Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - February 4, 2023 Category: Allergy & Immunology Source Type: research
Recurrent encephalopathy associated with pegylated beta-interferon treatment
A 62-year-old woman with a history of multiple sclerosis (MS) presented with recurrent episodes of confusion, dysarthria and gait difficulties. These episodes occurred about 3 days after administration of pegylated interferon-beta-1a (Plegridy®) and resolved spontaneously in around 4 days. The brain MRI scan, laboratory findings and cerebrospinal fluid analysis during these episodes were negative for other causes of encephalopathy. She discontinued treatment with in terferon and was started on teriflunomide, experiencing no recurrence of symptoms. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 30, 2023 Category: Allergy & Immunology Authors: Francisca Ferreira, Daniel Ferreira, Joana Guimar ães, Ricardo Soares-dos-Reis Tags: Short Communication Source Type: research
Tissue-resident memory t cells in the multiple sclerosis BRAIN and their relationship to Epstein-Barr virus infected b cells
Presence of EBV infected B cells and EBV-specific CD8 T cells in the multiple sclerosis (MS) brain suggests a role for virus-driven immunopathology in brain inflammation. Tissue-resident memory (Trm) T cells differentiating in MS lesions could provide local protection against EBV reactivation. Using immunohistochemical techniques to analyse canonical tissue residency markers in postmortem brains from control and MS cases, we report that CD103 and/or CD69 are mainly expressed in a subset of CD8+ T cells that intermingle with and contact EBV infected B cells in the infiltrated MS white matter and meninges, including B-cell f...
Source: Journal of Neuroimmunology - January 25, 2023 Category: Allergy & Immunology Authors: Barbara Serafini, Barbara Rosicarelli, Caterina Veroni, Francesca Aloisi Source Type: research
The case report of AQP4 and MOG IgG double positive NMOSD treated with subcutaneous Ofatumumab
Neuromyelitis optica spectrum disorders (NMOSD) is an autoimmune demyelinating disease with IgG against aquaporin 4 (AQP4) in more than two thirds of patients. Anti-myelin-oligodendrocyte glycoprotein (MOG) antibody is found in some AQP4-negative NMOSD patients and MOG antibody-associated disease (MOGAD) is thought to be distinct from NMOSD. Due to the high disabling nature of NMOSD, treatment strategy on first attack is crucial for good prognosis. Rituximab (RTX), an anti-CD20 monoclonal antibody (mAb), is the first-line treatment for NMOSD. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 25, 2023 Category: Allergy & Immunology Authors: Bin Gou, Ping Yang, Jinzhou Feng, Yongmei Li, Gen Huang, Jiafeng Shi, Lu Wen, Xiuming Guo, Peng Zheng, Gang Yu Tags: Short Communication Source Type: research
The PTEN-associated immune prognostic signature reveals the landscape of the tumor microenvironment in glioblastoma
In this study, we conducted a comprehensive analysis of multiple levels of data, including whole-exome sequencing (WES), transcriptome RNA sequencing, patient survival and immune signatures, to study the relationship between PTEN mutation and TME in GBM. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 24, 2023 Category: Allergy & Immunology Authors: Zhaoming Zhou, Mingyao Lai, Jiayin Yu, Jiangfen Zhou, Qingjun Hu, Juan Li, Hainan Li, Longhua Chen, Lei Wen, Meijuan Zhou, Linbo Cai Tags: Review Article Source Type: research
Genome-wide identification of murine interferon genes in microglial-mediated neuroinflammation in Alzheimer's disease
Interferons play a major role in microglial-mediated neuroinflammation in Alzheimer's disease (AD). We investigated the interferon transcriptome (AD versus non-AD) using N9 and murine microglia. We identified 64 interferon-related differentially expressed genes (DEG) in LPS-stimulated N9 microglia versus control cells, 26 DEG in microglia from 5XFAD versus wild-type mice, with 13 DEG common to both datasets. Network analyses identified potential key mediators (Cxcl10, Ifit3) of the interferon response in AD. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 21, 2023 Category: Allergy & Immunology Authors: Daniel C. Shippy, Tyler K. Ulland Source Type: research
Atypical clinical and novel radiological findings in Susac syndrome: Experience from a large monocentric cohort
Susac syndrome (SuS) is a rare immune-mediated endotheliopathy that affects the brain, retina and inner ear and is characterised by the variable clinical triad of encephalopathy, visual and vestibulocochlear dysfunction. Here, we present clinical and paraclinical data of 19 SuS patients followed at Ghent University Hospital and highlight some atypical clinical and novel radiological findings. Our findings suggest that spinal involvement expands the clinical phenotype of SuS. We further introduce dark blood sequences as a more sensitive technique to detect radiological disease activity in SuS. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 21, 2023 Category: Allergy & Immunology Authors: Cath érine Dekeyser, Alexander Vanhoorne, Dimitri Hemelsoet, Liesbeth Van Hijfte, Julie De Zaeytijd, Veroniek Van Driessche, Helen Van Hoecke, Marijke Miatton, Tineke Van Vrekhem, Leen Maes, Guy Laureys Source Type: research
Dynamics of cachexia-associated inflammatory changes in the brain accompanying intra-abdominal fibrosarcoma growth in Wistar rats
