Journal of Biomedical Materials Research Part B: Applied Biomaterials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Sustained release of alpha ‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition
This article presents silica nanoparticles for the sustained release of AMACR antibody-conjugated and free doxorubicin (DOX) for the inhibition of prostate cancer cell growth. Inorganic MCM-41 silica nanoparticles were synthesized, functionalized with phenylboronic acid groups (MCM-B), and capped with dextran (MCM-B-D). The nanoparticles were then characterized using Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, zeta potential analysis, nitrogen sorption, X-ray diffraction, and thermogravimetric analysis, before exploring their potential for drug loading and contro...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 1, 2022 Category: Materials Science Authors: Toyin Aina, Ali A. Salifu, Sonu Kizhakkepura, Yiporo Danyuo, John D. Obayemi, Josephine C. Oparah, Theresa C. Ezenwafor, Killian C. Onwudiwe, Chukwuemeka J. Ani, Suchi S. Biswas, Chinyerem Onyekanne, Olushola S. Odusanya, Jonathan Madukwe, Wi Tags: RESEARCH ARTICLE Source Type: research

Optimizing the composition of gelatin methacryloyl and hyaluronic acid methacryloyl hydrogels to maximize mechanical and transport properties using response surface methodology
AbstractHydrogel materials are promising candidates in cartilage tissue engineering as they provide a 3D porous environment for cell proliferation and the development of new cartilage tissue. Both the mechanical and transport properties of hydrogel scaffolds influence the ability of encapsulated cells to produce neocartilage. In photocrosslinkable hydrogels, both of these material properties can be tuned by changing the crosslinking density. However, the interdependent nature of the structural, physical and biological properties of photocrosslinkable hydrogels means that optimizing composition is typically a complicated pr...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 22, 2022 Category: Materials Science Authors: Alireza Talaei, Cathal D. O'Connell, Sepidar Sayyar, Malachy Maher, Zhilian Yue, Peter F. Choong, Gordon G. Wallace Tags: RESEARCH ARTICLE Source Type: research

Development of fibroblast/endothelial cell ‐seeded collagen scaffolds for in vitro prevascularization
This study aimed to culture human umbilical vein endothelial cells (HUVECs), alone or in co-culture with fibroblasts, on collagen scaffolds prepared by simple fabrication approaches for in vitro prevascularization. Different concentrations and ratios of HUVECs and fibroblasts seeded on collagen gel and sponge scaffolds under several culture conditions were examined. Cell viability, scaffolds morphology, and structure were analyzed. Collagen gel scaffolds showed good cell proliferation and viability, with higher proliferation rates for cells cultured in a 2:1 (fibroblasts: HUVECs) ratio and kept in endothelial cell growth m...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 20, 2022 Category: Materials Science Authors: Daniela S. Masson ‐Meyers, Fahimeh Tabatabaei, Lane Steinhaus, Jeffrey M. Toth, Lobat Tayebi Tags: RESEARCH ARTICLE Source Type: research

In vivo biocompatibility of SrO and MgO doped brushite cements
AbstractThe addition of dopants in biomaterials has emerged as a critical regulator of bone formation and regeneration due to their imminent role in the biological process. The present work evaluated the role of strontium (Sr) and magnesium (Mg) dopants in brushite cement (BrC) on in vivo bone healing performance in a rabbit model. Pure, 1  wt% SrO (Sr-BrC), 1 wt% MgO (Mg-BrC), and a binary composition of 1.0 wt% SrO + 1.0 wt% MgO (Sr + Mg-BrC) BrCs were implanted into critical-sized tibial defects in rabbits for up to 4 months. The in vivo bone healing of three doped and pure BrC samples was examined and comp...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 19, 2022 Category: Materials Science Authors: Samit K. Nandi, Mangal Roy, Amit Bandyopadhyay, Susmita Bose Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 17, 2022 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research

