Characteristic cerebrospinal fluid findings in immune checkpoint inhibitor-related peripheral neuropathy: A case report

Although immune checkpoint inhibitors (ICIs) are widely used to treat unresectable malignant tumors, they can cause undesirable side effects called immune-related adverse events, including neurological toxicities. Here, we describe a case of ICI-related peripheral neuropathy (irPN) with characteristic cerebrospinal fluid (CSF) findings. In addition to pleocytosis and increased protein levels, the present case showed increased levels of CSF soluble interleukin-2 receptor (sIL-2R), IL-6, and IL-10, suggesting activated T cell-related autoimmunity.

Source: Journal of Neuroimmunology - December 5, 2022 Category: Allergy & Immunology Authors: Sho Wako, Ryotaro Ikeguchi, Kunio Toda, Masaki Kobayashi, Ryujin Miyata, Hidekazu Kuramochi, Atsuhiro Ichihara, Yuko Shimizu, Kazuo Kitagawa Tags: Short Communication Source Type: research