Accumulated data indicate that inflammation affecting brain structures participates in the development of cancer-related cachexia. However, the mechanisms responsible for the induction and progression of cancer-related neuroinflammation are still not fully understood. Therefore, we studied the time-course of neuroinflammation in selected brain structures and cachexia development in tumor-bearing rats. After tumor cells inoculation, specifically on the 7th, 14th, 21st, and 28th day of tumor growth, we assessed the presence of cancer-associated cachexia in rats. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 21, 2023 Category: Allergy & Immunology Authors: Alena Cernackova, Andrej Tillinger, Jozef Bizik, Boris Mravec, Lubica Horvathova Source Type: research
TAM receptor signaling dictates lesion location and clinical phenotype during experimental autoimmune encephalomyelitis
Experimental autoimmune encephalomyelitis (EAE), induced by the adoptive transfer of Th17 cells, typically presents with ascending paralysis and inflammatory demyelination of the spinal cord. Brain white matter is relatively spared. Here we show that treatment of Th17 transfer recipients with a highly selective inhibitor to the TAM family of tyrosine kinase receptors results in ataxia associated with a shift of the inflammatory infiltrate to the hindbrain parenchyma. During homeostasis and preclinical EAE, hindbrain microglia express high levels of the TAM receptor Mer. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 20, 2023 Category: Allergy & Immunology Authors: Ashley Munie Gardner, Jeffrey R. Atkinson, Nicole M. Wilkinson, Andrew D. Jerome, Calli E. Bellinger, Andrew R. Sas, Benjamin M. Segal Source Type: research
Prolonged and intense neuroinflammation after severe traumatic brain injury assessed by cerebral microdialysis with 300 kDa membranes
In this study, a (300 kDa) MD probe was used to measure the levels of cytokines and chemokines in relation to ICP and metabolites. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 16, 2023 Category: Allergy & Immunology Authors: David Cederberg, Edward Visse, Niklas Marklund, Peter Siesj ö Source Type: research
Ferroptosis participated in hippocampal neuroinflammation damage of in offspring rats after maternal sleep deprivation
Sleep deprivation during pregnancy has important effects on the pregnant woman herself and her offspring, and some studies have found that neuroinflammation in her offspring is important, but the mechanisms are poorly understood. To investigate the involvement of ferroptosis in cognitive impairment due to hippocampal neuroinflammation in offspring rats after maternal sleep deprivation. SD rats exposed to late gestational sleep deprivation were deprived of sleep for 72 h. Their offspring were given the ferroptosis inhibitor liproxstatin-1 (5 mg/kg) intraperitoneally 3 days after birth. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 16, 2023 Category: Allergy & Immunology Authors: Jing Lv, Siyuan Xu, Chen Meng, Yu Wang, Liu Ji, Xiaoyan Li, Xianyu Wang, Qing Li Source Type: research
Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - January 15, 2023 Category: Allergy & Immunology Source Type: research
Microglial depletion exacerbates motor impairment and dopaminergic neuron loss in a 6-OHDA model of Parkinson's disease
6-hydroxydopamine (6-OHDA) is a common neurotoxin used to induce Parkinson's disease (PD) in mice, exerting neurotoxic effects through the production of reactive oxygen species and microglial activation. However, the role of microglia in PD is still not clear, with contradictory reports showing neuroprotection or exacerbation of neuronal death. Microglial depletion aggravates motor coordination impairments and reduces tyrosine hydroxylase positive neurons in the substantia nigra pars compacta. Moreover, MeCP2 and Adora1 genes expression were downregulated, suggesting they may be involved in the neurodegenerative process. (...
Source: Journal of Neuroimmunology - January 13, 2023 Category: Allergy & Immunology Authors: Carolina Parga Martins Pereira, Jos é Francis-Oliveira, Monique Patricio Singulani, Ana Flávia Fernandes Ferreira, Luiz Roberto G. Britto Source Type: research
Ketorolac and (-)-Epicatechin change retinal GFAP and NRF2 expression on hyperglycemic CD1 mice
Our objective was to determine whether (-)-Epicatechin administered alone or simultaneously with topical Ketorolac decreased the relative expression of GFAP and modulated the response of Nrf2 in a mouse model with induced hyperglycemia. We found that GFAP and Nrf2 decreased in the groups that received treatments alone or simultaneous during 8 weeks; even when the effect on the Nrf2 was not pronounced, it showed a higher concentration when GFAP decreased. Our results suggest a protective effect of Ketorolac and (-) - Epicatechin, which seem to limit the preclinical retinal damage caused by inflammation in hyperglycemia. ...
Source: Journal of Neuroimmunology - January 12, 2023 Category: Allergy & Immunology Authors: Selma Alin Somilleda-Ventura, Ruth Mery L ópez-Mayorga, Eduardo Meaney-Mendiolea, Angel Ivan Orlando Rubio-Gayosso, Héctor Javier Pérez-Cano, Guillermo Manuel Ceballos-Reyes, Virgilio Lima-Gómez Source Type: research
3D in vitro modelling of human patient microglia: A focus on clinical translation and drug development in neurodegenerative diseases
Microglia have an increasingly well-recognised role in the pathogenesis of neurodegenerative diseases, thereby becoming attractive therapeutic targets. However, the development of microglia-targeted therapeutics for neurodegeneration has had limited success. This stems partly from the lack of clinically relevant microglia model systems. To circumvent this translational gap, patient-derived microglial cell models established using conventional 2D in vitro techniques have emerged. Though promising, these models lack the microenvironment and multicellular interactions of the brain needed to maintain microglial homeostasis. (S...
Source: Journal of Neuroimmunology - January 11, 2023 Category: Allergy & Immunology Authors: Carla Cun í-López, Romal Stewart, Anthony R. White, Hazel Quek Source Type: research
