Enrichment of serum IgG4 in MuSK myasthenia gravis patients
Muscle-specific kinase (MuSK) myasthenia gravis (MG) is a neuromuscular autoimmune disease belonging to a growing group of IgG4 autoimmune diseases (IgG4-AIDs), in which the majority of pathogenic autoantibodies are of the IgG4 subclass. The more prevalent form of MG with acetylcholine receptor (AChR) antibodies is caused by IgG1 –3 autoantibodies. A dominant role for IgG4 in autoimmune disease is intriguing due to its anti-inflammatory characteristics. It is unclear why MuSK autoantibodies are predominantly IgG4. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 7, 2022 Category: Allergy & Immunology Authors: Dana L.E. Vergoossen, Annabel M. Ruiter, Kevin R. Keene, Erik H. Niks, Martijn R. Tannemaat, Ellen Strijbos, Alexander F. Lipka, Els C. Jol van der Zijde, Maarten J.D. van Tol, Jaap A. Bakker, Brigitte A. Wevers, Elisabet Westerberg, L úcia S. Borges, Ol Tags: Short Communication Source Type: research
Sarcoidosis, granulomas and myopathy syndromes: A clinical-pathology review
Muscle involvement in sarcoidosis is common by pathologic analysis, but symptomatic disorders are less frequent. Sarcoidosis-related muscle pathology includes non-caseating granulomas, muscle fiber changes that are diffuse or anatomically related to granulomas, and perimysial connective tissue with histiocyte-associated damage. The mechanisms by which granulomas form, enlarge and damage muscle tissues are incompletely understood. Sarcoidosis-related clinical syndromes with muscle involvement include: chronic myopathies with proximal weakness; nodular disorders; subacute onset disorders involving proximal or eye muscles; my...
Source: Journal of Neuroimmunology - October 3, 2022 Category: Allergy & Immunology Authors: Mark Garret, Alan Pestronk Source Type: research
GFAP astrocytopathy presenting with profound intracranial hypertension and vision loss
Glial fibrillary acidic protein (GFAP) astrocytopathy is a steroid-responsive autoimmune meningoencephalomyelitis commonly preceded by a viral illness. It is clinically characterized by encephalopathy, myelopathy and papillitis without significant effect on visual acuity. It can be associated with an underlying malignancy or autoimmune condition. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 3, 2022 Category: Allergy & Immunology Authors: Ryan Canissario, Lawrence Samkoff, Maxime Junior Jean, Zo ё Williams, Judy Diep Tags: Short Communication Source Type: research
Rabies virus isolated from insectivorous bats induces different inflammatory responses in experimental model
Rabies virus (RABV) is a neurotropic virus that causes fatal neuroinflammation in mammals. The insectivorous bat RABV strains are less pathogenic for mice than strains associated with other reservoirs. We characterized the tissue inflammatory response in the CNS of RABV isolated from insectivorous bats. Eptesicus furinalis (EPBRV)-infected mice had a robust inflammatory response and a greater amount of IL-1 β, IL-6 and TNF-α, while Myotis nigricans (MNBRV)-infected mice showed a higher expression of IL-17 and greater activation of IFN-β. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 1, 2022 Category: Allergy & Immunology Authors: Gabriela Hering Motta, Leticia Patr ícia Guimarães, Elaine Raniero Fernandes, F. Fernanda Guedes, Lilian Rose Marques de Sá, Sandriana dos Ramos Silva, Orlando Garcia Ribeiro, Iana Suly Santos Katz Source Type: research
Bladder dysfunction in experimental autoimmune encephalomyelitis reflects clinical severity: A pilot study
Multiple sclerosis (MS) is commonly associated with bladder dysfunction resulting in a progressive loss of voluntary control for urination over time. Here, we used the voided stain on paper (VSOP) method to investigate bladder function in the experimental autoimmune encephalomyelitis (EAE) mouse model of MS. Using the VSOP test, we show that bladder dysfunction reflects pro-inflammatory processes of EAE and severity of clinical EAE symptoms, as characterized by increased urine voided volume per micturition (UVVM) on post-induction day 7 and decreased UVVM on post-induction day 14. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 29, 2022 Category: Allergy & Immunology Authors: Jamshid Faraji, Connor Gustafson, Dennis Bettenson, Hiromitsu Negoro, V. Wee Yong, Gerlinde A.S. Metz Source Type: research
Real-world application of the updated diagnostic criteria for paraneoplastic neurological syndromes
Following recent discoveries, diagnostic criteria for paraneoplastic neurological syndromes (PNS) have been recently updated. However, how the criteria impact PNS diagnosis is still unclear. We retrospectively applied the previously existing 2004 criteria (2004-c) and the updated 2021 diagnostic criteria (2021-c) to 74 patients with suspect PNS. The 2021 criteria were highly sensitive (88%) and specific (80%). There was good concordance between the definite PNS group (2004-c) and the definite plus probable PNS group (2021-c). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 21, 2022 Category: Allergy & Immunology Authors: Lucia Campetella, Claudia Papi, Eleonora Sabatelli, Sofia Marini, Raffaele Iorio Tags: Short Communication Source Type: research
Management of neurosarcoidosis
This is a brief and purposefully practical approach to the therapeutic and rehabilitative management of patients affected by neurological complications of systemic sarcoidosis.The review notes the drugs used and their monitoring, and their role in the series of clinical subgroups identified to form the condition. Treatment guidelines for individual clinical subtypes of the disorder are provided, and the importance of rehabilitative measures and lifestyle changes are emphasised. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 15, 2022 Category: Allergy & Immunology Authors: Desmond P. Kidd Source Type: research
The microglial endocannabinoid system is similarly regulated by lipopolysaccharide and interferon gamma
Perturbation of the endocannabinoid system can have profound effects on immune function and synaptic plasticity. Microglia are one of few cell types with a self-contained endocannabinoid system and are positioned at the interface between the immune system and the central nervous system. Past work has produced conflicting results with respect to the effects of pro-inflammatory conditions on the microglial endocannabinoid system. Thus, we systematically investigated the relationship between the concentration of two distinct pro-inflammatory stimuli, lipopolysaccharide and interferon gamma, on the abundance of components of t...
