Journal of Biomedical Materials Research Part B: Applied Biomaterials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

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(Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 20, 2024 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research

Combination of in silico and cell culture strategies to predict biomaterial performance: Effects of sintering temperature on the biological properties of hydroxyapatite
In this study, differential gene expression analyses were performed using the gene set variat ion analysis (GSVA) algorithm from the transcriptomes respecting the thermal changes of HA, which were validated using exclusively in vitro strategies. Furthermore, in silico approaches elected biomarkers during cell behavior in response to different sintering temperatures of HA, and it was further validated using cell culture and qPCR technologies. Altogether, the combination of those strategies shows the capacity of sintered HA at 1250°C to present a better performance in organizing an adequate microenvironment favoring bone re...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 15, 2024 Category: Materials Science Authors: Gerson S. de Almeida, Marcel R. Ferreira, C élio C. Fernandes Jr, Carlos A. O. de Biagi Jr, Wilson Araújo Silva Jr, Elidiane C. Rangel, Paulo N. Lisboa‐Filho, Willian F. Zambuzzi Tags: RESEARCH ARTICLE Source Type: research

Functionalization of a zirconia surface by covalently immobilized fibronectin and its effects on resistance to thermal, acid, and mechanical exposure
In this study, we investigated the stability of the 3-aminopropyldiisopropylethoxysilane (APDS) layer on yttria-partially stabilized zirconia (Y-TZP) surfaces after mechanical, acid, and thermal treatment in order to simulate fluctuations within the oral cavity. To accomplish that, the viability of human gingival fibroblasts on APDS-modified surfaces after applied treatment strategies was assessed by live/dead staining. Moreover, the hydrolysis stability and enzymatic degradation resistance of crosslinked fibronectin to the APDS layer was examined by immunostaining and western blot. The results revealed that the applied mo...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 14, 2024 Category: Materials Science Authors: Alena L. Palkowitz, Taskin Tuna, Robert Kaufmann, Eva Miriam Buhl, Stefan Wolfart, Horst Fischer Tags: RESEARCH ARTICLE Source Type: research

Osseointegration of implant surfaces in metabolic syndrome and type ‐2 diabetes mellitus
AbstractThisin vivo study evaluated the bone healing response around endosteal implants with varying surface topography/chemistry in a preclinical, large transitional model induced with metabolic syndrome (MS) and type-2 diabetes mellitus (T2DM). Fifteen G öttingen minipigs were randomly distributed into two groups: (i) control (normal diet,n = 5) and (ii) O/MS (cafeteria diet for obesity induction,n = 10). Following obesity induction, five minipigs from the obese/metabolic syndrome (O/MS) group were further allocated, randomly, into the third experimental group: (iii) T2DM (cafeteria diet + streptozotocin). ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 14, 2024 Category: Materials Science Authors: Edmara T. P. Bergamo, Paula G. F. P. de Oliveira, Tiago M. B. Campos, Estevam A. Bonfante, Nick Tovar, Daniel Boczar, Vasudev Vivekanand Nayak, Paulo G. Coelho, Lukasz Witek Tags: RESEARCH ARTICLE Source Type: research

Combining PLGA microspheres loaded with Liver X receptor agonist GW3965 with a chitosan nerve conduit can promote the healing and regeneration of the wounded sciatic nerve
AbstractGlobally, peripheral nerve injury (PNI) is a common clinical issue. Successfully repairing severe PNIs has posed a major challenge for clinicians. GW3965 is a highly selective LXR agonist, and previous studies have demonstrated its positive protective effects in both central and peripheral nerve diseases. In this work, we examined the potential reparative effects of GW3965-loaded polylactic acid co-glycolic acid microspheres in conjunction with a chitosan nerve conduit for peripheral nerve damage. The experiment revealed that GW3965 promoted Schwann cell proliferation and neurotrophic factor release in vitro. In vi...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 14, 2024 Category: Materials Science Authors: Yuanwu Zhong, Shiqi Li, Yanzhen Chen, Yuan Tang, Xinmao Xiao, Tao Nie Tags: RESEARCH ARTICLE Source Type: research

