Dysregulated autotaxin expression by T cells in multiple sclerosis
Multiple sclerosis (MS) is a demyelinating disease characterized by infiltration of autoreactive T cells into the central nervous system (CNS). In order to understand how activated, autoreactive T cells are able to cross the blood brain barrier, the unique molecular characteristics of pathogenic T cells need to be more thoroughly examined. In previous work, our laboratory found autotaxin (ATX) to be upregulated by activated autoreactive T cells in the mouse model of MS. ATX is a secreted glycoprotein that promotes T cell chemokinesis and transmigration through catalysis of lysophoshphatidic acid (LPA).
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Cora L. Petersen-Cherubini, Yue Liu, Joshua L. Deffenbaugh, Shawn P. Murphy, Matthew Xin, Christina N. Rau, Yuhong Yang, Amy E. Lovett-Racke Source Type: research