Source: Journal of Neuroimmunology - September 14, 2022 Category: Allergy & Immunology Authors: Alexander P. Young, Eileen M. Denovan-Wright Source Type: research
Lymphomas mimicking neuroinflammatory diseases – A diagnostic conundrum worth revisiting
Central nervous system (CNS) lymphomas (CNSLs) have varied clinical presentations which can mimic neuroinflammatory disease, leading to a diagnostic dilemma for clinicians. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 14, 2022 Category: Allergy & Immunology Authors: Syed Ali Raza, Madiha Raza, Min Dai, Ammar Husan, James Cotelingam, Hassan AlHussein Tags: Short Communication Source Type: research
Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 13, 2022 Category: Allergy & Immunology Source Type: research
Cladribine treatment for highly active multiple sclerosis: Real-world clinical outcomes for years 3 and 4
Cladribine is an effective immunomodulatory treatment used for relapsing forms of multiple sclerosis (MS). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 5, 2022 Category: Allergy & Immunology Authors: David Magalashvili, Mathilda Mandel, Sapir Dreyer-Alster, Maria Didikin, Gil Harari, Shlomo Flechter, Anat Achiron Source Type: research
Myelin oligodendrocyte glycoprotein associated transverse myelitis following brain abscess: Case report and literature review
We report an unusual case of MOGAD transverse myelitis following a streptococcal brain abscess which has not been previously reported. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 5, 2022 Category: Allergy & Immunology Authors: James Eaton, Megan Rahmlow Tags: Short Communication Source Type: research
The pathophysiology of major depressive disorder through the lens of systems biology: Network analysis of the psycho-immune-neuroendocrine physiome
The psycho-immune-neuroendocrine (PINE) network is a predominantly physiological (metabolomic) model constructed from the literature, inter-linking multiple biological processes associated with major depressive disorder (MDD), thereby integrating putative mechanistic pathways for MDD into a single network. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - September 2, 2022 Category: Allergy & Immunology Authors: Nicolas J.C. Stapelberg, Tuan A. Bui, Verena Mansour, Susannah Johnson, Grace Branjerdporn, Sam Adhikary, Kevin Ashton, Nevin Taylor, John P. Headrick Tags: Review Article Source Type: research
Genetics of neurosarcoidosis
Sarcoidosis is a systemic, inflammatory, granulomatous disease characterized by great variability in organ involvement, clinical course, and severity. While pulmonary manifestations are almost universal, the central and peripheral nervous systems can also be affected. Neurosarcoidosis occurs in ~5 –15% of cases and is among the manifestations with the highest morbidity and mortality. It is known that sarcoidosis has genetic underpinnings and while multiple studies aimed at identifying associations to sarcoidosis susceptibility and prognosis, very few studies have focused on neurosarcoidosis . (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 29, 2022 Category: Allergy & Immunology Authors: Abigail Hardin, Bryan Dawkins, Nathan Pezant, Astrid Rasmussen, Courtney Montgomery Source Type: research
Effect of tacrolimus on soluble costimulatory molecules in patients with refractory myasthenia gravis
To investigate the expression and possible role of soluble costimulatory molecules in the treatment of refractory myasthenia gravis. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - August 28, 2022 Category: Allergy & Immunology Authors: Hui Wu, Lan Chen, Xiaoling Zhou, Yanshi Wu, Yu Yan, Yibei Zhu, Chongbo Zhao, Qun Xue Source Type: research
