia model systems. To circumvent this translational gap, patient-derived microglial cell models established using conventional 2D in vitro techniques have emerged. Though promising, these models lack the microenvironment and multicellular interactions of the brain needed to maintain microglial homeostasis. (S...
Source: Journal of Neuroimmunology - January 11, 2023 Category: Allergy & Immunology Authors: Carla Cun í-López, Romal Stewart, Anthony R. White, Hazel Quek Source Type: research
Iron metabolism in non-anemic myasthenia gravis patients: A cohort study
This study was conducted to determined clinical factors including iron metabolism parameters correlated with disease severity and future outcome in non-anemic immunotherapy-na ïve MG patients first receiving immunotherapy. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 9, 2023 Category: Allergy & Immunology Authors: Ke Li, Li' ’an Hou, Ying Tan, Yangyu Huang, Jiayu Shi, Jianhua Han, Jingwen Yan, Yuzhou Guan, Liying Cui Source Type: research
Role of soluble forms of follicular helper T-cell membrane molecules in the pathogenesis of myasthenia gravis
This study examined the role of Tfh and Treg associated molecules also known as checkpoint molecules, their ligands, and IL-21 in myasthenia gravis (MG) pathogenesis. Serum levels of sPD-1, sPD-L1, sICOS, sICOSLG, sCTLA4, and IL-21 were measured in 39 patients with acetylcholine receptor (AChR) antibody-positive generalized MG and 27 controls. sPD-1 and IL-21 levels were higher in MG patients than in controls. Additionally, sPD-1 levels correlated positively with the levels of IL-21, sICOSLG, sCTLA4, and AChR antibody titers. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 1, 2023 Category: Allergy & Immunology Authors: Hiroyuki Akamine, Akiyuki Uzawa, Yuta Kojima, Yukiko Ozawa, Manato Yasuda, Yosuke Onishi, Satoshi Kuwabara Source Type: research
Calcitriol modulate post-ischemic TLR signaling pathway in ischemic stroke patients
This study aimed to determine the modulat ory effects of calcitriol hormone on post-ischemic immunity response. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 26, 2022 Category: Allergy & Immunology Authors: Saeedeh Tajalli-Nezhad, Salimeh Mohammadi, Mohammad Ali Atlasi, Mahdi Kheiran, Sepideh Etehadi Moghadam, Homayoun Naderian, Abolfazl Azami Tameh Source Type: research
AMPAR autoimmunity: Neurological and oncological accompaniments and co-existing neural autoantibodies
α -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) encephalitis is rare but treatable. We reviewed the clinical and autoantibody profiles of 52 AMPAR-IgG-positive patients (median age 48 years [range 12–81]; 38 female) identified at the Mayo Clinic neuroimmunology laborator y. Main presentation was encephalitis; symptoms other than encephalitis associated with co-existing antibodies (p = 0.004). A tumor was found in 33/44; mostly thymoma. Most patients had partial (14/29) or complete (11/29) immunotherapy response. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 23, 2022 Category: Allergy & Immunology Authors: Jennifer A. McCombe, Cecilia Zivelonghi, Nisa Vorasoot, Masoud Majed, Eoin P. Flanagan, Divyanshu Dubey, Sean J. Pittock, Andrew McKeon, Anastasia Zekeridou Tags: Short Communication Source Type: research
Atypical myelin oligodendrocyte glycoprotein antibody –associated optic neuritis and acute demyelinating polyneuropathy after SARS-CoV-2 infection: Case report and literature review
We describe the case of a 74 years-old patient who developed a Myelin Oligodendrocyte Glycoprotein (MOG) antibody-associated unilateral retrobulbar optic neuritis a few weeks after paucisymptomatic COVID-19 disease and, subsequently, after the resolution of the optic neuritis, an acute inflammatory demyelinating polyneuropat hy. So far, no cases of these two neurological manifestations have been reported in the same patient. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 22, 2022 Category: Allergy & Immunology Authors: Francesca Bosello, Damiano Marastoni, Francesca Benedetta Pizzini, Chiara Zaffalon, Andrea Zuliani, Giulia Turri, Sara Mariotto, Erika Bonacci, Emilio Pedrotti, Massimiliano Calabrese Tags: Short Communication Source Type: research