In vivo behavior in rabbit radius bone defect of scaffolds based on nanocarbonate hydroxyapatite
In this study, we studied the bone-inducing capacity of nCHA-based scaffolds alone (SAG) and enriched with osteostatin (SAGO) or with bone marrow aspirate(SAGB) after implantation for 12  weeks in a 15-mm long critical defect performed in the radius of New Zealand rabbits. Bone formation obtained was compared with a group with the unfilled defect (CE), as control group, and other with the defect filed with iliac crest autograft (GS), as gold standard. X-ray follow-up was performed at 2, 4, 6 and 12 weeks and μCT and histological studies at 12 weeks. The radiological results showed a greater increment in bone formati...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 13, 2024 Category: Materials Science Authors: Lorena Garc ía‐Lamas, Juan Peña, Jesús Roman, Victoria Cabañas, Beatriz Bravo‐Giménez, Verónica Jiménez‐Díaz, Sandra Sánchez‐Salcedo, Javier Jiménez‐Holguín, Monica Abella, Manuel Desco, Daniel Lozano, David Cecilia‐Lópe Tags: RESEARCH ARTICLE Source Type: research

Degrees of macrophage ‐facilitated healing in aneurysm occlusion devices
AbstractInsufficient healing of aneurysms following treatment with vascular occlusion devices put patients at severe risk of fatal rupture. Therefore, promoting healing and not just occlusion is vital to enhance aneurysm healing. Following occlusion device implantation, healing is primarily orchestrated by macrophage immune cells, ending with fibroblasts depositing collagen to stabilize the aneurysm neck and dome, preventing rupture. Several modified occlusion devices are available currently on-market. Previous in vivo work demonstrated that modifications of occlusion devices with a shape memory polymer foam had enhanced a...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 12, 2024 Category: Materials Science Authors: Del A. Donehoo, Claudia A. Collier, Sabrina N. VandenHeuvel, Sanjana Roy, Spencer C. Solberg, Shreya A. Raghavan Tags: RESEARCH ARTICLE Source Type: research

Systematic enhancement of microbial decontamination efficiency in bone graft processing by means of high hydrostatic pressure using Escherichia coli as a model organism
This study aims to investigate the ability of high-pressure decontamination and to establish a treatment protocol that is able to successfully inactivate microorganisms with the final goal to sterilize bone specimens. UsingEscherichia coli (E. coli) as a model organism, HHP treatment parameters like temperature and duration, pressurization medium, and the number of treatment cycles were systematically adjusted to maximize the efficiency of inactivating logarithmic and stationary phase bacteria. Towards that we quantified colony-forming units (cfu) after treatment and investigated morphological changes via Field Emission Sc...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 12, 2024 Category: Materials Science Authors: Henrike Loeffler, Janine Waletzko ‐Hellwig, Ralf‐Joerg Fischer, Mirko Basen, Marcus Frank, Anika Jonitz‐Heincke, Rainer Bader, Annett Klinder Tags: RESEARCH ARTICLE Source Type: research

Characterization of residual debris on packaged hip arthroplasty stems demonstrates the dominance of less than 10  μm sized particulate: Updated USP788 guidelines for orthopedic implants
AbstractPast evaluation of particle contamination on packaged implants has typically been conducted using US Pharmacopeia (USP) 788, a 1970s pharmaceutical guideline created to evaluate contaminant particles in injectable fluids and syringes. Our objective was to reestablish relevant acceptance criteria for residual orthopedic and other implant debris, including smaller particles (i.e.,<10  μm in diameter). Packaged total hip arthroplasty (THA) titanium (Ti6Al4V)-alloy femoral stems were used (hydroxyapatite [HA]-coated and non-coated stems). Short-term ultrasonication and longer-term 24-hour soak/agitation methods w...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 11, 2024 Category: Materials Science Authors: Nadim J. Hallab, Salem R. Hallab, Anastasia Alexander, Robin Pourzal Tags: RESEARCH ARTICLE Source Type: research

Repair of a rat calvaria defect with injectable strontium (Sr) ‐doped polyphosphate dicalcium phosphate dehydrate (P‐DCPD) ceramic bone grafts
This study assessed the in vitro and in vivo performance of Sr-doped P-DCPD. In vitro P-DCPD and 10%Sr-P-DCPD were nontoxic and eluents from 10%Sr-P-DCPD significantly enhanced osteoblastic MC3T3 cell differentiation. A sustained, zero-order Sr release was observed from 10%Sr-P-DCPD for up to 70  days. When using this BGS in a rat calvaria defect model, both P-DCPD and 10% Sr-P-DCPD were found to be biocompatible and biodegradable. Histologic data from decalcified and undecalcified tissue showed that 10%Sr-P-DCPD had more extensive new bone formation compared with P-DCPD 12-weeks after su rgery and the 10%Sr-P-DCPD had m...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 10, 2024 Category: Materials Science Authors: David C. Markel, Paula R. Dietz, Bin Wu, Liang Chen, Therese Bou ‐Akl, Tong Shi, Weiping Ren Tags: RESEARCH ARTICLE Source Type: research

