Free light chains as a reliable biomarker of intrathecal synthesis in the diagnosis of CNS inflammatory diseases
To address the diagnostic performances of cerebrospinal fluid (CSF) free light chains (FLC) measurements compared to oligoclonal bands (OCB) to support multiple sclerosis (MS) diagnosis. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 21, 2023 Category: Allergy & Immunology Authors: Laura Michetti, Francesca Maffina, Rudi Ravasio, Valeria Barcella, Marta Radaelli, Lorenzo Chiudinelli, Maria Sessa, Maria Grazia Alessio Source Type: research
Alemtuzumab treatment exemplifies discordant immune effects of blood and cerebrospinal fluid in multiple sclerosis
Immune responses in the central nervous system (CNS) are highly compartmentalized and cerebrospinal fluid (CSF) in particular often reflects CNS pathology better than peripheral blood. While CSF leukocytes are known to be distinct from blood, the immediate effects of peripheral leukocyte depletion on CSF leukocytes have not been studied in humans. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 11, 2023 Category: Allergy & Immunology Authors: Louisa M üller-Miny, Michael Heming, Tobias Lautwein, Tobias Ruck, I-Na Lu, Heinz Wiendl, Gerd Meyer Zu Hörste Source Type: research
Anti-Lactosylceramide antibody positive combined central peripheral demyelination emerging from long-standing juvenile-onset chronic inflammatory polyradiculoneuropathy; a report of two cases
Anti-Lactosylceramide (LacCer) antibodies are associated with neurological inflammation involving both the peripheral and central nervous system (PNS, CNS respectively), however, the documented number of cases is small. Uncertainty remains whether its positivity can identify a unique clinical entity. Here, we describe two anti-LacCer antibody positive cases, both with long histories (> 30 years) of teenage-diagnosed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). CNS lesions including the medulla oblongata were observed for the first time in adulthood. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 10, 2023 Category: Allergy & Immunology Authors: Naoki Takegami, Kaori Sakuishi, Nanaka Yamaguchi-Takegami, Shuhei Egashira, Shogo Komaki, Tatsuro Mutoh, Tatsushi Toda Tags: Short Communication Source Type: research
Risk factors of epilepsy secondary to viral encephalitis: A meta-analysis
To systematically evaluate the risk factors of post-encephalitis epilepsy (PEE). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 10, 2023 Category: Allergy & Immunology Authors: Qian Yang, Ben Wei Tags: Review Article Source Type: research
Neuro-Sj ögren: A clinical-radiological paradox affecting the central nervous system
We present the radiological follow-up of a patient with NSS who consulted for limb weakness and visual loss, and fourteen years late r developed sicca symptoms. She was diagnosed with a saliva gland biopsy, and started treatment with steroids, cyclophosphamide, and then rituximab, achieving a favourable clinical response and stabilization of lesions. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 7, 2023 Category: Allergy & Immunology Authors: Eduardo Villa, Alejandra Torres, Patricia Orellana, Jos é de Grazia, María Elena Villanueva, Carlos Guevara Tags: Short Communication Source Type: research
The role of multiple sclerosis therapies on the dynamic of human gut microbiota
Gut microbiota, the total microorganisms in our gastrointestinal tract, might have an implication in multiple sclerosis (MS), a demyelinating neurological disease. Our study included 50 MS patients and 21 healthy controls (HC). Twenty patients received a disease modifying therapy (DMT), interferon beta1a or teriflunomide, 19 DMT combined with homeopathy and 11 patients accepted only homeopathy. We collected in total 142 gut samples, two for each individual: at the study enrolment and eight weeks after treatment. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 7, 2023 Category: Allergy & Immunology Authors: Vitalie Vacaras, Dafin F. Muresanu, Anca-Dana Buzoianu, Cristina Nistor, Stefan Cristian Vesa, Andreea Cristina Paraschiv, Daniela Botos-Vacaras, Cristiana Vacaras, George Vithoulkas Source Type: research
Paediatric MOG-antibody disease presenting with intracranial hypertension and unilateral vision loss without radiological evidence of optic neuritis
We describe a unique case of seropositive MOGAD in an obese 13-year-old boy who presented with an isolated IH, bilateral optic disc swelling and sudden-onset complete vision loss in one eye without radiological evidence of optic nerve involvement. Treatment with intravenous methylprednisolone combined with an emergency shunt fully restored vision and resolved the optic disc swelling. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 5, 2023 Category: Allergy & Immunology Authors: Jack Jonathan Maran, Cynthia Sharpe, Stuart Carroll Tags: Short Communication Source Type: research
Anti-LGI1 encephalitis: A family affair
Here we describe the second ever-reported case of familial anti-leucine-rich glioma-inactivated protein 1 (LGI1) limbic encephalitis (LE). Two elderly Caucasian sisters presented with psychiatric symptoms and cognitive impairment, followed by faciobrachial dystonic seizures. Anti-LGI1 antibodies were detected in their serum. Considering they had been living in distant regions for decades, environmental factors could be ruled out. Human leukocyte antigen (HLA) genotyping revealed that both carried HLA-DRB1*07, found in 90% of anti-LGI1 encephalitis patients, HLA-DQA1*02:01 and HLA-DQB1*03:03, commonly associated with DRB1*0...
