Systemic administration of anti-CD20 indirectly reduces B cells in the inflamed meninges in a chronic model of central nervous system autoimmunity
Anti-CD20 B cell depleting therapies have demonstrated that B cells are important drivers of disease progress in Multiple Sclerosis, although the pathogenic mechanisms are not well understood. A population of B cells accumulates in the inflamed meninges in MS and also some chronic animal models of disease, typically adjacent to demyelinating lesions. The role of these meningeal B cells in disease is not known, nor is their susceptibility to anti-CD20 therapy. Here, we administered anti-CD20 to 2D2 IgHMOG spontaneous experimental autoimmune encephalomyelitis mice in the chronic phase of disease, after the establishment of m...
Source: Journal of Neuroimmunology - December 15, 2023 Category: Allergy & Immunology Authors: Yodit Tesfagiorgis, Eden Kemal, Heather C. Craig, Kate A. Parham, Steven M. Kerfoot Source Type: research
Clinical features and prognosis of Tibetan patients with neuromyelitis optica spectrum disorder are different from those of Han Chinese patients
We compared the prognosis of Tibetan and Han Chinese patients with neuromyelitis optica spectrum disorder (NMOSD). The Expanded Disability Status Scale (EDSS) score at each attack, response to immunosuppressive therapy, risk of first relapse, severe attack, visual disability, motor disability, and total risk of disability were compared between Tibetan and Han Chinese patients. Tibetan patients showed higher EDSS during acute attacks. Annualized relapse rate did not differ between groups. Risk of severe attack, visual disability, and total risk of disability were higher in Tibetan patients. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 13, 2023 Category: Allergy & Immunology Authors: Wenqin Luo, Xiaofei Wang, Lingyao Kong, Hongxi Chen, Ziyan Shi, Hongyu Zhou Source Type: research
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Source: Journal of Neuroimmunology - December 12, 2023 Category: Allergy & Immunology Source Type: research
Sjogren's syndrome meets Meige's syndrome
This report details a rare case where a patient simultaneously suffered from Sjogren's syndrome (SS) and Meige's syndrome (MS). SS, an autoimmune disorder, and MS, a rare neurological condition characterized by involuntary eyelid closure, presented in a 73-year-old male. The patient had been experiencing dry eye symptoms for the past 5 years, with the onset of eyelid spasms and tetanic eye closure occurring 3 years ago. Traditional treatments, including subthalamic nucleus deep brain stimulation, provided only temporary relief. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 9, 2023 Category: Allergy & Immunology Authors: Xuemei Li, Li Su, Yi Zhao Tags: Short Communication Source Type: research
Sleep deprivation aggravates lipopolysaccharide-induced anxiety, depression and cognitive impairment: The role of pro-inflammatory cytokines and synaptic plasticity-associated proteins
This study explored whether chronic sleep deprivation aggravates lipopolysaccharide-induced anxiety, depression, and cognitive impairment and assessed the underlying mechanisms. Lipopolysaccharide (250 μg/kg) was administered to adult mice for 9 days, accompanied with daily intermittent sleep deprivation from 12:00 to 18:00 by using an activity wheel. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 4, 2023 Category: Allergy & Immunology Authors: Yue-Ming Zhang, Ru-Meng Wei, Yi-Zhou Feng, Kai-Xuan Zhang, Yi-Jun Ge, Xiao-Yi Kong, Xue-Yan Li, Gui-Hai Chen Source Type: research
Cadmium exposure exacerbates immunological abnormalities in a BTBR T+ Itpr3tf/J autistic mouse model by upregulating inflammatory mediators in CD45R-expressing cells
Autism spectrum disorder (ASD) is a neurodevelopmental illness characterized by behavior, learning, communication, and social interaction abnormalities in various situations. Individuals with impairments usually exhibit restricted and repetitive actions. The actual cause of ASD is yet unknown. It is believed, however, that a mix of genetic and environmental factors may play a role in its development. Certain metals have been linked to the development of neurological diseases, and the prevalence of ASD has shown a positive association with industrialization. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - December 3, 2023 Category: Allergy & Immunology Authors: Thamer H. Albekairi, Mohammed M. Alanazi, Mushtaq A. Ansari, Ahmed Nadeem, Sabry M. Attia, Saleh A. Bakheet, Haneen A. Al-Mazroua, Abdullah A. Aldossari, Taghreed N. Almanaa, Mohammad Y. Alwetaid, Mohammed Alqinyah, Hajar O. Alnefaie, Sheikh F. Ahmad Source Type: research
Adult-onset neurodegeneration in XMEN disease
XMEN (X-linked immunodeficiency with magnesium defect, Epstein-Barr virus (EBV), and N-linked glycosylation defect) disease results from loss-of-function mutations in MAGT1, a protein that serves as a magnesium transporter and a subunit of the oligosaccharyltransferase (OST) complex. MAGT1 deficiency disrupts N-linked glycosylation, a critical regulator of immune function. XMEN results in recurrent EBV infections and a propensity for EBV-driven malignancies. Although XMEN is recognized as a systemic congenital disorder of glycosylation (CDG), its neurological involvement is rare and poorly characterized. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - November 23, 2023 Category: Allergy & Immunology Authors: Daniel Benavides, Anusha Ebrahim, Juan C. Ravell, Michael Lenardo, William A. Gahl, Camilo Toro Tags: Short Communication Source Type: research
Effect of the sEH inhibitor AUDA on arachidonic acid metabolism and NF- κB signaling of rats with postpartum depression-like behavior
To investigate whether sEH inhibitor AUDA can mitigate postpartum depression (PPD)-like symptoms in the rat model and regulate the AA/NF- κB pathway to suppress the inflammatory response in the prefrontal lobes of PPD rats. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - November 21, 2023 Category: Allergy & Immunology Authors: Liqin Duan, Linhong Song, Chao Qiu, Jingya Li Source Type: research
case of autoimmune GFAP astrocytopathy with eosinophils in the cerebrospinal fluid
Cerebrospinal fluid (CSF) eosinophilia is associated with a narrow differential, primarily including parasitic and fungal infections, neoplasm, and chemical meningitis. It has rarely been reported in neuroinflammatory conditions including as a finding of CSF cytology in two autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy cases. Here we describe a case of autoimmune GFAP astrocytopathy with classic clinical and radiographic features as well as presence of eosinophils in the CSF. This case highlights a potential association of eosinophils in the CSF with autoimmune GFAP astrocytopathy, which may suggest its ...