Proof of concept testing of a positive reference material for in vivo and in vitro sensitization testing of medical devices
In this study, polyurethane sheets containing 1  wt/wt % 2,4-dinitrochlorobenzene (DNCB-PU) were developed and evaluated as a positive reference material for skin sensitization tests. DNCB-PU sheet extracts prepared with sesame oil elicited positive sensitization responses for in vivo sensitization potential in the guinea pig maximization test and the local lymph node assay. Furthermore, DNCB-PU sheet extracts prepared with water and acetonitrile, 10% fetal bovine serum-containing medium, or sesame oil elicited positive sensitization responses as alternatives to animal testing based on the amino acid derivative reactivit...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 9, 2024 Category: Materials Science Authors: Yusuke Okamoto, Chie Fukui, Toshio Kobayashi, Hisako Morioka, Hideyuki Mizumachi, Yoriko Inomata, Atsushi Kaneki, Masayuki Okada, Yuji Haishima, Eiichi Yamamoto, Yusuke Nomura Tags: RESEARCH ARTICLE Source Type: research

Aloe vera ‐based biomaterial ink for 3D bioprinting of wound dressing constructs
This study emphasizes the development of a multifunctional biomaterial ink for wound healing constructs. The biomaterial ink benefits from Aloe vera's intrinsic biocompatible, biodegradable, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory attributes, thus alleviating the need for supplementary substances employed to combat infections and stimulate tissue regeneration. Moreover, this biomaterial ink seeks to address the scarcity of standardized printable materials possessing adequate biocompatibility and physicochemical properties, which hinder its widespread clinical adoption. The biomaterial ink was sy...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 9, 2024 Category: Materials Science Authors: M. Camila Ceballos ‐Santa, Alfonso Sierra, Iker Martinez Zalbidea, Emily Lazarus, Valeria Marin‐Montealegre, Srikanthan Ramesh, Patricia Iglesias, Karin Wuertz‐Kozak, Iris V. Rivero Tags: RESEARCH ARTICLE Source Type: research

Varying material thickness of silicone rubber for tunable nitric oxide release
In this study, SR is used in the first analysis of how a polymer's thickness affects the storage and uptake of an NO donor and subsequent release properties. Observed NO release trends show that a polymer's thickness results in tunable NO release. These results indicate how crucial a polymer's thickness is to optimize the NO release in an efficient and effective method. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 2, 2024 Category: Materials Science Authors: Patrick Maffe, Ryan Devine, Mark Garren, Hitesh Handa Tags: RESEARCH ARTICLE Source Type: research

Copper ‐doped magnesium phosphate nanopowders for critical size calvarial bone defect intervention
In this study, MgP and CuO-doped MgP were fabricated and characterized for their physicomechanical properties, particle size, morphology, surface area, antibacterial test, and in vitro bioactivity evaluation using the following techniques: X-rays diffraction, Fourier-transformer infrared, TEM, and Brunauer, Emmett and Teller (BET) surface area, X-rays photoelectron spectroscopy (XPS), and Scanning electron microscopy (SEM). Furthermore, these nanopowders were implanted in adult inbred male Wistar rats and studied after two periods (28 and 56  days). The results demonstrated that the obtained semiamorphous powders are in ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 1, 2024 Category: Materials Science Authors: Sara A. M. El ‐Sayed, Shaimaa ElShebiney, Hanan H. Beherei, Pradeep Kumar, Yahya E. Choonara, Mostafa Mabrouk Tags: RESEARCH ARTICLE Source Type: research

Enzyme ‐functionalized hydrogel film for extracorporeal uric acid reduction
AbstractEnzyme replacement therapy for hyperuricemia treatment has been proven effective for critical state hyperuricemia patients. Still, direct administration of recombinant uricase can induce several fatal side effects. To circumvent this drawback, hydrogel protein carriers can be used in platforms for extracorporeal treatment such as microscale-based devices. In this work, calcium alginate and poly-(vinyl alcohol) hydrogel films were studied for their urate oxidase immobilization and uric acid reduction, which could be implemented in microscale-based extracorporeal devices. A mathematical model was developed in conjunc...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 1, 2024 Category: Materials Science Authors: Jaturavit Pantakitcharoenkul, Jad Touma, Goran Jovanovic, Matthew Coblyn Tags: RESEARCH ARTICLE Source Type: research