Sleep deprivation aggravates lipopolysaccharide-induced anxiety, depression and cognitive impairment: The role of pro-inflammatory cytokines and synaptic plasticity-associated proteins
This study explored whether chronic sleep deprivation aggravates lipopolysaccharide-induced anxiety, depression, and cognitive impairment and assessed the underlying mechanisms. Lipopolysaccharide (250 μg/kg) was administered to adult mice for 9 days, accompanied with daily intermittent sleep deprivation from 12:00 to 18:00 by using an activity wheel.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Yue-Ming Zhang, Ru-Meng Wei, Yi-Zhou Feng, Kai-Xuan Zhang, Yi-Jun Ge, Xiao-Yi Kong, Xue-Yan Li, Gui-Hai Chen Source Type: research
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