Ocrevus reduces TH40 cells, a biomarker of systemic inflammation, in relapsing multiple sclerosis (RMS) and in progressive multiple sclerosis (PMS)
Treating MS has been difficult. One successful drug is Ocrelizumab (anti-CD20), used for the chronic relapsing MS (RMS) and the progressive MS (PMS) forms. TH40 cells are pathogenic effector T cells that increase in percentage and numbers during chronic inflammation. Here we show that in the earliest MS course, clinically isolated syndrome (CIS), TH40 cells expand in number. In PMS TH40 cell numbers remain expanded demonstrating sustained chronic inflammation. In RMS TH40 cells were found in CSF and express CD20. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 6, 2022 Category: Allergy & Immunology Authors: Christian Curran, Gisela Vaitaitis, Dan Waid, Timothy Volmer, Enrique Alverez, David H. Wagner Source Type: research
Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors
Central nervous system (CNS) tumors are the most common type of solid tumors in children and the leading cause of cancer deaths in ages 0 –14. Recent advances in the field of tumor biology and immunology have underscored the disparate nature of these distinct CNS tumor types. In this review, we briefly introduce pediatric CNS tumors and discuss various components of the TME, with a particular focus on myeloid cells. Although most st udies regarding myeloid cells have been done on adult CNS tumors and animal models, we discuss the role of myeloid cell heterogeneity in pediatric CNS tumors and describe how these cells may ...
Source: Journal of Neuroimmunology - December 5, 2022 Category: Allergy & Immunology Authors: Sujay Kalathoor, Sakthi Rajendran, Alessandro Canella, Raju Raval, Timothy P. Cripe, Elaine R. Mardis, Prajwal Rajappa Tags: Review Article Source Type: research
Characteristic cerebrospinal fluid findings in immune checkpoint inhibitor-related peripheral neuropathy: A case report
Although immune checkpoint inhibitors (ICIs) are widely used to treat unresectable malignant tumors, they can cause undesirable side effects called immune-related adverse events, including neurological toxicities. Here, we describe a case of ICI-related peripheral neuropathy (irPN) with characteristic cerebrospinal fluid (CSF) findings. In addition to pleocytosis and increased protein levels, the present case showed increased levels of CSF soluble interleukin-2 receptor (sIL-2R), IL-6, and IL-10, suggesting activated T cell-related autoimmunity. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 5, 2022 Category: Allergy & Immunology Authors: Sho Wako, Ryotaro Ikeguchi, Kunio Toda, Masaki Kobayashi, Ryujin Miyata, Hidekazu Kuramochi, Atsuhiro Ichihara, Yuko Shimizu, Kazuo Kitagawa Tags: Short Communication Source Type: research
Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - November 28, 2022 Category: Allergy & Immunology Source Type: research
Brain stem encephalitis is a rare complication of COVID-19
Here, we describe the clinical phenotype of SARS-CoV-2-related CNS disease and evaluate the SARS-CoV-2 antibody index as a tool to differentiate between a direct (viral) and indirect etiology. Out of>4000 hospitalized patients with COVID-19, we included 13 patients with neurological symptoms with suspicion of neuroinflammation. On clinical grounds, eight were classified as having a possible/probable relationship between neurological symptoms and COVID-19. A clinically distinctive phenotype of brainstem and cerebellar symptoms was seen in 6/8 patients. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - November 27, 2022 Category: Allergy & Immunology Authors: Marc C. Shamier, Yvette S. Crijnen, Susanne Bogers, Jeroen W. IJpelaar, Juna M. de Vries, Mathieu van der Jagt, Jochem K.H. Spoor, Jan H. von der Th üsen, Marco W.J. Schreurs, Corine H. GeurtsvanKessel, Maarten J. Titulaer Tags: Short Communication Source Type: research