Source: Journal of Neuroimmunology - November 18, 2023 Category: Allergy & Immunology Authors: Mallory C. Lowe, Kelli M. Money, Elizabeth Matthews, Daniel M. Pastula, Amanda L. Piquet Tags: Short Communication Source Type: research
Progressive multifocal leukoencephalopathy secondary to idiopathic CD4 lymphocytopenia treated with pembrolizumab
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease due to a lytic infection of oligodendrocytes caused by John Cunningham polyoma virus (JCV) infection. Idiopathic CD4+ T-cell lymphocytopenia (ICL) is a very rare cause of PML. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - November 17, 2023 Category: Allergy & Immunology Authors: Kyriakoula Varmpompiti, Andrew J. Westwood, Aaron Ben-Joseph, Naomi Sibtain, Mohammad A.A. Ibrahim, Biba Stanton, Mark Zuckerman, Robert Hadden, Laura Mantoan Ritter Tags: Short Communication Source Type: research
Hydroxyurea interaction with α7 nicotinic acetylcholine receptor can underlie its therapeutic efficacy upon COVID-19
In this paper the authors provide evidence that hydroxyurea (hydroxycarbamide) interacts with α7 nicotinic acetylcholine receptor, exerts anti-inflammatory and pro-survival effect, prevents α7 nicotinic receptor interaction with angiotensin-converting enzyme-2 and stimulates IgM to IgG class switch upon immunization with SARS spike protein fragment 674–685. Hydroxyurea shifts immunoglobu lin glycosylation profile to anti-inflammatory phenotype and prevents the appearance of anti-idiotypic α7(179–190)-specific antibodies, as well as memory impairment. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - November 17, 2023 Category: Allergy & Immunology Authors: Olena Lykhmus, Olena Kalashnyk, Raymond Sullivan, Maryna Skok Source Type: research
Drug-drug interaction between paxlovid and tacrolimus in a patient with myasthenia gravis and SARS-CoV-2 infection
Patients with both myasthenia gravis (MG) and SARS-CoV-2 infection face treatment challenges due to potential drug interactions. One common immunosuppressant for MG, Tacrolimus, is primarily metabolized by the cytochrome P450. However, Paxlovid, an antiviral medication, inhibits cytochrome P450 activity, which can lead to increased Tacrolimus levels and potential toxicity when the two drugs are combined. In this case report, we present the case of a 39-year-old woman with early-onset MG who was initially treated with Tacrolimus. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - November 17, 2023 Category: Allergy & Immunology Authors: Ying Chen, Wenbin Wan, Xiaoying Yao, Yangtai Guan Tags: Short Communication Source Type: research
Systemic treatment with a selective TNFR2 agonist alters the central and peripheral immune responses and transiently improves functional outcome after experimental ischemic stroke
Ischemic stroke often leaves survivors with permanent disabilities and therapies aimed at limiting detrimental inflammation and improving functional outcome are still needed. Tumor necrosis factor (TNF) levels increase rapidly after ischemic stroke, and while signaling through TNF receptor 1 (TNFR1) is primarily detrimental, TNFR2 signaling mainly has protective functions. We therefore investigated how systemic stimulation of TNFR2 with the TNFR2 agonist NewSTAR2 affects ischemic stroke in mice. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - November 15, 2023 Category: Allergy & Immunology Authors: Estrid Thougaard, Pernille Vinther Nielsen, Amalie Forsberg, Victoria Phuong, Aitana Mart ínez Velasco, Agnieszka Wlodarczyk, Harald Wajant, Isabell Lang, Jens D. Mikkelsen, Bettina Hjelm Clausen, Roberta Brambilla, Kate Lykke Lambertsen Source Type: research
Voluntary wheel running from early adolescence reduces disease progression, and anxiety- and depression-related symptoms in an adult male mouse model of rheumatoid arthritis
This study aimed to assess whether voluntary wheel running from early adolescence can decrease clinical symptoms, anxiety- and depression-related behaviors in adult mice with rheumatoid arthritis. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - November 14, 2023 Category: Allergy & Immunology Authors: Sheida Payamipour, Maghsoud Peeri, Mohammad Ali Azarbayjani, Forouzan Fattahi Masrour Source Type: research
Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis
This study aims to investigate peripheral/blood concentrations of inflammatory molecules in HD. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - November 13, 2023 Category: Allergy & Immunology Authors: Alireza Soltani Khaboushan, Aysan Moeinafshar, Mohammad Hamed Ersi, Antonio L. Teixeira, Masoumeh Majidi Zolbin, Abdol-Mohammad Kajbafzadeh Tags: Review Article Source Type: research
