YTHDF2 alleviates microglia activation via promoting circHIPK2 degradation

Microglial activation is a common cellular dysfunction in central nervous system inflammation, accompanied by abnormal expression of circular RNAs (circRNAs). YTHDF2, a N6-methyladenosine (m6A) reader, is known as a key element in RNA degradation. Here, lipolysaccharide induced microglia activation in mouse cortex and BV2 cells, accompanied by the decreased YTHDF2 and elevated circHIPK2. YTHDF2 overexpression or circHIPK2 knockdown in BV2 microglia inhibited the expressions of iNOS protein, IL-1 β mRNA and IL-6 mRNA.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research