Ferroptosis participated in hippocampal neuroinflammation damage of in offspring rats after maternal sleep deprivation

Sleep deprivation during pregnancy has important effects on the pregnant woman herself and her offspring, and some studies have found that neuroinflammation in her offspring is important, but the mechanisms are poorly understood. To investigate the involvement of ferroptosis in cognitive impairment due to hippocampal neuroinflammation in offspring rats after maternal sleep deprivation. SD rats exposed to late gestational sleep deprivation were deprived of sleep for 72  h. Their offspring were given the ferroptosis inhibitor liproxstatin-1 (5 mg/kg) intraperitoneally 3 days after birth.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research