Increased production of inflammatory cytokines by circulating monocytes in mesial temporal lobe epilepsy: A possible role in drug resistance

We analyzed peripheral blood mononuclear cells (PBMCs) and serum inflammatory biomarkers in patients with mesial temporal lobe epilepsy (drug-resistant – DR, vs. drug-sensitive – DS). Patients with epilepsy showed higher levels of serum CCL2, CCL3, IL-8 and AOPP, and lower levels of FRAP and thiols compared to healthy controls (HC). Although none of the serum biomarkers distinguished DR from DS patients, when analysing intracellular cytokines a fter in vitro stimulation, DR patients presented higher percentages of IL-1β and IL-6 positive monocytes compared to DS patients and HC.

Source: Journal of Neuroimmunology - December 23, 2023 Category: Allergy & Immunology Authors: C. Milano, M. Montali, S. Barachini, I.S. Burzi, F. Pratesi, L. Petrozzi, L. Chico, R. Morganti, G. Gambino, L. Rossi, R. Ceravolo, G. Siciliano, P. Migliorini, I. Petrini, C. Pizzanelli Source Type: research