In vitro and in vivo evaluation of surface functionalization of titanium with H2O2 hydrothermal treatment and FGF ‐2
AbstractThe goals of the study were to investigate the effects on bone bioactivity of a titanium dioxide layer formed by hydrothermal oxidation of a titanium surface with hydrogen peroxide (H2O2) and loading with fibroblast growth factor-2 (FGF-2) in vitro and in vivo. Ti-6Al-4V discs were hydrothermally oxidized with H2O2 and then loaded with FGF-2. After cytotoxicity testing, Ti-6Al-4V mini-implants were subjected to the same treatment, and their osteogenic potential was evaluated histologically in a rat model. H2O2 hydrothermal oxidation resulted in a dense porous network structure and hydrophilic changes, which improve...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 17, 2022 Category: Materials Science Authors: Yuya Yoneyama, Tomonori Matsuno, Masako Fujioka ‐Kobayashi, Takafumi Satomi Tags: RESEARCH ARTICLE Source Type: research

A comprehensive review on hydrogel materials in urology: Problems, methods, and new opportunities
AbstractHydrogel materials provide an extremely promising group of materials that can find an increasingly wide range of use in treating urinary system conditions due to their unique properties. The present review describes achievements to date in terms of the use and development prospects of hydrogel materials applications in the treatment and reconstruction of the urinary system organs, which among others include: hydrogel systems of intravesical drug delivery, ureteral stents design, treatment of vesicoureteral reflux, urinary bladder and urethral defects reconstruction, design of modern urinary catheters and also solut...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 14, 2022 Category: Materials Science Authors: Adrianna Wierzbicka, Marek Krakos, Piotr Wilczek, Dorota Bociaga Tags: REVIEW ARTICLE Source Type: research

Cerium oxide nanoparticles exert antitumor effects and enhance paclitaxel toxicity and activity against breast cancer cells
AbstractCerium oxide nanoparticles (CeONPs) displayed cytotoxic properties against some cancer cells. However, there is very limited data about the possible antitumoral potential of them in breast cancer cells when used alone and/or together with a chemotherapeutic drug. We investigated the effects of CeONPs alone or in combination with paclitaxel (PAC) on healthy or carcinoma breast cells. After human breast cancer cells (MCF-7) treated with CeONPs alone or together with PAC for 24, 48, and 72  h, the effects of CeONPs on cell viability, apoptosis, migration, and adhesion were investigated. All cell viability and IC50 v...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 12, 2022 Category: Materials Science Authors: Z ülal Atlı Şekeroğlu, Vedat Şekeroğlu, Birsen Aydın, Seval Kontaş Yedier Tags: RESEARCH ARTICLE Source Type: research

Comparison of temporomandibular joint disc, meniscus, and intervertebral disc in fundamental characteristics and tissue engineering
AbstractThe temporomandibular joint (TMJ) disc, meniscus and intervertebral disc (IVD) are three fibrocartilage discs, which play critical roles in our daily life. Their degeneration contributes to diseases such as TMJ disorders, osteoarthritis and degenerative disc disease, affecting patients' quality of life and causing substantial morbidity and mortality. Interestingly, similar in some aspects of fundamental characteristics, they exhibit differences in other aspects such as biomechanical properties. Highlighting these similarities and differences can not only benefit a comprehensive understanding of them and their patho...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 12, 2022 Category: Materials Science Authors: Yilin She, Shiyi Tang, Zilin Zhu, Yixin Sun, Wanyu Deng, Sicheng Wang, Nan Jiang Tags: REVIEW ARTICLE Source Type: research

Mechanical alterations of electrospun poly( ϵ‐caprolactone) in response to convective thermobonding
AbstractVascular graft failure has persisted as a major clinical problem. Mechanical, structural, and transport properties of vascular grafts are critical factors that substantially affect their function and thus the outcome of implantation. The manufacturing method, post-processing technique, and material of choice have a significant impact on these properties. The goal of this work is to use thermal treatment to modulate the transport properties of PCL-based vascular engineered constructs. To this end, we electrospun PCL tubular constructs and thermally bonded the electrospun fibers in a convective oven at various temper...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 12, 2022 Category: Materials Science Authors: Ali Behrangzade, Hannah R. Keeney, Katarina M. Martinet, William R. Wagner, Jonathan P. Vande Geest Tags: RESEARCH ARTICLE Source Type: research

