Exosome-transmitted ANGPTL1 suppresses angiogenesis in glioblastoma by inhibiting the VEGFA/VEGFR2/Akt/eNOS pathway

Glioblastoma (GBM) is a highly vascularized malignancy that relies on new vessel generation, and thus targeting angiogenesis has been a promising anti-GBM approach. ANGPTL1 is well-known for its anti-angiogenic property; nevertheless, its role in GBM is yet to be explored. Recently, the crucial role of exosomes (Exos) as intercellular communication mediators has gained prominence in GBM therapy. This work aimed to explore the role of exosomal ANGPTL1 in GBM angiogenesis and its mechanisms.

Source: Journal of Neuroimmunology - December 15, 2023 Category: Allergy & Immunology Authors: Dong Wang, Huichen Li, Tianxiang Zeng, Qiang Chen, Weilong Huang, Yujing Huang, Yuqing Liao, Qiuhua Jiang Source Type: research