Source: Journal of Neuroimmunology - April 4, 2023 Category: Allergy & Immunology Authors: Gianfranco De Stefano, Patrizia Pulitano, Carlo Di Bonaventura, Luigi Zuliani, Alessandra Morano Tags: Short Communication Source Type: research
Cerebellar ataxia with anti-mGluR1 auto-antibody in a pediatric patient: A case report
This article reports the 4th case of mGluR1 related CA in a pediatric patient. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 3, 2023 Category: Allergy & Immunology Authors: Hongyan Wang, Bin Yi, Meng Wang, Yadan Wang, Juan Fu, Xindi Wang, Lei Cao Tags: Short Communication Source Type: research
Editorial Board
(Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - March 30, 2023 Category: Allergy & Immunology Source Type: research
Previous disease-modifying treatments influence T lymphocyte kinetics in people with multiple sclerosis switching to ocrelizumab
Recently, concern has been raised about the influence of the previous disease-modifying treatments (DMTs) on the clinical efficacy of ocrelizumab (OCR).We aimed to evaluate whether the previous DMT affects the lymphocyte subset kinetics in people with Multiple Sclerosis (MS) switching to OCR. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - March 25, 2023 Category: Allergy & Immunology Authors: Gianmarco Abbadessa, Giuseppina Miele, Paola Cavalla, Paola Valentino, Girolama Alessandra Marfia, Marco Vercellino, Antonio De Martino, Vittorio Simeon, Luigi Lavorgna, Simona Bonavita Source Type: research
Paraneoplastic Kelch-like protein 11 antibody-associated cerebellar and limbic encephalitis caused by metastatic “burned-out” seminoma – A scar(r)y phenomenon
The diagnosis of paraneoplastic neurologic syndromes is challenging when the primary tumor masquerades as scar tissue (i.e. “burned-out”). (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - March 22, 2023 Category: Allergy & Immunology Authors: Benedek Gyongyosi, Rita Magyar-Stang, Timea Takacs, Eszter Szekely, Zsolt Illes, Christine Nilsson, Tamas Gyorke, Peter Barsi, Daniel Juhasz, Balazs Banky, Daniel Bereczki, Jerome Honnorat, Bence Gunda Tags: Short Communication Source Type: research
CD3+CD56+ and CD3 −CD56+ lymphocytes in the cerebrospinal fluid of persons with HIV-1 subtypes B and C
The transactivator of transcription (Tat) is a HIV regulatory protein which promotes viral replication and chemotaxis. HIV-1 shows extensive genetic diversity, HIV-1 subtype C being the most dominant subtype in the world. Our hypothesis is the frequency of CSF CD3+CD56+ and CD3 −CD56dim is reduced in HIV-1C compared to HIV-1B due to the Tat C30S31 substitution in HIV-1C. 34 CSF and paired blood samples (PWH, n = 20; PWoH, n = 14) were studied. In PWH, the percentage of CD3+CD56+ was higher in CSF than in blood (p (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - March 17, 2023 Category: Allergy & Immunology Authors: Sergio M. de Almeida, Miriam Perlingeiro Beltrame, Bin Tang, Indianara Rotta, Julie Lilian P. Justus, Yara Schluga, Maria Tadeu da Rocha, Edna Martins, Antony Liao, Ian Abramson, Florin Vaida, Rachel Schrier, Ronald J. Ellis Source Type: research
The role of TREM1 in regulating microglial polarization in sevoflurane-induced perioperative neurocognitive disorders
This study aimed to evaluate the role of TREM1 in sevoflurane-induced PND. We applied AAV knockdown TREM1 in hippocampal microglia in aging mice. The mice were then subjected to neurobehavioral and biochemical testing after the intervention of sevoflurane. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - March 15, 2023 Category: Allergy & Immunology Authors: Chunchun Tang, Xue Zheng, Yuanping Zhong, Dongqin Chen, Yuhang Zhu, Sihui Wang, Liulin Xiong, Zhaoqiong Zhu Source Type: research
Autoimmune encephalitis misdiagnosis and mimics
The diagnosis of autoimmune encephalitis (AE) requires reasonable exclusion of other conditions. The aim of this study is to characterize mimickers and misdiagnoses of AE, thus we performed an independent PubMed search for mimickers of AEs or patients with alternative neurological disorders misdiagnosed as AE. Fifty-eight studies with 66 patients were included. Neoplastic (n = 17), infectious (n = 15), genetic (n = 13), neurodegenerative (n = 8), and other neurological (n = 8) or systemic autoimmune (n = 5) disorders were misdiagnosed as AE. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - March 15, 2023 Category: Allergy & Immunology Authors: Alessandro Dinoto, Pietro Zara, Sara Mariotto, Sergio Ferrari, Eoin P. Flanagan, Adrian Budhram, Daniela Orellana, Davide Turilli, Paolo Solla, Gregory S. Day, Elia Sechi, A. Sebastian Lopez-Chiriboga Tags: Review Article Source Type: research