Biomimetic engineered approaches for neural tissue engineering: Spinal cord injury
AbstractThe healing process for spinal cord injuries is complex and presents many challenges. Current advances in nerve regeneration are based on promising tissue engineering techniques, However, the chances of success depend on better mimicking the extracellular matrix (ECM) of neural tissue and better supporting neurons in a three-dimensional environment. The ECM provides excellent biological conditions, including desirable morphological features, electrical conductivity, and chemical compositions for neuron attachment, proliferation and function. This review outlines the rationale for developing a construct for neuron r...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 11, 2022 Category: Materials Science Authors: Soheila Pourkhodadad, Hessam Hosseinkazemi, Shahin Bonakdar, Houra Nekounam Tags: REVIEW ARTICLE Source Type: research

A comparative in vitro and in vivo study of porcine ‐ and bovine‐derived non‐cross‐linked collagen membranes
AbstractThe porcine-derived non-cross-linked collagen membrane Bio-gide ® (BG) and the bovine-derived non-cross-linked collagen membrane Heal-all® (HA) were compared to better understand their in vitro biophysical characteristics and in vivo degradation patterns as a reference for clinical applications. It was showed that the porosity, specific surface area, pore volu me and pore diameter of BG were larger than those of HA (64.5 ± 5.2% vs. 48.6 ± 6.1%; 18.6 ± 2.8 m2/g vs. 2.3  ± 0.6 m2/g; 0.114  ± 0.002 cm3/g vs. 0.003  ± 0.001 cm3/g; 24.4  ± 3.5 nm vs. 7.3 ± 1.7 nm, respec...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 10, 2022 Category: Materials Science Authors: Mengdi Zhu, Beibei Duan, Kegui Hou, Lisha Mao, Xuejiu Wang Tags: RESEARCH ARTICLE Source Type: research

A three ‐dimensional model to describe complete human corneal oxygenation during contact lens wear
A full 3D axisymmetric and time-dependent model of the cornea-lens system has been numerically solved to determine the oxygen flux and consumption in each part of the cornea. We apply our model to different lenses currently usted on the market, showing the importance of detailed geometry in the modelling of these systems. AbstractWe perform a novel 3D study to quantify the corneal oxygen consumption and diffusion in each part of the cornea with different contact lens materials. The oxygen profile is calculated as a function of oxygen tension at the cornea-tear interface and the oxygen transmissibility of the lens, with val...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 10, 2022 Category: Materials Science Authors: Marcel Aguilella ‐Arzo, Vicente Compañ Tags: RESEARCH ARTICLE Source Type: research

Subsidence of a partially porous titanium lumbar cage produced by electron beam melting technology
AbstractThe lumbar intervertebral devices are widely used in the surgical treatment of lumbar diseases. The subsidence represents a serious clinical issue during the healing process, mainly when the interfaces between the implant and the vertebral bodies are not well designed. The aim of this study is the evaluation of subsidence risk for two different devices. The devices have the same shape, but one of them includes a filling micro lattice structure. The effect of the micro lattice structure on the subsidence behavior of the implant was evaluated by means of both experimental tests and finite element analyses. Compressiv...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 8, 2022 Category: Materials Science Authors: Fabio Distefano, Gabriella Epasto, Eugenio Guglielmino, Aurora Amata, Rosalia Mineo Tags: RESEARCH ARTICLE Source Type: research

Bioactive fluorcanasite reinforced magnesium alloy ‐based porous bio‐nanocomposite scaffolds with tunable mechanical properties
Magnesium alloy-based biomimetic bone scaffolds; fabrication, microstructural and mechanical properties. AbstractMagnesium (Mg) alloy-based porous bio-nanocomposite bone scaffolds were developed by powder metallurgy route. Selective alloying elements such as calcium (Ca), zinc (Zn) and strontium (Sr) were incorporated to tune the mechanical integrity while, bioactive fluorcanasite nano-particulates were introduced within the alloy system to enhance the bone tissue regeneration. Green compacts containing carbamide were fabricated and sintered using two-stage heat treatment process to achieve the targeted porosities. The mic...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 8, 2022 Category: Materials Science Authors: Adithya Garimella, Ramya M, Subrata Bandhu Ghosh, Sanchita Bandyopadhyay ‐Ghosh, Ashish Kumar Agrawal Tags: RESEARCH ARTICLE Source Type: research